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We believe that basic research and the cultivation of scientific knowledge is critical for us to stay connected with our customers and to drive scientific breakthroughs. At NEB, over 30 labs participate in research projects, which are aided by post-doctoral fellows and students in Masters and Ph.D. programs. NEB researchers have authored or co-authored over 1,000 publications (as of 1/17) many of which are in peer-reviewed journals. Further, NEB products have been used successfully in numerous publications by scientists throughout the world.

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Year Title Journal Authors Application(s)
2011 Comparitive characterization of the PvuRts11 family and application in mapping genomic 5-hydroxymethylcytosine Nucl. Acids Res.
2015 Restriction Cascade Exponential Amplification (RCEA) assay with an attomolar detection limit: a novel, highly specific, isothermal alternative to qPCR Scientific Reports
Optimization of Medium Composition for Production pf Recombinant
The level of synthesis and secretion of Gaussia princeps
Targeting of tumor blood vessels
Rapid Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components
waffles
Culture-independent genomic characterisation of Candidatus Chlamydia
Efficient DNA ligation in DNA-RNA hybrid helices by Chlorella
2014 Enhanced gene disruption by programmable nucleases delivered by a minicircle vector. Gene Ther A-Bk Dad, S Ramakrishna, M Song, H Kim Genome Editing
2015 Label-free single-cell protein quantification using a drop-based mix-and-read system. Sci. Rep. Abbaspourrad A, Zhang H, Tao Y, Cui N, Asahara H, Zhou Y, Yue D, Koehler SA, Ung LW, Heyman J, Ren Y, Ziblat R, Chong S, Weitz DA.
2014 Modular assembly of designer PUF proteins for specific post-transcriptional regulation of endogenous RNA J Biol Eng Abil Z, Denard CA, Zhao H DNA Assembly and Cloning,Golden Gate Assembly
1992 Identification of surrogate rodent hosts for larval Onchocerca lienalis and induction of protective immunity in a model system. J Parasitol. Abraham, D., Eberhard, M.L., Lange, A.M., Yutanawiboonchai, W., Perler, F.B.and Lok, J.B.
2002 Development of a Positive Genetic Selection System for Inhibition of Protein Splicing Using Mycobacterial Inteins in Escherichia coli DNA Gyrase Subunit A. J.Mol.Micro.Biotechnol. Adam, E.and Perler, F.B.
2008 Cellular Ser/Thr-kinase assays using generic peptide substrates Curr. Chem. Gen. Adams D. G. et al.
1995 Extremozymes: expanding the limits of biocatalysis. Biotechnology Adams, M.W.W., Perler, F.B.and Kelly, R.M.
1996 Plant methyltransferases and thier targets in the plant genome. In: Epigenetic Mechanisms of Gene Regulation Cold Spring Habor Laboratory Press Adams, R.L.P. Pradhan, S., Johnson, C.A, Lindsay, H., Shek, E.W.L., Jenkins, G.I., Urwin, N.A.R.
2013 The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line Nature Adey, A. et al.
2009 The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription  Nucleic Acids Res. adr, C.E., Hewett, J.W., Breakefield, X.O. and Tannous, B.A.
2016 Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells Genes & Dev Agger, K. et al.
2016 Training the Next Generation of Biomedical Investigators in Glycosciences. J. Clin. Invest. Agre, P., Bertozzi, C., Bissell, M., Campbell, K., Cummings, R., Desai, U., Estes, M., Flotte, T., Fogleman, G.,Gage, F., Ginsburg, D., Gordon, J.I., Hart, G., Hascall, V., Kiessling, L., Kornfeld, S., Lowe, J., Magnani, J., Mahal, L.K., Medzhitov, R., Roberts, R., Sackstein, R., Sarkar, R., Schnaar, R., Schwartz, N., Varki, A., Walt, D., Weissman, I.
2009 A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids PLoS One Ahier A. et al.
2012 A terracotta bio-battery Bioresour Technol Ajayi, F.F., Weigele, P.R.
2015 Differential connectivity of splicing activators and repressors to the human spliceosome Genome Biol. Akerman, M., Fregoso, Ol., Das, S., Ruse, C., Jensen, M.A., Pappin, D.J., Zhang, M.Q., Krainer, A.R.
2016 Comprehensive Profiling of Glycosphingolipid Glycans Using a Novel Broad Specificity Endoglycoceramidase in a High-Throughput Workflow. Albrecht, S., Vainauskas, S., Stöckmann, H., McManus, C., Taron, C.H. and Rudd, P.M.
2013 GoldenBraid 2.0: A Comprehensive DNA Assembly Framework for Plant Synthetic Biology Plant Physiology Alejandro Sarrion-Perdigones, Marta Vazquez-Vilar, Jorge Palací, Bas Castelijns, Javier Forment, Peio Ziarsolo, José Blanca, Antonio Granell, Diego Orzaez Golden Gate Assembly
2014 Polynucleotide 3'-terminal phosphate modifications by RNA and DNA ligases Journal of Biological Chemistry Alexander M. Zhelkovsky and Larry A. McReynolds
2015 Expanding the MDx toolbox for filarial diagnosis and surveillance Trends Parasitol. Alhassan, A., Li, Z., Poole, C.B. and Carlow, C.K.S.
2014 A simple isothermal DNA amplification method to screen black flies for Onchocerca Volvulus infection PLoS One Alhassan, A., Makepeace, B.L., LaCourse, E.J., Osei-Atweneboana, M.Y., Carlow, C.K.S.
2016 Comparison of a new visual isothermal nucleic acid amplification test with PCR and skin snip analysis for diagnosis of onchocerciasis in humans. Mol Biochem Parasitol. Alhassan, Aa, Osei-Atweneboana, M.Y., Kyeremeh, K.F., Poole, C.B., Li, Z., Tettevi, E., Tanner, N.A. and Carlow, C.K.
1996 Thermostable Bst DNA polymerase I lacks a 3' fwdarw 5' proofreading exonuclease activity1. Genetic Analysis Biomolecular Engineering Aliotta, J.M., Pelletier, J.J., Ware, J.L., Moran, L.S., Benner, J.S., and Kong, H.
2013 Fully assembled genome sequence for Salmonella enterica subsp. Enterica Serovar Javiana CFSAN001992.  Genome Announcements Allard, M.W. Muruvanda, T., Strain, E., Timme, R., Luo, Y., Wang, C., Keys, C.E., Payne, J., Cooper, T. Luong, K., Song, Y., Chin, C.-S., Korlach, J., Roberts, R.J., Evans, P., Musser, S.M., Brown, E.W.
2015 A New Approach to Produce HIV-1 Envelope Trimers: BOTH CLEAVAGE AND PROPER GLYCOSYLATION ARE ESSENTIAL TO GENERATE AUTHENTIC TRIMERS. J Biol Chem AlSalmi W., Mahalingam M., Ananthaswamy N., Hamlin C., Flores D., Gao G., Rao V.B.
2015 Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters DNA methyltransferase (dnmt) expression in zebrafish (Danio rerio) Toxicol Appl Pharmacol Aluru N, Kuo E, Helfrich LW, Karchner SI, Linney EA, Pais JE, Franks DG
1996 Comparative analysis of expression of the SalI restriction-modification system in Escherichia coli and Streptomyces Mol. Gen. Genet. Alvarez, M.A., Gomez, A., Gomez, P., Brooks, J.E., Rodicio, M.R.
2010 Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET J. Biol. Chem. Alvarez-Curto J. et al.
2015 Rational design of 'controller cells' to manipulate protein and phenotype expression. Metab Eng Amin Zargar, David N Quan, Milad Emamian, Chen Yu Tsao, Hsuan-Chen Wu, Chelsea R Virgile, William E Bentley High-Fidelity PCR
2005 Chracterization of a thermostable UvrD helicase and its participation in helicase-dependent amplification. J.Biol.Chem. An.L., Tang, W., Ranalli, T.A., Kim, H-J., Wytiaz, J.and Kong, H.
2013 Hedgehog Signaling Regulates MyoD Expression and Activity J Biol Chem Anastassia Voronova Erin Coyne, Ashraf Al Madhoun, Joel V. Fair, Neven Bosiljcic, Catherine St-Louis, Grace Li, Sherry Thurig, Valerie A. Wallace, Nadine Wiper-Bergeron, and Ilona S. Skerjanc
2013 DNMT1-interacting RNAs block gene-specific DNA methylation Nature Annalisa Di Ruscio, Alexander K. Ebralidze, Touati Benoukraf, Giovanni Amabile, Loyal A. Goff, Jolyon Terragni, Maria Eugenia Figueroa, Lorena Lobo De Figueiredo Pontes, Meritxell Alberich-Jorda, Konstantin K. Ebralidze, Sriharsa Pradhan, John L. Rinn, Daniel G. Tenen
2013 Segregation of Family A G Protein Coupled Receptor Protomers in the Plasma Membrane Molecular Pharmacology Anthony Gavalas, Tien-Hung Lan, Qiuju Liu, Ivan R. Corrêa, Jr., Jonathan A. Javitch, and Nevin A. Lambert
2014 Objective: biochemical function Front Genet Anton BP, Kasif S, Roberts RJ, Steffen M
2013 The COMBREX project design methodology and initial results PLOS ONE Anton BP, Chang YC, Brown P, Choi HP, Faller LL, Guleria J, Hu Z, Klitgord N, Levy-Moonshine A, Maksad A, Mazumdar V, McGettrick M, Osmani L,Pokrzywa R, Rachlin J, Swaminathan R, Allen B, Housman G, Monahan C, Rochussen K, Tao K, Bhagwat AS, Brenner SE, Columbus L, de Crécy-Lagard V, Ferguson D, Fomenkov A, Gadda G, Morgan RD, Osterman AL, Rodionov DA, Rodionova IA, Rudd KE, Söll D, Spain J, Xu SY, Bateman A,Blumenthal RM, Bollinger JM, Chang WS, Ferrer M, Friedberg I, Galperin MY, Gobeill J, Haft D, Hunt J, Karp P, Klimke W, Krebs C, Macelis D, Madupu R, Martin MJ, Miller JH, O'Donovan C, Palsson B, Ruch P, Setterdahl A, Sutton G, Tate J, Yakunin A, Tchigvintsev D, Plata G, Hu J, Greiner R, Horn D,Sjölander K, Salzberg SL, Vitkup D, Letovsky S, Segrè D, DeLisi C, Roberts RJ, Steffen M, Kasif S.
2004 The first amendment and scientific freedom in the era of bioterrorism. J.Biolaw and Business Anton, B.P.
2013 Vectors Brenner's Encyclopedia of Genetics Anton, B.P.
2016 Complete Genome Sequence of NEB 5-alpha, a Derivative of Escherichia coli K-12 DH5 alpha. Genome Announc. Anton, B.P. and Raleigh, E.A.
2016 Complete Genome Sequence of the Engineered Escherichia coli SHuffle Strains and Their Wild-Type Parents Genome Announc. Anton, B.P., Fomenkov, A., Raleigh, E.A. and Berkmen, M.
2016 Comparative Methylome Analysis of the Occasional Ruminant Respiratory Pathogen Bibersteinia trehalosi. PLoS One Anton, B.P., Harhay, G.P., Smith, T.P., Blom, J. and Roberts, R.J.
1997 Cloning and characterization of the BglII restriction-modification system reveals a possible evolutionary footprint. Gene Anton, B.P., Heiter, D.F., Benner, J.S., Hess, E.J., Greenough, L., Moran, L.S., Slatko, B.E., and Brooks, J.E.
2015 Complete Genome Sequence of ER2796, a DNA Methyltransferase-Deficient Strain of Escherichia coli K-12 PLoS One Anton, B.P., Mongodin, E.F., Agrawal, S., Fomenkov, A., Byrd, D.R., Roberts, R.J. and Raleigh, E.A.
2010 Functional characterization of the YmcB and YqeV tRNA methylthiotransferases of Bacillus subtilis. Nucl.Acids.Res. Anton, B.P., Russell, S.P., Vertrees, J., Kasif, S., Raleigh, E.A., Limbach, P.A.and Roberts, R.J.
2008 RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli. Proc Natl Acad Sci. Anton, B.P., Saleh, L., Benner, J.S., Raleigh, E.A., Kasif, S.and Roberts, R.J.
2004 Transposon-mediated linker insertion scanning mutagenesis of the Escherichia coli McrA endonuclease. J.Bacteriol. Anton, B.P.and Raleigh, E.A.
2007 Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo J. Biol. Chem. Aoki, K., Perlman, M., Lim, J.M., Cantu, R., Wells, L., Tiemeyer, M.
2015 Development of a Rapid, Simple Method for Detecting Naegleria fowleri Visually in Water Samples by Loop-Mediated Isothermal Amplification (LAMP). PLoS One Aongart Mahittikorn, Hirotake Mori, Supaluk Popruk, Amonrattana Roobthaisong, Chantira Sutthikornchai, Khuanchai Koompapong, Sukhontha Siri, Yaowalark Sukthana, Duangporn Nacapunchai Isothermal Amplification
2014 Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes J Cell Sci Arakel EC, Brandenburg S, Uchida K, Zhang H, Lin YW, Kohl T, Schrul B, Sulkin MS, Efimov IR, Nichols CG, Lehnart SE, Schwappach B Glycobiology
2016 Adaptive genetic variation distinguishes Chilean blue mussels (Mytilus chilensis) from different marine environments. Ecol Evol. Araneda C, Larraín MA, Hecht B, Narum S.
1987 Brugia malayi: recombinant antigens expressed by genomic DNA clones. Exp.Parasitol. Arasu , P., Philipp, M., and Perler, F.
1987 Genomic Cloning of Recombinant Antigens Detected by Antiserum Against Infective Larvae of Brugia Malayi. Molecular Paradigms for Eradicating Helminthic Parasites Arasu, P., and Perler, F.B.
1989 Human T-cell stimulation, molecular characterization and in situ mRNA localization of a Brugia malayi recombinant antigen. Mol.Biochem.Parasitol. Arasu, P., Nutman, T.B., Steel, C., Mulligan, M.M., Abraham, D., Tuan, R.S., and Perler, F.B.
2010 In vitro genetic reconstruction of bacterial transcription initiation by coupled synthesis and detection of RNA polymerase holoenzyme Nucleic Acids Res. Asahara, H. and Chong, S.
2010 In vitro genetic reconstruction of bacterial transcription initiation by coupled synthesis and detection of RNA polymerase holoenzyme. Nucl.Acids.Res. Asahara, H.and Chong, S.
2015 Targeted Glycoengineering Extends the Protein N-glycosylation Pathway in the Silkworm Silk Gland Sci Rep Asazuma HM., Sohn BH., Kim Y.S., Kuo CW., Khoo KH., Kucharski CA., Fraser MJ., Jarvis DL.
2008 Bioluminescent virion shells; new tools for quantitation of AAV vector dynamics in cells and live animals Gene Ther. Asokan, A., Johnson, J.S., Li, C., Samulski, R.J.
1991 Cross-linking of a monoclonal antibody-antigen complex enables detection of parasite antigen in immunoblots and in an expression library. Mol.Biochem.Parasitol. Awobuluyi, M., Mania, C.V., and Carlow, C.K.S.
2008 DNA distortion and specificity in a sequence-specific endonuclease. J.Mol.Biol. Babic, A.C., Little, E.J., Manohar, V.M., Bitinaite, J., Horton, N.C.
2008 Construction of intein mediated hGMCSF expression vector and its prufication in Pichia pastoris Protein Exp. Purif. Babu, S.K., et. al.
2001 Recombinant human DNA (cytosine-5) methyltransferase.III.Allosteric control, reaction order, and influence of plasmid topology and triplet repeat length on methylation of the fragile X CGGCCG sequence. J.Biol.Chem. Bacolla, A., Pradhan, S., Larson, J.E., Roberts, R.J.and Wells, R.D.
1999 Human DNA (Cytosine-5) Methyltransferase.II.steady-state kinetics reveal allostericactivation by methylated DNA. J.Biol.Chem. Bacolla, A., Pradhan, S., Roberts, R.J.and Wells, R.D.
2007 A highly sensitive assay for monitoring the secretory pathway and ER stress  PLoS One Badr, C.E., Hewett, J.W., Breakefield, X.O. and Tannous, B.A.
2007 A highly sensitive assay for monitoring the secretory pathway and ER stress. PLoS One Badr. C.E., Hewett, J.W., Breakefield, X.Q and Tannous, B.A.
1994 Ligand-induced conformational states of the cytosine-specific DNA methyltransferase M.HgaI-2. J.Mol.Biol. Baldwin, G.S., Kelly, S.M., Price, N.C., Wilson, G.G., Connolly, B.A., Artymiuk, P.J., and Hornby, D.P.
1994 Expression, purification, and crystallization of restriction endonuclease PvuII with DNA containing its recognition site Proteins Balendiran, K., Bonventre, J., Knott, R., Jack, W., Benner, J., Schildkraut, I., and Anderson, J.E.
2010 Peptides from phage display library modulate gene expression in mesenchymal cells and potentiate osteogenesis in unicortical bone defects Vis. Exp. Balian, G. et al. Phage Display
2008 Caged substrates for protein labeling and immobilization Chembiochem Banala J. et al.
2008 Caged substrates for protein labeling and immobilization Chembiochem Banala J. et al.
1999 Wolbachia genomes and the many faces of symbiosis. Parasitology Today Bandi, C., Slatko, B.and O'Neill, S.L.
2009 Indo-1 Derivatives for local calcium sensing JACS Chemical Biology Bannwarth et. al.
2007 Expression and purification of BmrI restriction endonuclease and its N-terminal cleavage domain variants. Protein Expr.Purif. Bao, Y., Higgins, L., Zhang, P., Chan, S-H., Laget, S., Sweeney, S., Lunnen, K.and Xu, S-Y.
2008 Expression and purification of BmrI restriction endonucleases and its N-terminal cleavage domain variants Bao, Y., Higgins, Zhang, P., Chan, S.H., Lagaet, S., Sweeney, S., Lunnen, K., Xu, S.Y.
1992 The corrected nucleotide sequences of the TaqI restriction and modification enzymes reveal a thirteen-codon overlap. Gene Barany, F., Slatko, B., Danzitz, M., Cowburn, D., Schildkraut, I., and Wilson, G.G.
1999 Plasmodium vivax, P.cynomolgi, and P.knowlesi: Identification of Homologue Proteins Associated with the Surface of Merozoites. Exp.Parasitol. Barnwell, J.W., Galinski, M.R., DeSimone, S.G., Perler, F.and Ingravallo, P.
1989 Site-directed mutagenesis of the EcoRV methylase for the study of the functional role of the conserved sequences in N6-adenine methylases J. Cell Biochem Barshevsky,T. and Benner J.S.
1988 Cloning of the HhaI and HinPI restriction-modification systems. Gene Barsomian, J.M., Card, C.O., and Wilson, G.G.
2008 Crucial role of aspartic acid at position 265 in the CH2 domain for murine IgG2a and IgG2b Fc-associated effector functions J Immunol. Baudino L, Shinohara Y, Nimmerjahn F, Furukawa J, Nakata M, Martínez-Soria E, Petry F, Ravetch JV, Nishimura S, Izui S.
2016 The Inhibitory Effect of Non-Substrate and Substrate DNA on the Ligation and Self-Adenylylation Reactions Catalyzed by T4 DNA Ligase. PLoS One Bauer, R.J., Evans, T.C. Jr. and Lohman, G.J.
2017 Rapid Time Scale Analysis of T4 DNA Ligase–DNA Binding. Biochemistry Bauer, R.J., Jurkiw, T.J., Evans, T.C. Jr. and Lohman, G.J.
2014 Biomimetic Magnetite Formation From Biocombinatorial Approaches to Mineralization Effects Langmuir Baumgartner J, Carillo MA, Eckes KM, Werner P, Faivre D. Phage Display
2015 Terminal Mannose Residues in Seminal Plasma Glycoproteins of Infertile Men Compared to Fertile Donors Int J Mol Sci Beata O., Jarząb A., Kratz E., Zimmer M., Gamian A., Ferens-Sieczkowska M.
2013 Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury. Clin. Chem. Beck J, Bierau S, Balzer S, Andag R, Kanzow P, Schmitz J, Gaedcke J, Moerer O, Slotta JE, Walson P, Kollmar O, Oellerich M, Schütz E.
2015 Multivalent site-specific phage modification enhances the binding affinity of receptor ligands Bioconjug Chem Beech, J., Saleh, L., Frentzel, J., Figler, H., Correa, I.R. Jr., Baker, B., Ramspacher, C., Marshall, M., Dasa, S., Linden, J., Noren, C.J. and Kelly, K.A.
1997 Homing endonucleases: keeping the house in order. Nucl.Acids Res. Belfort, M., and Roberts, R.J.
2005 Cleavage of individual DNA strands by the different subunits of the heterodimeric restriction endonuclease BbvCI. J.Mol.Biol. Bellamy, S.R.W., Milsom, S.E., Scott, D.J., Daniels, L.E., Wilson, G.G.and Halford, S.E.
2013 Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation eLife Benjamin A Smith, Shae B Padrick, Lynda K Doolittle, Karen Daugherty-Clarke, Ivan R Corrêa Jr, Ming-Qun Xu, Bruce L Goode3, Michael K Rosen, Jeff Gelles
2012 Production of disulfide-bonded proteins in Escherichia coli Protein Expression and Purification Berkmen, M.
2012 Oxidative folding of proteins in Escherichia coli BioProcess International Berkmen, M.
2012 Oxidative folding of proteins in Escherichia coli BioPharm International Berkmen, M.
Production of disulfide-bonded proteins in Escherichia coli Berkmen, M.
2009 EcR-B1 and Usp nuclear hormone receptors regulate expression of the VM32E eggshell gene during Drosophila  oogenesis. Dev.Biol. Bernardi, F., Romani, P., Tzertzinis, G., Gargiulo, G.and Cavaliere V.
2006 Evidence supporting a cisi-enedio-based mechanism for Pyrococcus furiousus phophoglucose isomerase. J Mol Biol. Berrisford, J.M., Hounslow, A.M., Akerboom, J., Hagen, W.R., Brouns, S.J., van der Oost, J., Murray, I.A., Michael Blackburn, G., Waltho, J.P., Rice, D.W.and Baker, P.J.