RNA Synthesis and Modification IVT Product Portfolio

RNA Synthesis and Modification

RNA plays a multitude of cellular roles in all kingdoms of life and is a promising area of research in biotechnology and therapeutic development. RNA is an essential carrier of genetic information that can catalyze chemical reactions and influence gene expression. Our understanding of RNAs as regulatory molecules in the cell has dramatically changed over the last decade. Many new classes of small and large non-coding RNAs with largely unexplored functions have been recently reported, ushering in a renaissance of RNA-focused research in biology. NEB's RNA reagents can be ordered in bulk, GMP-grade*, or customized formats for advanced research and development projects, please contact our Customized Solutions team for more information.

NEB provides in vitro transcription (IVT) reagents from bench-scale to commercial-scale

NEB offers a range of products for RNA research, including reagents for synthesis, extraction, purification, cleanup, analysis, modification, and detection of RNA molecules. These products are available from bench-scale to commercial-scale to serve both academic and industrial needs. Further, we provide these products at quality levels that support vaccine and diagnostic manufacturing. Experience improved performance and increased yields, enabled by our expertise in enzymology.

 

GMP= available in GMP-grade

* "GMP-grade" is a branding term NEB uses to describe products manufactured or finished at NEB’s Rowley facility. The Rowley facility was designed to manufacture products under more rigorous infrastructure and process controls to achieve more stringent product specifications and customer requirements. Products manufactured at NEB’s Rowley facility are manufactured in compliance with ISO 9001 and ISO 13485 quality management system standards.. However, at this time, NEB does not manufacture or sell products known as Active Pharmaceutical Ingredients (APIs), nor does NEB manufacture its products in compliance with all of the Current Good Manufacturing Practice regulations.


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RNA Synthesis and Modification

RNA Capping

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3´-O-Me-m7G(5')ppp(5')G RNA Cap Structure Analog

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Faustovirus Capping Enzyme

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G(5')ppp(5')A RNA Cap Structure Analog

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G(5')ppp(5')G RNA Cap Structure Analog

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HiScribe® SP6 RNA Synthesis Kit

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HiScribe® T7 ARCA mRNA Kit

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HiScribe® T7 ARCA mRNA Kit (with tailing)

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HiScribe® T7 High Yield RNA Synthesis Kit

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HiScribe® T7 mRNA Kit with CleanCap® Reagent AG

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m7G(5')ppp(5')A RNA Cap Structure Analog

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mRNA Cap 2´-O-Methyltransferase

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Vaccinia Capping System

RNA Extraction and Purification

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Magnetic mRNA Isolation Kit

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Monarch® Buffer BX

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Monarch® Buffer WX

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Monarch® Collection Tubes II

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Monarch® DNA/RNA Protection Reagent

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Monarch® gDNA Removal Columns

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Monarch® gDNA Wash Buffer

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Monarch® Pestle Set

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Monarch® RNA Lysis Buffer

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Monarch® RNA Priming Buffer

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Monarch® RNA Purification Columns

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Monarch® RNA Wash Buffer

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Monarch® Spin Columns S1A and Tubes

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Monarch® Spin Columns S2A and Tubes

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Monarch® Spin Columns S2B and Tubes

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Monarch® Spin RNA Cleanup Kit (10 μg)

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Monarch® Spin RNA Cleanup Kit (50 μg)

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Monarch® Spin RNA Cleanup Kit (500 μg)

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Monarch® Spin RNA Isolation Kit (Mini)

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Monarch® Total RNA Miniprep Enzyme Pack

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Monarch® Total RNA Miniprep Kit

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Nuclease-free Water

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Oligo d(T)25 Magnetic Beads

RNA Ligation

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5´ DNA Adenylation Kit

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RtcB Ligase

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SplintR® Ligase

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T4 RNA Ligase 1 (ssRNA Ligase)

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T4 RNA Ligase 1 (ssRNA Ligase), High Concentration

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T4 RNA Ligase 2 (dsRNA Ligase)

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T4 RNA Ligase 2, truncated

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T4 RNA Ligase 2, truncated K227Q

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T4 RNA Ligase 2, truncated KQ

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T4 RNA Ligase Reaction Buffer

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Thermostable 5´ App DNA/RNA Ligase

RNA Markers and Ladders

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dsRNA Ladder

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Low Range ssRNA Ladder

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microRNA Marker

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RNA Loading Dye, (2X)

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ssRNA Ladder

RNA Modification

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3´-Biotin-GTP

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3´-Desthiobiotin-GTP

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5´ Deadenylase

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5-Methoxy-Uridine-5´-Triphosphate (5-Methoxy-UTP)

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5-Methyl-Cytidine-5´-Triphosphate (5-Methyl-CTP)

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Antarctic Phosphatase

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Apyrase

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E. coli Poly(A) Polymerase

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E. coli RNA Polymerase, Holoenzyme

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EpiMark® N6-Methyladenosine Enrichment Kit

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FTO RNA Demethylase

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Hydrophilic Streptavidin Magnetic Beads

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Micrococcal Nuclease

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mRNA Decapping Enzyme

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Mung Bean Nuclease

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N1-Methyl-Pseudouridine-5´-Triphosphate (N1-Methyl-Pseudo-UTP)

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Nucleoside Digestion Mix

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NudC Pyrophosphatase

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Pseudouridine-5´-Triphosphate (Pseudo-UTP)

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Pyrophosphatase, Inorganic (E. coli)

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Pyrophosphatase, Inorganic (yeast)

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Quick CIP

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RNA 5' Pyrophosphohydrolase (RppH)

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RNase 4 Digestion and 3´ End Repair Mix

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RNase R

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Sce PUS1

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T4 Polynucleotide Kinase (3' phosphatase minus)

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Thermostable Inorganic Pyrophosphatase

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XRN-1

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yDcpS

RNA Synthesis In vitro Transcription (IVT)

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3´-Biotin-GTP

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3´-Desthiobiotin-GTP

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5-Methoxy-Uridine-5´-Triphosphate (5-Methoxy-UTP)

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5-Methyl-Cytidine-5´-Triphosphate (5-Methyl-CTP)

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DNase I (RNase-free)

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DNase I-XT

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E. coli Poly(A) Polymerase

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E. coli RNA Polymerase, Core Enzyme

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E. coli RNA Polymerase, Holoenzyme

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HiScribe® SP6 RNA Synthesis Kit

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HiScribe® T7 ARCA mRNA Kit

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HiScribe® T7 ARCA mRNA Kit (with tailing)

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HiScribe® T7 High Yield RNA Synthesis Kit

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HiScribe® T7 mRNA Kit with CleanCap® Reagent AG

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HiScribe® T7 Quick High Yield RNA Synthesis Kit

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Hi-T7® RNA Polymerase

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Hi-T7® RNA Polymerase (High Concentration)

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m7G(5')ppp(5')G RNA Cap Structure Analog

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N1-Methyl-Pseudouridine-5´-Triphosphate (N1-Methyl-Pseudo-UTP)

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Poly(U) Polymerase

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Pseudouridine-5´-Triphosphate (Pseudo-UTP)

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Pyrophosphatase, Inorganic (E. coli)

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Pyrophosphatase, Inorganic (yeast)

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Ribonucleotide Solution Set

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Ribonucleotide Solution Mix

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RNase Inhibitor, Human Placenta

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RNase Inhibitor, Murine

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SP6 RNA Polymerase

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T3 RNA Polymerase

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T7 RNA Polymerase

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T7 RNA Polymerase (High Concentration)

RNase Inhibitors

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Ribonucleoside Vanadyl Complex

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RNase Inhibitor, Human Placenta

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RNase Inhibitor, Murine

RNases

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Exonuclease T

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Monarch® RNase A

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RNase 4

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RNase 4 Digestion and 3´ End Repair Mix

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RNase H

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RNase HII

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RNase If

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RNase R

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ShortCut® RNase III

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Thermostable RNase H

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XRN-1

RNA Capping
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3´-O-Me-m7G(5')ppp(5')G RNA Cap Structure Analog

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Faustovirus Capping Enzyme

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G(5')ppp(5')A RNA Cap Structure Analog

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G(5')ppp(5')G RNA Cap Structure Analog

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HiScribe® SP6 RNA Synthesis Kit

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HiScribe® T7 ARCA mRNA Kit

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HiScribe® T7 ARCA mRNA Kit (with tailing)

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HiScribe® T7 High Yield RNA Synthesis Kit

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HiScribe® T7 mRNA Kit with CleanCap® Reagent AG

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m7G(5')ppp(5')A RNA Cap Structure Analog

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mRNA Cap 2´-O-Methyltransferase

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Vaccinia Capping System

RNA Extraction and Purification
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Magnetic mRNA Isolation Kit

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Monarch® Buffer BX

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Monarch® Buffer WX

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Monarch® Collection Tubes II

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Monarch® DNA/RNA Protection Reagent

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Monarch® gDNA Removal Columns

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Monarch® gDNA Wash Buffer

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Monarch® Pestle Set

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Monarch® RNA Lysis Buffer

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Monarch® RNA Priming Buffer

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Monarch® RNA Purification Columns

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Monarch® RNA Wash Buffer

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Monarch® Spin Columns S1A and Tubes

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Monarch® Spin Columns S2A and Tubes

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Monarch® Spin Columns S2B and Tubes

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Monarch® Spin RNA Cleanup Kit (10 μg)

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Monarch® Spin RNA Cleanup Kit (50 μg)

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Monarch® Spin RNA Cleanup Kit (500 μg)

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Monarch® Spin RNA Isolation Kit (Mini)

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Monarch® Total RNA Miniprep Enzyme Pack

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Monarch® Total RNA Miniprep Kit

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Nuclease-free Water

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Oligo d(T)25 Magnetic Beads

RNA Ligation
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5´ DNA Adenylation Kit

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RtcB Ligase

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SplintR® Ligase

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T4 RNA Ligase 1 (ssRNA Ligase)

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T4 RNA Ligase 1 (ssRNA Ligase), High Concentration

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T4 RNA Ligase 2 (dsRNA Ligase)

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T4 RNA Ligase 2, truncated

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T4 RNA Ligase 2, truncated K227Q

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T4 RNA Ligase 2, truncated KQ

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T4 RNA Ligase Reaction Buffer

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Thermostable 5´ App DNA/RNA Ligase

RNA Markers and Ladders
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dsRNA Ladder

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Low Range ssRNA Ladder

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microRNA Marker

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RNA Loading Dye, (2X)

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ssRNA Ladder

RNA Modification
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3´-Biotin-GTP

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3´-Desthiobiotin-GTP

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5´ Deadenylase

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5-Methoxy-Uridine-5´-Triphosphate (5-Methoxy-UTP)

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5-Methyl-Cytidine-5´-Triphosphate (5-Methyl-CTP)

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Antarctic Phosphatase

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Apyrase

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E. coli Poly(A) Polymerase

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E. coli RNA Polymerase, Holoenzyme

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EpiMark® N6-Methyladenosine Enrichment Kit

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FTO RNA Demethylase

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Hydrophilic Streptavidin Magnetic Beads

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Micrococcal Nuclease

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mRNA Decapping Enzyme

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Mung Bean Nuclease

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N1-Methyl-Pseudouridine-5´-Triphosphate (N1-Methyl-Pseudo-UTP)

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Nucleoside Digestion Mix

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NudC Pyrophosphatase

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Pseudouridine-5´-Triphosphate (Pseudo-UTP)

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Pyrophosphatase, Inorganic (E. coli)

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Pyrophosphatase, Inorganic (yeast)

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Quick CIP

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RNA 5' Pyrophosphohydrolase (RppH)

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RNase 4 Digestion and 3´ End Repair Mix

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RNase R

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Sce PUS1

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T4 Polynucleotide Kinase (3' phosphatase minus)

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Thermostable Inorganic Pyrophosphatase

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XRN-1

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yDcpS

RNA Synthesis In vitro Transcription (IVT)
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3´-Biotin-GTP

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3´-Desthiobiotin-GTP

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5-Methoxy-Uridine-5´-Triphosphate (5-Methoxy-UTP)

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5-Methyl-Cytidine-5´-Triphosphate (5-Methyl-CTP)

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DNase I (RNase-free)

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DNase I-XT

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E. coli Poly(A) Polymerase

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E. coli RNA Polymerase, Core Enzyme

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E. coli RNA Polymerase, Holoenzyme

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HiScribe® SP6 RNA Synthesis Kit

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HiScribe® T7 ARCA mRNA Kit

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HiScribe® T7 ARCA mRNA Kit (with tailing)

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HiScribe® T7 High Yield RNA Synthesis Kit

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HiScribe® T7 mRNA Kit with CleanCap® Reagent AG

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HiScribe® T7 Quick High Yield RNA Synthesis Kit

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Hi-T7® RNA Polymerase

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Hi-T7® RNA Polymerase (High Concentration)

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m7G(5')ppp(5')G RNA Cap Structure Analog

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N1-Methyl-Pseudouridine-5´-Triphosphate (N1-Methyl-Pseudo-UTP)

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Poly(U) Polymerase

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Pseudouridine-5´-Triphosphate (Pseudo-UTP)

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Pyrophosphatase, Inorganic (E. coli)

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Pyrophosphatase, Inorganic (yeast)

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Ribonucleotide Solution Set

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Ribonucleotide Solution Mix

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RNase Inhibitor, Human Placenta

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RNase Inhibitor, Murine

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SP6 RNA Polymerase

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T3 RNA Polymerase

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T7 RNA Polymerase

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T7 RNA Polymerase (High Concentration)

RNase Inhibitors
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Ribonucleoside Vanadyl Complex

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RNase Inhibitor, Human Placenta

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RNase Inhibitor, Murine

RNases
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Exonuclease T

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Monarch® RNase A

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RNase 4

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RNase 4 Digestion and 3´ End Repair Mix

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RNase H

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RNase HII

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RNase If

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RNase R

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ShortCut® RNase III

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Thermostable RNase H

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XRN-1


Choose Type:

RNA Synthesis and Modification includes these subcategories:
RNA Capping
RNA Extraction and Purification
RNA Ligation
RNA Markers and Ladders
RNA Modification
RNA Synthesis In vitro Transcription (IVT)
RNase Inhibitors
RNases
Application Notes for RNA Synthesis and Modification
Legal Information

Products and content are covered by one or more patents, trademarks and/or copyrights owned or controlled by New England Biolabs, Inc (NEB). The use of trademark symbols does not necessarily indicate that the name is trademarked in the country where it is being read; it indicates where the content was originally developed. All other trademarks are the property of their respective owners. The use of this product may require the buyer to obtain additional third-party intellectual property rights for certain applications. For more information, please email busdev@neb.com.

This product is intended for research purposes only. This product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.

 


Get started with these RNA-related references:

RNA Synthesis Brochure
Learn more about NEB's products for synthesis of RNA, which range from template generation to poly(A) tailing.

RNA Technical Guide
Find in-depth information on tools designed to streamline your RNA workflows, including RNA extraction & purification, qPCR & RT-qPCR, RNAseq, RNA synthesis and sgRNA synthesis

Interactive Timeline of mRNA Discoveries
Get caught up on key mRNA discoveries with our interactive timeline, featuring a selection of publications and resources from the last seven decades.

RNA Metro Map Poster
Download our RNA poster to learn more about the various RNA structures and recent applications.


“RNase-free” Zone Sticker Pack

RNA_Sticker_Mockup_300w

Sign up for the RNA Newsletter and receive a free "RNase-free Zone" sticker pack.

Sign up

Faced with challenges in mRNA manufacturing & scale-up?

RNA eBook cover

Download eBook

Get started with these RNA-related references:

RNA Synthesis Brochure
Learn more about NEB's products for synthesis of RNA, which range from template generation to poly(A) tailing.

RNA Technical Guide
Find in-depth information on tools designed to streamline your RNA workflows, including RNA extraction & purification, qPCR & RT-qPCR, RNAseq, RNA synthesis and sgRNA synthesis

Interactive Timeline of mRNA Discoveries
Get caught up on key mRNA discoveries with our interactive timeline, featuring a selection of publications and resources from the last seven decades.

RNA Metro Map Poster
Download our RNA poster to learn more about the various RNA structures and recent applications.


“RNase-free” Zone Sticker Pack

RNA_Sticker_Mockup_300w

Sign up for the RNA Newsletter and receive a free "RNase-free Zone" sticker pack.

Sign up

Faced with challenges in mRNA manufacturing & scale-up?

RNA eBook cover

Download eBook