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DNA Enrichment

Methyl-DNA immunoprecipitation (Me-DIP) and Methyl-CpG Binding Domain (MBD) -based capture are both effective methods to enrich methylated DNA from genomic DNA samples. However, for genome-wide methylation analysis, these two methods have differing CpG density bias. Me-DIP favors low methyl CpG density whereas MBD favors higher methyl CpG density (1). Both methods can be used upstream of microarray or sequencing analysis.

 
  1. Shalima S. Nair et al. (2011) Epigenetics 6:1,34-44. PMID: 20818161

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Protocols for DNA Enrichment

    Other Tools & Resources

    Brochures

  • Epigenetics Brochure

    The Epigenetics brochure provides information on these unique solutions to study DNA and histone modifications. NEB offers a suite of validated products for epigenetics research.

    Publications related to DNA Enrichment

  1. Wee E., Ngo T., Trau M. 2015. A simple bridging flocculation assay for rapid, sensitive and stringent detection of gene specific DNA methylation Sci Rep. 5, PubMedID: 26458746, DOI: 10.1038/srep15028

Overview EpiMark® Methylated DNA Enrichment Kit