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T4 PDG (pyrimidine dimer glycosylase) has both DNA glycosylase and APlyase activity. The 16 kd protein recognizes cis-syn-cyclobutane pyrimidine dimers caused by UV irradiation. The enzyme cleaves the glycosyl bond of the 5´ end of the pyrimidine dimer and the endonucleolytic activity cleaves the phosphodiester bond at the AP site. Product Source
Purified from an E. coli strain carrying a plasmid encoding T4 denV gene.- This product is related to the following categories:
- DNA Repair Enzymes and Structure-specific Endonucleases Products
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