Histone H2A combines with Histone H2B to form the H2A-H2B heterodimer. Histone H2A is also modified by various enzymes and these modifications have been shown to be important in gene regulation.
Histone H2A combines with Histone H2B to form the H2A-H2B heterodimer. Two H2A/H2B heterodimers interact with an H3/H4 tetramer to form the histone octamer. (1,2) Histone H2A is also modified by various enzymes and can act as a substrate for them. These modifications have been shown to be important in gene regulation.
Protein Sequence: SGRGK QGGKA RAKAK SRSSR AGLQF PVGRV HRLLR KGNYS ERVGA GAPVY LAAVL EYLTA EILEL AGNAA RDNKK TRIIP RHLQL AIRND EELNK LLGRV TIAQG GVLPN IQAVL LPKKT ESHHK AKGK (Genbank accession number: AAN59960)
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