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Cellular Analysis

New England Biolabs provides two different protein labeling systems that facilitate the attachment of virtually any molecule to a protein of interest. SNAP- and CLIP-tag protein labeling systems enable the specific, covalent attachment of virtually any molecule to a protein of interest. There are two steps to using this system: cloning and expression of the protein of interest as a SNAP-tag® fusion, and labeling of the fusion with the SNAP-tag substrate of choice. The SNAP-tag is a small protein based on human O6-alkylguanine-DNA-alkyltransferase (hAGT), a DNA repair protein. SNAP-tag substrates are dyes, fluorophores, biotin, or beads conjugated to guanine or chloropyrimidine leaving groups via a benzyl linker. In the labeling reaction, the substituted benzyl group of the substrate is covalently attached to the SNAP-tag. CLIP-tag™ is a modified version of SNAP-tag, engineered to react with benzylcytosine rather than benzylguanine derivatives. When used in conjunction with SNAP-tag, CLIP-tag enables the orthogonal and complementary labeling of two proteins simultaneously in the same cells. 

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Cellular Analysis

SNAP-tag Substrates Products

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BG-GLA-NHS

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BG-Maleimide

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BG-PEG-NH2

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SNAP-Biotin®

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SNAP-Cell® 505-Star

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SNAP-Cell® Block

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SNAP-Cell® Oregon Green®

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SNAP-Cell® TMR-Star

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SNAP-Cell® 430

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SNAP-Cell® 647-SiR

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SNAP-Surface® 488

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SNAP-Surface® 549

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SNAP-Surface® 594

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SNAP-Surface® 649

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SNAP-Surface® Alexa Fluor® 488

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SNAP-Surface® Alexa Fluor® 546

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SNAP-Surface® Alexa Fluor® 647

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SNAP-Surface® Block

CLIP-tag™ Substrates Products

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CLIP-Biotin

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CLIP-Cell™ 505

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CLIP-Cell™ TMR-Star

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CLIP-Surface™ 488

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CLIP-Surface™ 547

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CLIP-Surface™ 647

SNAP-Capture Products

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SNAP-Capture Magnetic Beads

Blocking Agents Products

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SNAP-Cell® Block

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SNAP-Surface® Block

Cellular Analysis Vectors Products

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pCLIPf Vector

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pSNAPf Vector

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pSNAP-tag® (T7)-2 Vector

Biotin Labels Products

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CLIP-Biotin

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SNAP-Biotin®

Building Blocks Products

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BG-GLA-NHS

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BG-Maleimide

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BG-PEG-NH2

SNAP-tag Other Products

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Anti-SNAP-tag® Antibody (Polyclonal)

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SNAP-tag® Purified Protein

SNAP-tag Substrates Products
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BG-GLA-NHS

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BG-Maleimide

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BG-PEG-NH2

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SNAP-Biotin®

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SNAP-Cell® 505-Star

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SNAP-Cell® Block

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SNAP-Cell® Oregon Green®

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SNAP-Cell® TMR-Star

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SNAP-Cell® 430

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SNAP-Cell® 647-SiR

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SNAP-Surface® 488

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SNAP-Surface® 549

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SNAP-Surface® 594

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SNAP-Surface® 649

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SNAP-Surface® Alexa Fluor® 488

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SNAP-Surface® Alexa Fluor® 546

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SNAP-Surface® Alexa Fluor® 647

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SNAP-Surface® Block

CLIP-tag™ Substrates Products
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CLIP-Biotin

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CLIP-Cell™ 505

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CLIP-Cell™ TMR-Star

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CLIP-Surface™ 488

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CLIP-Surface™ 547

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CLIP-Surface™ 647

SNAP-Capture Products
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SNAP-Capture Magnetic Beads

Blocking Agents Products
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SNAP-Cell® Block

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SNAP-Surface® Block

Cellular Analysis Vectors Products
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pCLIPf Vector

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pSNAPf Vector

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pSNAP-tag® (T7)-2 Vector

Biotin Labels Products
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CLIP-Biotin

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SNAP-Biotin®

Building Blocks Products
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BG-GLA-NHS

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BG-Maleimide

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BG-PEG-NH2

SNAP-tag Other Products
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Anti-SNAP-tag® Antibody (Polyclonal)

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SNAP-tag® Purified Protein