Supporting biotherapeutic discovery, manufacturing & analysis
Product support for scientists developing, manufacturing & analyzing biotherapeutics
Innovative biotherapeutics, including gene therapies, protein/antibody treatments, and nucleic acid therapies, are revolutionizing disease treatment. At New England Biolabs, we have over five decades of experience pushing the limits of molecular biology to create advanced enzymes and reagents to support the discovery of transformative biotherapeutic therapies. Our extensive range of high-quality reagents are designed to meet the needs of scientists working to discover, manufacture, and analyze these cutting-edge therapies. With a commitment to innovation and collaboration, we work with scientists like you to push the boundaries of biotherapeutics, ultimately bringing life changing therapies to people across the globe.
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Biotherapeutic |
Biotherapeutic |
Biotherapeutic discovery/development
Molecular biology tools and techniques are at the heart of the discovery and pre-clinical development of groundbreaking biotherapeutics, including gene, protein/antibody, and nucleic acid therapies. Techniques such as CRISPR gene editing, recombinant DNA technology, and next generation sequencing are indispensable for identifying therapeutic targets, engineering therapeutic proteins and antibodies, and developing nucleic acid therapies. Our growing and diverse portfolio of products is designed to provide the tools needed by researchers investigating new biotherapeutics.
| Application | Product Name | |
|---|---|---|
GENE THERAPY DISCOVERY |
Construction | NEBuilder® HiFi DNA Assembly Cloning Kit (NEB #E5520) |
| NEBridge® Golden Gate Assembly Kit (NEB #E1601, #E1602) | ||
| Transformation | NEB 5-alpha Competent E.coli (NEB #C2987) | |
| NEB 10-beta Competent E.coli (NEB #C3019) | ||
| NEB Stable Competent E.coli (High Efficiency) (NEB #C3040) | ||
| Nucleic acid removal (AAV) |
NEBExpress® Salt Active Nuclease (NEB #M0764) NEBExpress Salt Active Nuclease, GMP Grade (NEB #G8024) |
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| DNA purification & analysis | Monarch® Spin Plasmid Miniprep Kit (NEB #T1110) | |
| Monarch Spin PCR & DNA Cleanup Kit (NEB #T1130) | ||
| NEBNext® Ultra™ II DNA Library Prep Kit (NEB #E7645) | ||
| NEBNext Companion Module v2 for ONT® (NEB #E7672) | ||
| Template generation | NEBuilder HiFi DNA Assembly Cloning Kit (NEB #E5520) | |
| BspQI (NEB #R0712)/BspQI-HF® (NEB #R3712) | ||
| Q5® Hot Start High-Fidelity 2X Master Mix (NEB #M0494) | ||
| phi29-XT WGA Kit (NEB #E1604) phi29-XT RCA Kit (NEB #E1603) | ||
| TelN Protelomerase (NEB #M0651) | ||
| T5 Exonuclease (NEB #M0663) | ||
PROTEIN/ANTIBODY DISCOVERY |
Construction | NEBuilder HiFi DNA Assembly Cloning Kit (NEB #E5520) |
| NEBridge Golden Gate Assembly (NEB #E1601, #E1602) | ||
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phi29-XT WGA Kit (NEB #E1604) phi29-XT RCA Kit (NEB #E1603) |
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| NEB 5-alpha Competent E.coli (NEB #C2987) | ||
| Expression | PURExpress® In Vitro Protein Synthesis Kit (NEB #E6800) | |
| BL21 (DE3) Competent E.coli (NEB #C2527) | ||
| NEBExpress Cell-free E.coli Protein Synthesis System (NEB #E5360) | ||
| Nucleic acid removal |
NEBExpress Salt Active Nuclease (NEB #M0764) NEBExpress Salt Active Nuclease, GMP Grade (NEB #G8024) |
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| Purification | NEBExpress Ni-NTA Magnetic Beads (NEB #S1423) | |
| NEBExpress Ni Resin (NEB #S1428) | ||
| NEBExpress Ni Spin Columns (NEB #S1427) | ||
NUCLEIC ACID THERAPEUTICS |
Template generation | NEBuilder HiFi DNA Assembly Cloning Kit (NEB #E552) |
| BspQI (NEB #R0712)/BspQI-HF (NEB #R3712) | ||
| Q5 Hot Start High-Fidelity 2X Master Mix (NEB #M0494) | ||
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phi29-XT WGA Kit (NEB #E1604) phi29-XT RCA Kit (NEB #E1603) |
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| TelN Protelomerase (NEB #M0651) | ||
| In vitro transcription (IVT) | HiScribe® T7 High Yield RNA Synthesis Kit (NEB #E2040) | |
| HiScribe T7 mRNA Kit with CleanCap® Reagent AG (NEB #E2080) | ||
| Companion Products: DNase I (NEB #M0303)/DNase I-XT (NEB #M0570) RNase Inhibitor, Murine (NEB #M0314) | ||
| RNA capping | Faustovirus Capping Enzyme (NEB #M2081) | |
| Vaccinia Capping Enzyme (NEB #M2080) | ||
| mRNA Cap 2´-O-Methyltransferase (NEB #M0366) | ||
| Poly(A) tailing | E. coli Poly(A) polymerase (NEB #M0276) | |
| RNA Purification & Analysis |
Monarch Spin RNA Cleanup Kits (10, 50, 500 μg) (NEB #T2030, T2040, T2010) |
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| Monarch Spin RNA Isolation Kit (Mini) (NEB #T2110) |
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| Luna® Probe One-Step RT-qPCR 4X Mix with UDG (NEB #M3019) |
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Biotherapeutic manufacturing/scale-up
NEB’s portfolio of research-grade and GMP-grade* products enables bench to commercial-scale production batch sizes. When it is time to scale up and optimize reaction components, our standalone enzymes and buffers are readily available in formats (ml to kl), enabling a seamless transition to large-scale manufacturing.
| Product name | Gene therapy | Protein/ antibody | mRNA | Available GMP-grade* |
|---|---|---|---|---|
| BspQI (NEB #R0712) | ● | ● | ||
| NEBExpress Salt Active Nuclease (NEB #M0764, #G8024) | ● | ● | ● | |
| TEV Protease (NEB #P8112) | ● | ● | ||
| Thermolabile Proteinase K (NEB #P8111) | ● | |||
| Q5 Hot Start High-Fidelity 2X Master Mix (NEB #M0494) | ● | ● | ||
| HiScribe® T7 High Yield RNA Synthesis Components | ● | ● | ||
| T5 Exonuclease (NEB #M0663) | ● | ● | ||
| TelN Protelomerase (NEB #M0651) | ● | ● | ● | |
| phi29 DNA Polymerase (NEB #M0269) | ● | ● | ● | |
| DNase I-XT (NEB #M0570) | ● | |||
| RNase Inhibitor, Murine (NEB #M0314) | ● | ● |
Biotherapeutic analytical analysis
NEB provides a suite of advanced tools and enzymes designed for precise and accurate biotherapeutic characterization. Our products support various analytical methods, including next-generation sequencing and mass spectrometry, enabling detailed analysis of biomolecules.
| Application | Product Name |
|---|---|
| LC-MS/MS nucleic acid analysis | RNase 4 (NEB #M1284) |
| RNase 4 Digestion and 3´ End Repair Mix (NEB #M1288) | |
| Nucleoside Digestion Mix (NEB #M0649) | |
| Protein analysis | IdeZ Protease (IgG-specific) (NEB #P0770) |
| Trypsin-ultra™, Mass Spectrometry grade (NEB #P8101) | |
| Glycan analysis | PNGase F (NEB #P0704, #P0710, #P0708, #P0711) |
Products and content are covered by one or more patents, trademarks and/or copyrights owned or controlled by New England Biolabs, Inc (NEB). The use of trademark symbols does not necessarily indicate that the name is trademarked in the country where it is being read; it indicates where the content was originally developed. All other trademarks are the property of their respective owners. The use of this product may require the buyer to obtain additional third-party intellectual property rights for certain applications. For more information, please email busdev@neb.com.
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Support for biotherapeutic discovery and manufacturing
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