{title:`Meet the Team`,anchor:`TeamList`,placeholder:null,icon:{src:`/en-us/-/media/nebus/page-images/research-labs/menu-icons/research_icon_team.svg?rev=73efe93f0bba49709f657e78215ed5b0&hash=F698DC7DB644D50105D8C2F7E411E0DA`,alt:`Research_Icon_Team`},teamList:[{memberDescription:`James performed his Ph.D. in Professor Philip Kranzusch’s lab at Harvard Medical Schoo/Dana-Farber Cancer Institute, where he used biochemistry and structural biology to understand the molecular details of mammalian and prokaryotic innate immunity. After finishing his Ph.D., James started at NEB as a Research Scientist in Dr. Mehmet Berkmen’s lab, and developed a new love for bacteriology and the power of genetic selections to uncover new biological phenomena. Through his scientific training, James has become fascinated with host-virus conflict, and the evolution of antiviral immunity. Now as a principal investigator, James and his lab seek to discover new antiphage defense systems in bacteria, and understand how the molecular machines which comprise these immune systems detect and restrict viral infection. Outside of the lab, James lives in Essex with his wife Rachael and their two young children, Finn and Ivy. When he’s not playing trucks on the living room floor, he enjoys baking bread, growing food in his backyard, and drinking the occasional cold beer.`,memberName:`James Eaglesham`,memberTitle:`Staff Scientist`,mediaSrc:`https://media.neb.com/asset/e93007fc-2e97-4bfd-85b9-e65abdb87a0b/Webp_JPG_PSD/James_Eaglesham_sq.webp`,memberEducation:`Ph.D., Harvard Medical School, USA, 2020
M.Phil., Cambridge University, UK, 2016
B.Sc., Cornell University, USA, 2015`,memberLink:{text:`linkedin.com/in/james-eaglesham`,url:`https://www.linkedin.com/in/james-eaglesham-68a9b563/`,target:`_blank`}},{memberDescription:`

Jesse joined the Eaglesham lab in 2023 with an interest in studying antiviral defense systems in microbes and the counter-defense strategies evolved by their viruses. Jesse’s current research interests are shaped by a fascination with the large and metabolically complex viruses of microbial eukaryotes (e.g., “giant viruses”) and bacteria (e.g., “jumbo phage”), and an expanding appreciation for the evolutionary connections between prokaryotic and eukaryotic immune machinery. In the lab, Jesse is applying genomic and metagenomic screening, bioinformatic, and biochemical approaches to discover and understand the mechanisms of microbial defense systems. Jesse completed his Ph.D. in Sean Whelan’s lab at Harvard Medical School, where his research focused on defining new mechanisms of negative-strand RNA virus replication and gene expression, and the structure-function relationships among viral RNA-dependent RNA polymerases. Prior to joining the Eaglesham lab, Jesse completed his postdoctoral training with Lana Saleh at NEB, where he studied phage-encoded glycosyltransferases that install complex sugars onto DNA during hypermodification of viral genomes. Outside of the lab, Jesse lives with his wife Emily in Beverly and enjoys spending time in his home garden and local allotment on the North Shore, experimenting with new recipes in the kitchen, becoming overly invested in football every Fall, and any opportunity to see live music.

ResearchGate: [https://www.researchgate.net/profile/Jesse-Pyle-2]
PubMed: [https://pubmed.ncbi.nlm.nih.gov/term=pyle+jesse+d+%5Bauthor%5D&sort=date]
ORCID: [https://orcid.org/0000-0003-0115-9921]
Email: [jpyle@neb.com]

`,memberName:`Jesse Pyle`,memberTitle:`Research Scientist I`,mediaSrc:`/en-us/-/media/nebus/page-images/research-labs/eaglesham-lab/employees/jesse_pyle.jpg?rev=730e4b2396e241319c94d24ed0d7a53f&sc_lang=en-us&hash=015E78D8B7C27531CA69C400732B8C41`,memberEducation:`Ph.D., Harvard University, USA, 2021
M.Sc., Texas A&M University, USA, 2015
B.Sc, Texas A&M University, USA, 2013
`,memberLink:{text:`linkedin.com/in/jesse-pyle`,url:`https://www.linkedin.com/in/jesse-pyle/`,target:`_blank`}},{memberDescription:`Dallas received his Ph.D from the University of Minnesota in the lab of Dr. Kyle Costa. In the Costa lab, Dallas developed genetic tools to understand how methanogenic archaea adapt and evolve to harsh and constantly changing environments through the process of natural transformation. Throughout his career, Dallas has been fascinated by genetics and how we can leverage these tools to understand the world around us. In the Eaglesham lab, Dallas is using his skills with genetic screens to understand how microbes defend against invading genetics elements, such as bacteriophages. Outside of the lab, Dallas is a lover of nature, art, and most things nerdy. You usually can find him painting his nails with his extensive nail polish collection, creating fantasy worlds for playing dungeons and dragons, or getting purposefully lost in the woods off-roading next to a hiking trail.`,memberName:`Dallas Fonesca`,memberTitle:`Postdoctoral Fellow`,mediaSrc:`https://media.neb.com/asset/fffa745c-d79d-4d1f-804d-d669f6ee8b54/thumbnail/webimage-Dallas_Fonseca_Lab`,memberEducation:`Ph.D., University of Minnesota, USA`,memberLink:{text:`www.linkedin.com/dallas-fonseca`,url:`https://www.linkedin.com/in/dallas-fonseca-247791108/`,target:`_blank`}},{memberDescription:`Selena is a Masters intern, bringing a strong background in molecular cloning and biotechnology to the team. She earned her Master of Science in Microbiology, with a concentration in Applied Molecular Biotechnology, from the University of Massachusetts Amherst. During her graduate research, she successfully cloned and expressed Mycobacterium tuberculosis enzymes HGPRT and IMPDH, contributing to the development of a PRPP assay. Prior to her master's studies, she conducted undergraduate research in parasitology, focusing on the role of DNA polymerase beta in Trypanosoma brucei and its involvement in kDNA replication and repair. She has a well-rounded background in bacterial and parasitic molecular biology, molecular cloning, and genetic modification techniques. Selena is deeply passionate about infectious diseases and immunology, driven by a commitment to advancing scientific research that supports underserved communities. She aspires to use her knowledge to improve access to medical care, vaccines, and essential treatments for those facing barriers due to poverty and healthcare inequities. Beyond the lab, she enjoys spending time outdoors—whether reading, walking, or exploring with her Australian Shepherd, Bear.`,memberName:`Selena Andrade`,memberTitle:`Masters Student`,mediaSrc:`/en-us/-/media/nebus/page-images/research-labs/eaglesham-lab/employees/selena_andrade.jpg?rev=443e0bc000eb4f899a1344670076881f&sc_lang=en-us&hash=227C22CF7E78117BF97830744B26C231`,memberEducation:`M.Sc., University of Massachusetts Amherst, USA, 2025
B.Sc., University of Massachusetts Amherst, USA, 2024`,memberLink:{text:`linkedin.com/in/selena-andrade`,url:`https://www.linkedin.com/in/selena-andrade-694041235/`,target:`_blank`}},{memberDescription:`Brian earned his undergraduate degree in Biology, with a focus on molecular and cell biology, at the University of Texas at Austin. While at UT, he worked primarily in Professor Jeffrey Barrick’s lab, where he collaborated with other undergraduate students to identify novel antimicrobial peptides and engineer plant bacteria to secrete these peptides against plant pathogens. Brian began his time at NEB as a summer student in Dr. Hoong Lim’s lab, which sparked his interest in bacterial anti-phage defense systems and in discovering how to harness them for various applications. Now in the Eaglesham lab, he works on discovering and characterizing novel anti-phage defense systems. Outside of the lab, he lives in Boston and spends his free time playing volleyball, cycling around the city, enjoying walks along the Esplanade, and trying out new restaurants and cafes.`,memberName:`Brian Matibag`,memberTitle:`Summer Student Interns`,mediaSrc:`https://media.neb.com/asset/3b8999f2-37b7-4077-b7b7-62b56714bbbc/thumbnail/webimage-Brian_Matibag_Lab`,memberEducation:`B.Sc, University of Texas, USA, 2024`,memberLink:{text:`linkedin.com/brian-matibag`,url:`https://www.linkedin.com/in/brian-matibag-42b17322b/`,target:`_blank`}}],moreLink:{text:`Meet the Team & Alumni`,url:`/en-us/research-labs/eaglesham-lab/meet-the-team`,target:null}}

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