Sce PUS1

Catalog #M0526

  • Sce PUS1 isomerizes uridine to pseudouridine in predominantly single-stranded RNA in vitro
  • Sce PUS1 is a stand-alone enzyme and does not require an RNA guide or co-factor to modify RNA
  • Sequence-specific pseudouridine modification by Sce PUS1 is an alternative to randomly incorporated modified nucleosides by RNA polymerases

This is an Enzyme for Innovation (EFI). EFI is a project initiated by NEB to provide unique enzymes to the scientific community in the hopes of enabling the discovery of new and innovative applications. These enzymes have interesting properties and unique specificities.

  • Product Information
    Sce Pseudouridine Synthase I (Sce PUS1) converts Uridine to Pseudouridine in single-stranded RNA, with a preference for Uridines in single-stranded RNA regions over Uridines in double-stranded RNA. The optimal substrate is an unstructured RNA that is 15 nt long or longer.

    Reagents Supplied

    The following reagents are supplied with this product:

    Store at (°C) Concentration
    NEBuffer™ 1.1 -20 10 X
    Product Categories:
    RNA Modification Products,
    RNA Reagents Products,
    RNA Synthesis Products
    RNA Modification,
    RNA Analysis,
    In vitro Synthesis (IVT)
  • Quality, Safety & Legal
    • Quality Control Assays
    • Safety Data Sheets
    • Legal and Disclaimers

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