TelN Protelomerase
Gray property icon for NEBU Gray property icon for cloned at NEB recombinant 30 75 Heat

This product was discontinued and replaced by EnClose TelN Protelomerase (NEB #M0768).

GMP-grade reagent also available. Learn more.

  • Catalog # M0651 was discontinued on June 15, 2026

Mechanism of TelN Protelomerase, which forms covalently closed ends

  • TelN Protelomerase is a telomere resolvase
  • Cuts dsDNA at a TelN recognition sequence (56 bp) 
  • Leaves covalently closed ends through hairpin formation via tyrosine-mediated cleavage
  • This is an Enzyme for Innovation (EFI) graduate.  EFI is a project initiated by NEB to provide unique enzymes to the scientific community in the hopes of enabling the discovery of new and innovative applications.

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