Histone H1 acts on the linker region of polynucleosome DNA to condense the chromatin into structures of ~30 nm (1). It is not necessary for octamer or nucleosome core particle formation. Eight different Histone H1 proteins have been identified in the human genome (2). Histone H10 is a non replication-dependent histone that is highly expressed in cells that have terminally differentiated (3).
1 mg/ml, 48 µM iscalculated using the molar extinction coefficient for Histone H1 (3840) and itsabsorbance at 280 nm (4,5). 1.0 A280 units = 5.4mg/ml.
There is a small percentage of Histone H10 with a mass of 20863.27 which is a +131 Da difference from the major species. This correlates to Histone H10 with an intact N-terminal methionine (6).
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