FAQ: Do EnClose TelN Protelomerase (NEB #M0768) and TelN Protelomerase (NEB #M0651) digest TelN recognition sequences in supercoiled dsDNA (e.g., plasmid) and/or linear dsDNA?

Yes, EnClose TelN Protelomerase and TelN Protelomerase will digest both supercoiled and linear dsDNA carrying TelN recognition sites.