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  • Protein Tools

    New England Biolabs offers an array of protein tools for all of your protein analysis needs.

    Proteome Analysis

    Trypsin-digested BSA MS Standard (CAM-modified) (NEB #P8108) is a complex mixture of peptides that can be used to calibrate mass spectrometers.


    NEB offers several proteases for proteomics applications, including Trypsin (NEB #P8101), AspN (NEB #P8104), GluC (NEB #P8100), Furin (NEB #P8077) and Thermitase.

    Protein Labeling

    New England Biolabs provides the SNAP-tag®, CLIP-tag™ and ACP/MCP-tag protein labeling systems that facilitate the attachment of virtually any molecule to a protein of interest, and can be used for studying the function and localization of proteins in living and fixed cells, as well as protein immobilization. 

    Phage Display

    The Ph.D.™ libraries from New England Biolabs have become the preeminent tools in this field, with hundreds of publications describing applications, including epitope mapping/vaccine development, mapping protein-protein contacts and identification of peptide mimics of non-peptide ligands. Bioactive peptides, which can be used as cell-targeting or gene delivery agents, have been identified either by panning against purified receptors or against intact cells or tissue samples, both in vitro and in vivo. NEB offers displayed peptide libraries of 7 (NEB #E8100) and 12 (NEB #E8110) residues, as well as a disulfide-constrained 7-residue library (NEB #E8120).  

    Protein Kinases

    The reversible addition of phosphate groups to proteins is important for the transmission of signals within eukaryotic cells and, as a result, protein phosphorylation and dephosphorylation regulate many diverse cellular processes. As the number of known protein kinases has increased at an ever-accelerating pace, it has become more challenging to determine which protein kinases interact with which substrates in the cell. The determination of consensus phosphorylation site motifs by amino acid sequence alignment of known substrates has proven useful in this pursuit. These motifs can be helpful for predicting phosphorylation sites for specific protein kinases within a potential protein substrate. NEB offers a line of several protein kinases to aid in this research.

    Protein Phosphatases

    Protein phosphorylation plays a role in the regulation of the function and activity of protein factors and enzymes. Protein phosphorylation can be found on tyrosine, histidine, serine and threonine residues. Analysis of the presence of such phosphorylation, and its attendant effects, is often aided by removal of the protein phosphate groups by phosphatases. NEB offers several protein phosphatases that remove phosphate groups from different subsets of these residues.

    Protein Markers and Ladders

    NEB offers a selection of highly pure protein markers and ladders, with a size range of 2.3 to 250 kDa, available in unstained, prestained or ColorPlus™ (prestained containing two colored bands for easy identification) formats.

    SNAP-tag® is registered trademark of New England Biolabs, Inc.
    CLIP-tag™, Ph.D.™ and ColorPlus™ are trademarks of New England Biolabs, Inc.

    Protein Tools includes these subcategories:

    Phage Display Information
    Proteases Information
    Protein Kinases Information
    Protein Labeling Information
    Protein Markers & Ladders Information
    Protein Phosphatases Information
    Proteome Analysis

    Protease Selection Chart