Yes, APOBEC3A has sequence preference for TC > CC > GC > AC 1, 2, 3, where the underlined C is the targeted cytosine for deamination in the dinucleotide. In order to provide robust activity on all substrates, the least preferred substrate, an AC motif, was used for the unit definition.
- Silvas, TV. et. al. Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions. (2018) Sci Rep. 8, 7511. https://doi.org/10.1038/s41598-018-25881-z.
- Stenglein, M. et. al. APOBEC3 proteins mediate the clearance of foreign DNA from human cells. (2010) Nat. Struct. Mol. Biol. 14, 222-229. https://doi.org/10.1038/nsmb.1744.
- Vartanian, JP. et. al. Evidence for Editing of Human Papillomavirus DNA by APOBEC3 in Benign and Precancerous Lesions. (2008) Science. 320, (5873) 230-233. https://doi.org/10.1126/science.1153201.
