GeneSpace: A computational platform for enzyme discovery in the era of big data

We developed a web-based bioinformatics platform to allow NEB scientists without a bioinformatics background to conduct genome mining for enzyme discovery. This platform provides a graphic user interface for advanced research bioinformatics tools and will allow users to run gene annotation and search protein homologs and gene neighborhoods on popular protein
databases, large metagenomics datasets, and in-house sequencing datasets that would otherwise be difficult to do for people without bioinformatics training. Many of the tools in GeneSpace are powered by Domainator, a flexible and modular open-source software suite that we developed for domain-based neighborhood and protein search, extraction, and clustering.