icon_NEB2 icon_incTemp37 icon_HI_65 bsa

McrBC is an endonuclease which cleaves DNA containing methylcytosine* on one or both strands. Sites on the DNA recognized by McrBC consist of two half-sites of the form (G/A)mC. These half-sites can be separated by up to 3 kb, but the optimal separation is 55-103 base pairs.

*5-methylcytosine or 5-hydroxymethylcytosine

  • McrBC requires GTP for DNA cleavage
  • Supplied with NEBuffer 2, 100X BSA and 100x GTP


Ordering Information

  • 10,000 units/ml
    500 units
  • 10,000 units/ml
    2,500 units
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