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DNA Enrichment

Methyl-DNA immunoprecipitation (Me-DIP) and Methyl-CpG Binding Domain (MBD) -based capture are both effective methods to enrich methylated DNA from genomic DNA samples. However, for genome-wide methylation analysis, these two methods have differing CpG density bias. Me-DIP favors low methyl CpG density whereas MBD favors higher methyl CpG density (1). Both methods can be used upstream of microarray or sequencing analysis.

 
  1. Shalima S. Nair et al. (2011) Epigenetics 6:1,34-44. PMID: 20818161

Protocols for DNA Enrichment

    Other Tools & Resources

    Brochures

  • Epigenetics Brochure

    The Epigenetics brochure provides information on these unique solutions to study DNA and histone modifications. NEB offers a suite of validated products for epigenetics research.

    Publications related to DNA Enrichment

  1. Wee E., Ngo T., Trau M. 2015. A simple bridging flocculation assay for rapid, sensitive and stringent detection of gene specific DNA methylation Sci Rep. 5, PubMedID: 26458746, DOI: 10.1038/srep15028

Overview EpiMark® Methylated DNA Enrichment Kit

Legal Information

This product is covered by one or more patents, trademarks and/or copyrights owned or controlled by New England Biolabs, Inc (NEB).

While NEB develops and validates its products for various applications, the use of this product may require the buyer to obtain additional third party intellectual property rights for certain applications.

For more information about commercial rights, please contact NEB's Global Business Development team at gbd@neb.com.

This product is intended for research purposes only. This product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.

  1. What is Epigenetics?

    What Is Epigenetics?

    If all cells are created from the same genetic material, why are there so many different cell types? Listen to Sriharsa Pradhan, Senior Scientist, RNA Biology at NEB, as he describes how DNA is methylated and how this affects the path of reading the DNA code the same way an obstruction would derail a train off its tracks.