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Researcher Profiles

New England Biolabs has an extensive research program that is at the forefront of the life science industry. Over 30 labs participate in research projects, which are aided by post-doctoral fellows and students in Masters and Ph.D. programs. NEB scientists have authored or co-authored over 1,000 publications (as of 1/17) in a variety of disciplines, including gene expression, chemical biology, parasitology, RNA biology, DNA enzymes and restriction enzymes.

Learn more about the research being conducted by our Senior Scientists in their profiles below.

  • Genome
    Biology


    Genome Biology is life studied from a genomic perspective. The Genome Biology Division focuses on restriction modification, epigenetics, computational biology, NGS technology and human disease (cancer, microbiomes, neglected tropical diseases).

    The laboratories in the Genome Biology Division utilize different approaches to address these research areas, including working on detailed mechanistic studies (biochemistry, structural biology), as well as genome-wide studies looking at genomics and transcriptomics, and developing enabling sequencing technologies.

    1. NEBTV_GenomeBiologyresearch

      Tilde Carlow, Genome Biology Research at NEB

      In this video, Tilde Carlow describes the aims and interests of the Genome Biology Research Division at NEB.

    • TildeCarlow126x126

      Clotilde Carlow

      Scientific Director
      Ph.D., University of London, 1984

      Area of focus:

      Neglected tropical diseases and tick-borne infections

    • BartonSlatko_126x126

      Barton Slatko

      Senior Scientist
      Ph.D., University of Texas, Austin, 1977

      Area of focus:

      Filariasis genomics and Wolbachia symbiosis

    • Geoffrey Wilson

      Geoffrey Wilson

      Scientist Emeritus
      Ph.D., Sussex University, 1976

      Area of focus:

      Restriction enzymes

    • Janos_Posfai

      Janos Posfai

      Senior Scientist
      Ph.D., University of Szeged, 1991

      Area of focus:

      Bioinformatics of restriction enzymes

    • Laurence_Ettwiller

      Laurence Ettwiller

      Senior Scientist
      Ph.D., University of Cambridge, 2005

      Area of focus:

      NGS and computational biology

    • Richard Roberts

      Sir Richard Roberts

      Chief Scientific Officer
      Ph.D., University of Sheffield, 1968

      Area of focus:

      Bioinformatics of restriction and modification

    • Richard Morgan

      Richard Morgan

      Senior Scientist
      Ph.D., Boston University, 2009

      Area of focus:

      Protein Engineering, DNA recognition, R-M systems, genomics

    • Sriharsa Pradhan

      Sriharsa Pradhan

      Distinguished Scientist
      Ph.D., University of Glasgow, 1995

      Area of focus:

      Epigenetic gene regulation and inheritance

  • Molecular
    Enzymology


    The Molecular Enzymology Division use a variety of techniques to ask: 

    • What is the enzyme activity? 
    • What are the most important parts of that enzyme? 
    • How can the enzyme be engineered to have new activities?

    This enables NEB researchers as well as NEB customers to use enzymes in new and creative ways to accelerate both basic research discoveries as well as innovations in biotechnology workflows.

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      Andy Gardner, Molecular Enzymology Research at NEB

      In this video, Andy Gardner describes the aims and interests of the Molecular Enzymology Research Division at NEB.

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      Andrew Gardner

      Scientific Director
      Ph.D., Boston University, 2010

      Area of focus:

      DNA amplification; Genomics

    • Greg_Lohman

      Greg Lohman

      Staff Scientist
      Ph.D., Massachusetts Institute of Technology, 2007

      Area of focus:

      DNA & RNA ligase mechanisms, kinetics and applications

    • Jurate Bitinaite

      Jurate Bitinaite

      Senior Scientist
      Ph.D., Vilnius University, 1986

      Area of focus:

      DNA modification and DNA Repair

    • Lana Saleh

      Lana Saleh

      Senior Scientist
      Ph.D., Pennsylvania State University, 2005

      Area of focus:

      Ten-eleven translocase (TET) proteins

    • Ming-Qun Xu

      Ming-Qun Xu

      Senior Scientist
      Ph.D., State University of New York at Albany, 1989

      Area of focus:

      Protein engineering, protein labeling and imaging

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      Peter Weigele

      Senior Scientist
      Ph.D., University of Utah, 2003

      Area of focus:

      The biochemistry of complex nucleic acid modifications

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      Shuang-yong Xu

      Senior Scientist
      Ph.D., University of Iowa, 1989

      Area of focus:

      Bacterial defense systems including modification-dependent restriction systems

  • Nucleic Acid
    Replication


    The Nucleic Acid Replication Division addresses biological questions related to genome maintenance and replication, and uses technology that’s been developed at NEB to study replication in vivo and in vitro at the single molecule level. They also study replication enzymes, such as DNA polymerases and Reverse Transcriptases. Polymerases are the molecular machines that drive applications in Next Generation Sequencing, molecular diagnostics and synthetic biology, and a better understanding of polymerase enzymology helps improve these applications. Greater knowledge helps to create better enzymes and expands the molecular toolbox available for life science research.
    1. NEBTV_NucleicAcidReplicationResearch

      Jennifer Ong, Nucleic Acid Replication Research at NEB

      In this video, Jennifer Ong describes the aims and interests of the Nucleic Acid Research Division at NEB.

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      Jennifer Ong

      Scientific Director
      Ph.D., University of Cambridge, 2005

      Area of focus:

      DNA polymerases, RNA polymerases, reverse transcriptases, replication fidelity, next-generation sequence, protein engineering

    • Bill Jack

      Bill Jack

      Senior Scientist
      Ph.D., Duke University, 1983

      Area of focus:

      DNA polymerase function

    • Nathan Tanner

      Nathan Tanner

      Staff Scientist
      Ph.D., Harvard University, 2010

      Area of focus:

      Isothermal amplification, molecular diagnostics, single-molecule analysis of replication enzymes

    • Nick

      Shengxi Guan

      Staff Scientist
      PhD., University of Southern California

      Area of focus:

      Reverse transcriptase, genomics and transcriptomics

    • Tom_Evans

      Tom Evans

      Executive Director, Research
      Ph.D., University of Minnesota, 1996

      Area of focus:

      Enzymes and technologies involved in DNA repair and replication

  • Protein Expression
    & Modification


    The Protein Expression and Modification Research department conducts research in two broad areas: 

    • Protein Expression, where the primary focus is improving the process of heterologous protein production in microbes, in particular in E. coli. Host strains are engineered in order to study protein folding.  New and interesting enzymatic activities are discovered through genetic screens and functional metagenomics.
    • Post-translational modification of proteins, to understand oxidative protein folding, in particular the formation of disulfide bonds.  The structure, function and biology of protein-linked glycans is studied with a strong emphasis on improving proteomics and glycomics workflows. Improved workflows are used to study complex biological samples like blood serum and the cell surfaces of mammalian and parasite cells.
     
    1. NEBTV_RS_ProteinExpressionandModification

      Chris Taron, Protein Expression & Modification Research at NEB

      In this video, Chris Taron describes the aims and interests of the Protein Expression & Modification Research Division at NEB.

    • Chris_Taron

      Christopher Taron

      Scientific Director
      Ph.D., University of Illinois, 1999

      Area of focus:

      Protein expression and glycobiology

    • Cristian_Ruse

      Cristian Ruse

      Staff Scientist
      Ph.D. , Case Western Reserve University, 2003

      Area of focus:

      Mass spectrometry and proteomics

    • Jeremy_Foster

      Jeremy M. Foster

      Staff Scientist
      Ph. D., University of Liverpool, 1989

      Area of focus:

      Genomics and glycobiology of filarial nematodes

    • James Samuelson

      James Samuelson

      Senior Scientist
      Ph.D., Ohio State University, 2000

      Area of focus:

      Microbial strain engineering, protein engineering and glycobiology

    • Lise Raleigh

      Elisabeth Raleigh

      Emeritus Scientist
      Ph.D., Massachusetts Institute of Technology, 1981

      Area of focus:

      Adding new genes to bacterial chromosomes and controlling their spread.

    • Mehmet_Berkmen

      Mehmet Berkmen

      Staff Scientist
      Ph.D., University of Vienna, University of Houston, 2000

      Area of focus:

      Strain engineering and disulfide bonded protein folding

  • RNA


    The RNA Research Division works to discover, understand and develop enzymes and workflows to enable RNA research, including:

    • New enzymes and workflows to enable messenger RNA and RNA synthesis, at any scale
    • Enzymes and workflows that are useful to help understand the epitranscriptome
    • RNA-guided nucleases that enable programmable DNA interrogation on demand 

    This research will help guide the future product offerings from New England Biolabs.

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      Brett Robb, RNA Research at NEB

      In this video, Brett Robb describes the aims and interests of the RNA Research Division at NEB.

    • Brett Robb

      Brett Robb

      Scientific Director
      Ph.D., University of Toronto, 2004

      Area of focus:

      RNA-programmed nucleases, mRNA capping

    • BijoyitaRoy_126x126

      Bijoyita Roy

      Staff Scientist
      Ph.D., Univ. of Tennessee, 2010

      Area of focus:

      In vitro synthesis of modified RNA, mRNA synthesis and design, post-transcriptional gene regulation, tools and methods for RNA research, RNA therapeutics.

    • Yigit_Erbay_126x126px

      Erbay Yigit

      Staff Scientist
      Ph.D., University of Massachusetts Medical School, 2007

      Area of focus:

      RNA modifications and RNA-modifying enzymes

    • Ira Schildkraut

      Ira Schildkraut

      Emeritus Scientist
      Ph.D., University of Miami, 1974

      Area of focus:

      Enzymatic manipulation of RNA

    • Ivan Correa

      Ivan Correa

      Senior Scientist
      Ph.D., State University of Campinas, 2003

      Area of focus:

      Nucleic acid modifications, bioorthogonal probes, synthetic chemistry, mass spectrometry.

    • Larry_McReynolds

      Larry McReynolds

      Emeritus Scientist
      Ph.D., Massachusetts Institute of Technology, 1974

      Area of focus:

      Non-coding RNAs and RNA ligases