Thermolabile Exonuclease I
recombinant neb31 37 80 Heat

Interested in a 5-minute protocol? Try out the Exo-CIP Rapid PCR Cleanup Kit (NEB #E1050)

We are excited to announce that we are in the process of switching all reaction buffers to be BSA-free. Beginning April 2021, we will be gradually transitioning to buffers containing Recombinant Albumin (rAlbumin) for restriction enzymes and some DNA modifying enzymes. All information on the website has been updated to reflect this change. Find more details at

  • DNA specific exonuclease
  • Catalyzes the removal of nucleotides from linear single-stranded DNA in the 3' to 5' direction
  • Unlike Exonuclease I (NEB #M0293), Thermolabile Exonuclease I can be heat inactivated at 80°C in 1 minute 

Thermolabile Exonuclease I is ideal for:

  • Removal of single-stranded primers in PCR reactions prior to DNA sequencing or SNP analysis
  • Removal of single-stranded primers for nested PCR reactions
  • Removal of linear single-stranded DNA, leaving behind double-stranded DNA in the sample

Request a copy of our Choosing the Right Exonuclease poster.

Catalog # Concentration Size List Price Your Price Quantity
M0568S 20,000 units/ml 3,000 units $77.00
M0568L 20,000 units/ml 15,000 units $312.00
Please enter a quantity for at least one size

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