
Enrichment
Enrichment methods add efficiency to genomic and epigenomic studies. NEB offers kits and reagents that enable efficient downstream analysis of 5-Methylcytosine (5mC) modified DNA and N6-Methyladenosine (m6A) modified RNA species. Independently applicable, individual reagents complement the EpiMark® kits.

- EpiMark Methylated DNA Enrichment Kit (NEB #E2600) enriches and purifies double-stranded methyl-CpG from fragmented genomic DNA based on the selective and high affinity of the MBD2-Fc fusion protein and magnetic bead capture. Methylated and unmethylated DNA controls are included for qPCR.
- EpiMark N6-Methyladenosine Enrichment Kit (NEB #E1610). N6-Methyladenosine antibody enables immunoprecipitation of m6A modified RNA using magnetic bead capture. Controls for N6-Methyladenosine modified and unmodified RNA are included for monitoring of enrichment and depletion with RT-qPCR.
- Protein A Magnetic Beads (NEB #S1425) are compatible with methylated DNA immunoprecipitation.
- Protein G Magnetic Beads (NEB #S1430) can be used in conjunction with the EpiMark® N6-Methyladenosine Enrichment Kit for isolation of enriched m6A RNA for downstream analysis by next-generation RNA sequencing or RT-qPCR.
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- Comparison of Methods for DNA Methylation Analysis
- EpiMark® Methylated DNA Enrichment Kit Troubleshooting Guide
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