Vaccinia Capping System
NEBU recombinant 37 SAM

GMP-grade reagent also available. Learn more.

Looking for higher capping efficiency and a broader temperature range? Try out new Faustovirus Capping Enzyme.

A full system for enzymatic capping based on the Vaccinia virus Capping Enzyme (VCE)

  • Adds 7-methylguanylate cap structures (Cap-0) to the 5′ end of RNA generated by in vitro transcription
  • Cap-0 is required for efficient translation of the RNA in eukaryotic systems
  • mRNA Cap 2´-O-Methyltransferase (NEB #M0366) is required to generate Cap-1 structure that reduces cellular innate immune response when the RNA is used in vivo
  • Isolated from a recombinant source
  • Tested for the absence of endonucleases, exonucleases, RNases
  • Getting ready to scale up RNA synthesis? Download our new technical note “Scaling of High-Yield In vitro Transcription Reactions for Linear Increase of RNA Production” for a generalized set of recommendations for synthesizing high yields of RNA.
Catalog # Concentration Size List Price Your Price Quantity
M2080S 10,000 units/ml 400 units $147.00
Please enter a quantity for at least one size

Now available as a GMP-grade reagent. Learn more
Need a custom/large volume order? Contact us
Loading Spinner