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We believe that basic research and the cultivation of scientific knowledge is critical for us to stay connected with our customers and to drive scientific breakthroughs. At NEB, over 30 labs participate in research projects, which are aided by post-doctoral fellows and students in Masters and Ph.D. programs. NEB researchers have authored or co-authored over 1,000 publications (as of 1/17) many of which are in peer-reviewed journals. Further, NEB products have been used successfully in numerous publications by scientists throughout the world.

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Year Title Journal Authors Application(s)
1997 The Tsp45I restriction-modification system is plasmid-borne within its thermophilic host. Gene Wayne, J., Holden, M., and Xu, S.Y.
1997 Structure of the Multimodular Endonuclease FokI Bound to DNA. Nature Wah, D.A., Hirsch, J.A., Dorner, L.F., Schildkraut, I., Aggarwal, A.K.
1997 Protein Splicing of the Saccharomyces cerevisiae VMA Intein without the Endonuclease Motifs*. J Biol.Chem. Chong, S., and Xu, M.Q.
1997 REBASE-restriction enzymes and methylases. Nucl.Acids Res. Roberts, R.J.and Macelis, D.
1997 Single-column purification of free recombinant proteins using a self-cleavable affinity tag derived from a protein splicing element. Gene Chong, S., Mersha, F.B., Comb, D.G., Scott, M.E., Landry, D., Vence, L.M., Perler, F.B., Benner, J., Kucera, R.B., Hirvonen, C.A., Pelletier, J.J., Paulus, H., and Xu, M.Q.
1997 Discovery and Uses of Novel Glycosidases Techniques in Glycobiology Wong-Madden, S.T., Landry, D., and Guthrie, E.P. Glycobiology
1997 DNA containing 4'-thio-2' deoxycytidine inhibits methylation by HhaI methyltransferase. Nucl.Acids Res. Kumar, S., Horton, J.R., Jones, G.D., Walker, R.T., Roberts, R.J., and Cheng, X.
1997 Homing endonucleases: keeping the house in order. Nucl.Acids Res. Belfort, M., and Roberts, R.J.
1998 McrBs, a modulator peptide for McrBC activity. EMBO J. Panne, D., Raleigh E.A., Bickle, T.A.
1998 Isolation, Characterization and Baculovirus-Mediated Expression of the cDNA Encoding Cytosine DNA Methyltransferase from Pisum Sativum. Nuc.Acids Res. Pradhan, S., Cummings, M., Roberts, R.J.and Adams, R.L.P.
1998 Mu-Opioid Receptor Activates Signaling Pathways Implicated In Cell Survival And Translational Control. J.Biol.Chem. Polakiewicz, R.D., Schieferl, S.M., Gingras, A-C., Sonenberg, N.and Comb, M.J.
1998 Modulation of protein splicing of the saccharomyces cerevisiae vacuolar membrane ATPase intein. J.Biol.Chem. Chong, S., Williams, K.S., Wotkowicz, C.and Xu, M.Q.
1998 FokI Dimerization is Required for DNA Cleavage. Proc.Natl.Acad.Sci.USA Bitinaite, J., Wah, D.A., Aggarwal, A.K., Schildkraut, I.
1998 Drosophila Hormone Receptor 38 Functions in Metamorphosis: A Role in Adult Cuticle Formation. Genetics Kozlova, T., Pokholkova, G.V., Tzertzinis, G., Sutherland, J.D., Zhimulev, I.F.and Kafatos, F.C.
1998 Does Bcg1, a Unique Restriction Endonuclease, Require Two Recognition Sites for Cleavage? J Biol.Chem Kong, H., and Smith, C.L.
1998 Evolutionary evidence for recombination among bacteria in nature.E.coli. Horizontal Gene Transfer Milkman, R., Cryderman, D., McKane, M., McWeeny, K.and Raleigh E.A.
1998 Evaluation of the ASSURE/FH Antibody Assay for the Detection of Feline Heartworm Infection. Proc.Amer.Heartworm Symp. Bestul, K.J., McCall, J.W., Supakorndej, N., Ma, D., Carlow, C.K.S.
1998 Novel, sensitive and low-cost diagnostic tests for "river blindness" - detection of specific antigens in tears, urine and dermal fluid. Trop.Med.Inter.Health Ngu, J.L., Knenfou, C., Capuli, E., McMoli, T.E., Perler, F., Mbwagbor, J., Tumme, C., Nlatte, O.B., Donfack, J.and Asonganyi, T.
1998 Sequence Comparison of the EcoHK31I and EaeI Restriction-Modification Systems Suggests an Intergenic Transfer of Genetic Material. Biol.Chem. Lee, K-F, Shaw, P-C, Picone, S.J., Wilson, G.G.and Lunnen, K.D.
1998 Semisynthesis of cytotoxic proteins using a modified protein splicing element. Protein Sci. Evans, T.C., Benner, J.and Xu, M-Q
1998 Structure of FokI has Implications for DNA Cleavage. Proc.Natl.Acad.Sci.USA Wah, D.A., Bitinaite, J., Schildkraut, I., Aggarwal, A.K.
1998 Site-directed Mutagenesis of Essential Residues Involved in the Mechanism of Bacterial Glycosylasparaginase. J.Biol.Chem. Liu, Y., Guan, C.and Aronson, N.N., Jr.
1998 Restriction Modification Systems: Where They Are and What They Do. Bacterial Genomes Raleigh, E.A.and Brooks, J.E
1998 Protein trans-splicing and functional mini-inteins of a cyanobacterial dnaB intein. Biochim.et Biophys.Acta Wu, H., Xu, M-Q and Liu, X-Q
1998 Protein Splicing of inteins and hedgehog autoproteolysis: structure, function and evolution. Cell Perler, F.B.
1998 Regulation of the p70 S6 Kinase by Phosphorylation in Vivo. J.Biol.Chem. Weng, Q.-P., Kozlowski, M., Belham, C., Zhang, A., Comb, M.J., Avruch, J.
1998 REBASE-restriction enzymes and methylases. Nucl.Acids Res. Roberts, R.J.and Macelis, D.
1998 Discovery and Uses of Novel Glycosidases Techniques in Glycobiology Wong-Madden, S.T., Landry, D., and Guthrie, E.P.
1998 Base Flipping. Annual Review Biochem. Roberts, R.J.and Cheng, X.
1998 Asp34 of PvuII Endonuclease is Directly Involved in DNA Minor Groove Recognition and Indirectly Involved in Catalysis. J.Mol.Biol. Horton, J.R., Nastri, H.G., Riggs, P.D.and Cheng, X.
1998 Characterization and functional analysis of the cis-autoproteolysis active center of glycosylasparaginase. J.Biol.Chem. Guan, C., Liu, Y., Shao, Y., Cui, T., Liao, W., Ewel, A., Whitaker, R.and Paulus, H.
1998 Breaking up is easy with esters [news; comment]. Nature Struct.Biol. Perler, F.B.
1998 Analyzing the Functional Organization of a Novel Restriction Modification System, the BcgI System. J.Mol.Biol. Kong, H
1998 A highly conserved large molecular weight cyclophilin of filarial parasites. Exp.Parasitol. Hong, X., Ma, D., Page, A.P., Kumar, S.and Carlow, C.K.S.
1998 Active site mutants of a cyclosporin A-insensitive cyclophilin from Brugia malayi: effect on catalysis and drug binding. Mol.Biochem.Parasitol. Ma, D.and Carlow, C.K.S.
1998 A Mitogen-activated Protein Kinase Pathway is Required for mu-Opioid Receptor Desensitization. J Biol Chem. Polakiewicz, R.D., Schieferl, S.M., Dorner, L.F., Kansra, V.and Comb, M.J.
1998 Characterization of an Extremely Thermostable Restriction Enzyme, PspGI, from a Pyrococcus Strain and Cloning of the PspGI Restriction-Modification System in Escherichia coli. Appl.Environ.Microbiol. Morgan, R., Xiao, J.P.and Xu, S.Y.
1998 Crystal Structures of Flavobacterium Glycosylasparaginase. J.Biol.Chem. Guo, H.-C., Xu, Q., Buckley, D.and Guan, C.
1998 Crystal Structure of the Cyclophilin-like Domain from the Parasitic Nematode Brugia Malayi. Protein Sci. Mikol, V., Ma, D., Carlow, C.K.S.
1998 Determination of Certain Agarose-Immobilized Ligands by Use of Perchloric Acid. Biochromatography Wilkie, S.D.and Landry, D.
1998 Dependence of McrBC Cleavage on Distance Between Recognition Elements. Biol.Chem. Stewart, F.J.and Raleigh, E.A.
1998 Crystal Structure of the Complex of Brugia Malayi Cyclophilin and Cyclosporin A. Biochemistry Ellis, P.J., Carlow, C.K.S., Ma, D.and Kuhn, P.
1998 Cloning and expression of the ApaLI, NspI, NspHI, SacI, ScaI and SapI restriction-modification systems in Escherichia coli Mol.Gen.Genet. Xu, S.Y., Xiao, Ettwiller L., holden, M., Aliotta, J., Poh, C.L., Dalton, M., Robinson, D.P., Petronzio, T.R., Moran, L., Ganatra, M., Ware, J., Slatko, B.and Benner, J.
1998 Chemical display of thymine residues flipped out by DNA methyltransferases. Nucl.Acids Res. Serva, S., Weinhold, E., Roberts R.J.and Klimasauskas S.
1998 Crystal Structure of Restriction Endonuclease BgII Bound to its Interrupted DNA Recognition Sequence. EMBO J. Newman, M., Lunnen, K., Wilson, G., Greci, J., Schildkraut, I., Phillips, S.E.
1998 Cloning, expression and characterization of a new filarial cyclophilin. Mol.Biochem.Parasitol. Hong, X., Ma, D.and Carlow, C.K.S.
1998 The Maltoxe-Binding Protein as a Scaffold for Monovalent Display of Peptides Derived from Phage Libraries. Anal.Biochem. Zwick, M.B., Bonnycastle, L.L.C., Noren, K.A., Venturini, S., Leong, E., Barbas, C.F., Noren, C.J.and Scott, J.K.
1998 Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nature Struct.Biol. O'Gara, M., Horton, J.R., Roberts, R.J.and Cheng, X.
1998 Utilizing the C-terminal cleavage activity of a protein splicing element to purify recombinant proteins in a single chromatographic step. Nucl.Acids Res. Chong, S., Montello, G.E., Zhang, A., Cantor, E.J., Liao, W., Xu, M.-Q.and Benner, J.
1998 How is modification of the DNA substrate recognized by the PvuII restriction endonuclease? Biol. Chem. Horton, J.R., Bonventre, J. and Cheng, X.
1999 Purification and crystallization of precursors and autoprocessed enzymes of Flavobacterium glycosylasparaginase: an N-terminal nucleophile hydrolase. Acta Crystallogr.D.Biol.Crystallogr. Cui, T., Liao, P.H., Guan, C.and Guo, H.C.
1999 Protein-Modulated DNA Electron Transfer. J.Am.Chem.Soc. Rajski, S.R., Kumar, S., Roberts, R.J.and Barton, J.K.
1999 Parasitic helminth genomics. Exp.Parasitol. Blaxter, M., Aslett, M., Guiliano, D., Daub, J.and The Filarial Genome Project
1999 Mutations of endo-B-N-acetylglucosaminidase H active site residues Asp130 and Glu132: Activities and conformations. Protein Sci. Rao, V., Cui, T., Guan, C., and Van Roey, P.
1999 "Protein Splicing" The Encyclopedia of Molecular Biology Perler, F.B., Xu, M.and Noren, C.J.
1999 Plasmodium vivax, P.cynomolgi, and P.knowlesi: Identification of Homologue Proteins Associated with the Surface of Merozoites. Exp.Parasitol. Barnwell, J.W., Galinski, M.R., DeSimone, S.G., Perler, F.and Ingravallo, P.
1999 Molecular evolution of the Escherichia coli chromosome.V.Recombination patterns among strains of diverse origin. Genetics Milkman, R., Raleigh, E.A., McKane, M., Cryderman, D.and Pohlman, K.
1999 Characterization of a self-splicing mini-intein and its conversion into autocatalytic N- and C-terminal cleavage elements: facile production of protein building blocks for protein ligation. Gene Mathys, S., Evans, T.C., Chute, I.C., Wu, H., Chong, S., Benner, J., Liu, X.Q.and Xu, M.Q.
1999 Alternative splicing creates sex-specific transcripts and truncated forms of the furin protease in the parasite Dirofilaria immitis. Gene Jin, J., Poole, C.B., Slatko, B.E.and McReynolds, L.A.
1999 Crystallization and preliminary diffractin analysis of the HincII restriction endonuclease-DNA complex. Acta Crystallogr.D.Biol.Crystallogr. Horton, N.C, Dorner, L.F., Schildkraut, I.and Perona J.J.
1999 Chemiluminescent Detection of Sequential DNA Hybridizations to High-Density, Filter-Arrayed cDNA Libraries: A Subtraction Method for Novel Gene Discovery. BioTechniques Guiliano, D., Ganatra, M., Ware, J., Parrot, J., Daub, J., Moran, L., Brennecke, H., Foster, J.M., Supali, T., Blaxter, M., Scott, A.L., Williams, S.A.and Slatko, B.E.
1999 A natural example of protein trans-splicing. TIBS Perler, F.B.
1999 A Mutant of BamHI Restriction Endonuclease which Requires N6-Methyladenine for Cleavage. J.Mol.Biol. Whitaker, R.D., Dorner, L.F.and Schildkraut, I.
1999 Deep within the Filarial Genome: Progress of the Filarial Genome Project. Parasitology Today The Filarial Genome Project
1999 Intein-Mediated Protein Ligation: Harnessing Nature's Escape Artists. Biopolymers Evans, T.C.and Xu, M-Q
1999 InBase, the New England Biolabs Intein Database. Nuc.Acids Res. Perler, F.B.
1999 Molecular characterization of FKBP13 from filarial parasites. Mol.Biochem.Parasitol. Ma, D.and Carlow, C.K.S.
1999 KDR Activation in Astrocytic Neoplasms. Cancer Carroll, R.S., Zhang, J., Bello, L., Melnick, M.B., Maruyama, T.and Black, P.M.
1999 Human DNA (Cytosine-5) Methyltransferase.II.steady-state kinetics reveal allostericactivation by methylated DNA. J.Biol.Chem. Bacolla, A., Pradhan, S., Roberts, R.J.and Wells, R.D.
1999 Effect of CWG methylation on expression of plant genes. Biochem J. Pradhan, S., Urwin, N.A., Jenkins, G.I.and Adams, R.L.
1999 Determinants of nucleotide sugar recognition in an archaeon DNA polymerase. Nuc.Acids Res. Gardner, A.F.and Jack, W.E.
1999 Genomics and the biology of parasites. BioEssays Johnston, D.A., Blaxter, M.L., Degrave, W.M., Foster, J., Ivens, A.C.and Melville, S.E.
1999 Genetic Analysis of the Base-specific Contacts of BamHI Restriction Endonuclease. J.Mol.Biol. Dorner, L.F., Bitinaite, J., Whitaker, R.D.and Schildkraut, I.
1999 Wolbachia genomes and the many faces of symbiosis. Parasitology Today Bandi, C., Slatko, B.and O'Neill, S.L.
1999 The Nuclear Receptor Superfamily Has Undergone Extensive Proliferation and Diversification in Nematodes. Genome Res. Sluder, A.E., Mathews, S.W., Hough, D., Yin, V.P.and Maina, C.V.
1999 The McrBC Endonuclease Translocates DNA in a Reaction Dependent on GTP Hydrolysis. J.Mol.Biol. Panne, D., Raleigh E.A.and Bickle, T.A.
1999 Thermal Asymmetric Interlaced PCR Amplification of YAC Insert End Fragments for Chromosome Walking in Plasmodium falciparum and Other A/T-Rich Genomes. BioTechniques Foster, J.M., Christodoulou, Z., Cowan, G.M.and Newbold, C.I.
1999 The Wolbachia Genome Consortium. Microbiol.and Comparative Genomics Slatko, B.E., O'Neill, S.L., Scott, A.L., Werren, J.L., Blaxter, M.L.and the Wolbachia genome Consortium
1999 The kinetic mechanism of EcoRI endonuclease. J.Biol.Chem. Wright, D.J., Jack, W.E.and Modrich P.
1999 Structures of a Binary Complex of HhaI Methyltransferase with S-adenosyl-L-methionine Formed in the Presence of a Short Non-specific DNA Oligonucleotide. J.Mol.Biol. O'Gara, M., Zhang, X., Roberts, R.J.and Cheng, X.
1999 Structural Insights into the Mechanism of Intramolecular Proteolysis. Cell Xu, M.Q., Buckley, D., Guan, C.and Guo, H-C
1999 The in Vitro Ligation of Bacterially Expressed Proteins Using an Intein from Methanobacterium thermoautotrophicum. J.Biol.Chem. Evans, T.C., Benner, J.and Xu, M-Q
1999 The Cyclization and Polymerization of Bacterially Expressed Proteins Using Modified Self-splicing Inteins. J.Biol.Chem. Evans, T.C., Benner, J.and Xu, M-Q
1999 Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes & Devel. Gingras, A-C., Gygi, S.P., Raught, B., Polakiewicz, R.D., Abraham, R.T., Hoekstra, M.F., Aebersold, R.and Sonenberg, N.
1999 Recombinant Human DNA (Cytosine-5) Methyltransferase.I.expression, purification, and comparison of de novo and maintenance. J.Biol.Chem. Pradhan, S., Bacolla, A., Wells, R.D.and Roberts, R.J.
1999 REBASE-restriction enzymes and methylases. Nucl.Acids Res. Roberts, R.J.and Macelis, D.
1999 Purification of Proteins Fused to Either the Amino or Carboxy Terminus of the Mycobacterium xenopi Gyrase A Intein. Cloning and Expression vectors for Gene Function Analysis Southworth, M.W., Amaya, K., Evans, T.C., Xu, M.Q.and Perler, F.B.
2000 A simple in vitro Tn7-based transposition system with low target site selectivity for genome and gene analysis. Nucl.Acids Res. Biery, M.C., Stewart, F.J., Stellwagen, A.E., Raleigh, E.A.and Craig, N.L.
2000 Characterization of the Specific DNA Nicking Activity of Restriction Endonuclease N.BstNBI. Biol.Chem. Morgan, R., Calvet, C., Demeter, M., Agra, R.and Kong, H.
2000 An alternative protein splicing mechanism for inteins lacking an N-terminal nucleophile. EMBO J. Southworth, M.W., Benner, J.and Perler, F.B.
2000 Cloning, Expression and Purification of a Thermostable Nonhomodimeric Restriction Enzyme, BslI J.Bacteriol. Hsieh, P.-C., Xiao, J.-P., O'Loane, D.and Xu, S.-Y.
2000 Functional analysis of putative restriction-modification system genes in the Helicobacter pylori J99 genome. Nucl.Acids Res. Kong, H., Lin, L.F., Porter, N., Stickel, S.Byrd, D., Posfai, J.and Roberts R.J.
2000 Expression and purification of recombinant proteins by fusion to maltose-binding protein. Mol.Biotechnol. Riggs, P.
2000 Fusions to Self-Splicing Inteins for Protein Purification. Methods in Enzymology Xu, M.Q., Paulus, H.and Chong, S.
2000 Dissecting the Chemistry of Protein Splicing and its Applications Angew.Chem.Int.Ed. Noren, C.J., Wang, J.and Perler, F.B.
2000 Crystal Structure of the Complex of Brugia Malayi Cyclophilin and Cyclosporin A. Protein Sci. Ellis, P.J., Carlow, C.K.S., Ma, D.and Kuhn, P.
2000 Construction and use of pIII-displayed peptide libraries Phage Display: A Laboratory Manual Noren, K.A., Saltman, L.H.and Noren, C.J.
2000 Crystallization of Restriction Endonuclease BamHI with Nonspecific DNA. J.Struct.Biol. Viadiu, H., Kucera, R., Schildkraut, I.and Aggarwal, A.K.
2000 Crystallization and preliminary X-ray diffraction analysis of MspI restriction endonuclease in complex with its cognate DNA. Acta Crystallogr.D.Biol.Crystallogr. O'Loughlin, T.J., Xu, Q., Kucera, R.B., Dorner, L.F., Sweeney, S., Schildkraut, I.and Guo, H.-C.
2000 Identification of the Metal-Binding Sites of Restriction Endonucleases by Fe2+-Mediated Oxidative Cleavage. Biochemistry Hlavaty, J.J., Benner, J.S., Hornstra, L.J.and Schildkraut, I.