We believe that basic research and the cultivation of scientific knowledge is critical for us to stay connected with our customers and to drive scientific breakthroughs. At NEB, over 30 labs participate in research projects, which are aided by post-doctoral fellows and students in Masters and Ph.D. programs. NEB researchers have authored or co-authored over 1,000 publications (as of 1/17) many of which are in peer-reviewed journals. Further, NEB products have been used successfully in numerous publications by scientists throughout the world.

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Year Title Journal Authors Application(s)
2016 Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications. Nucleic Acids Res. Hashimoto, H., Zhang, X., Zheng, Y., Wilson, G.G. and Cheng, X.
2016 Complete genome and methylome sequences of two Salmonella Genome Announcements Yao, K., Muruvanda, T., Roberts, R.J., Payne, J., Allard, M.W., Hoffmann, M.
2016 Heme acquisition in the parasitic filarial nematode Brugia malayi. FASEB J. Luck, A.N., Yuan, X., Voronin, D., Slatko, B.E., Hamza, I. and Foster, J.M.
2016 Metabolic Incorporation of Azide Functionality into Cellular RNA. Chembiochem Nainar, S., Beasley, S., Fazio, M., Kubota, M., Dai, N., Correa, I.R. Jr. and Spitale, R.C.
2016 Association of 5-hydroxymethylation and 5-methylation of DNA cytosine with tissue-specific gene expression Epigenetics. Ponnaluri, V.K., Ehrlich, K.C., Zhang, G., Lacey, M., Johnston, D., Pradhan, S. and Ehrlich, M.
2016 Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Nucleic Acids Res. Esteve, P.O., Zhang, G., Ponnaluri, V.K., Deepti, K., Chin, H.G., Dai, N., Saqum, C., Black, K., Correa, I.R. Jr., Bedford, M.T., Cheng, X. and Pradhan, S.
2016 A Genetic Map for the Only Self-Fertilizing Vertebrate. G3 (Bethesda) Kanamori A, Sugita Y, Yuasa Y, Suzuki T, Kawamura K, Uno Y, Kamimura K, Matsuda Y, Wilson CA, Amores A, Postlethwait JH, Suga K, Sakakura Y.
2016 Characterizing Two Inter-specific Bin Maps for the Exploration of the QTLs/Genes that Confer Three Soybean Evolutionary Traits. Front Plant Sci. Wang W, Liu M, Wang Y, Li X, Cheng S, Shu L, Yu Z, Kong J, Zhao T, Gai J.
2016 Adaptive genetic variation distinguishes Chilean blue mussels (Mytilus chilensis) from different marine environments. Ecol Evol. Araneda C, Larraín MA, Hecht B, Narum S.
2016 RAD mapping reveals an evolving polymorphic and fuzzy boundary of a plant pseudoautosomal region Mol Ecol. Qiu S, Bergero R, Guirao-Rico S, Campos JL, Cezard T, Gharbi K, Charlesworth D.
2016 RAD-seq data point to a northern origin of the arctic-alpine genus Cassiope (Ericaceae). Mol Phylogenet Evol. Hou Y, Nowak MD, Mirré V, Bjorå CS, Brochmann C, Popp M.
2016 RAD-seq derived genome-wide nuclear markers resolve the phylogeny of tunas. Mol Phylogenet Evol. Díaz-Arce N, Arrizabalaga H, Murua H, Irigoien X, Rodríguez-Ezpeleta N.
2016 Mapping the sex determination locus in the hāpuku (Polyprion oxygeneios) using ddRAD sequencing. BMC Genomics. Brown JK, Taggart JB, Bekaert M, Wehner S, Palaiokostas C, Setiawan AN, Symonds JE, Penman DJ.
2016 Plasmid-based one-pot saturation mutagenesis Nature Methods Wrenbeck E.E., Klesmith J.R., Stapleton J.A., Adeniran A., Tyo K.E., & Whitehead T.A
2016 RAD mapping reveals an evolving, polymorphic and fuzzy boundary of a plant pseudoautosomal region. Mol Ecol. Qiu S, Bergero R, Guirao-Rico S, Campos JL, Cezard T, Gharbi K, Charlesworth D.
2016 Simple and Highly Sensitive Molecular Diagnosis of Zika Virus by Lateral Flow Assays. Anal Chem. Lee D, Shin Y, Chung S, Hwang KS, Yoon DS, Lee JH
2016 Training the Next Generation of Biomedical Investigators in Glycosciences. J. Clin. Invest. Agre, P., Bertozzi, C., Bissell, M., Campbell, K., Cummings, R., Desai, U., Estes, M., Flotte, T., Fogleman, G.,Gage, F., Ginsburg, D., Gordon, J.I., Hart, G., Hascall, V., Kiessling, L., Kornfeld, S., Lowe, J., Magnani, J., Mahal, L.K., Medzhitov, R., Roberts, R., Sackstein, R., Sarkar, R., Schnaar, R., Schwartz, N., Varki, A., Walt, D., Weissman, I.
2016 Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression. Oncotarget Chin, H.G., Ponnaluri, C., Zhang, G., Esteve, P., Schaus, S.E., Hansen, U. and Pradhan, S.
2016 Incipient sympatric speciation in Midas cichlid fish from the youngest and one of the smallest crater lakes in Nicaragua due to differential use of the benthic and limnetic habitats? Ecol Evol. Kautt AF, Machado-Schiaffino G, Torres-Dowdall J, Meyer A.
2016 Construction of High-Density Linkage Maps of Populus deltoides × P. simonii Using Restriction-Site Associated DNA Sequencing. PLoS One. Tong C, Li H, Wang Y, Li X, Ou J, Wang D, Xu H, Ma C, Lang X, Liu G, Zhang B, Shi J.
2016 De novo SNP discovery and genetic linkage mapping in poplar using restriction site associated DNA and whole-genome sequencing technologies. BMC Genomics Mousavi M, Tong C, Liu F, Tao S, Wu J, Li H, Shi J.
2016 Development of a RAD-Seq Based DNA Polymorphism Identification Software, AgroMarker Finder, and Its Application in Rice Marker-Assisted Breeding. PLoS One. Fan W, Zong J, Luo Z, Chen M, Zhao X, Zhang D, Qi Y, Yuan Z.
2016 COMBREX-DB: An experiment centered database of protein function: knowledge, predictions and knowledge gaps. Nucl. Acids Res. Chang, Y.-C., Hu, Z., Rachlin, J., Anton, B.P., Kasif, S., Roberts, R.J. and Steffen, M.
2016 Complete genome sequence of Brevibacterium linens SMQ-1335. Genome Announcements De Melo, A., Labrie, S., Dumaresq, J., Roberts, R., Tremblay, D. and Moineau, S.
2016 Complete Genome Sequence of NEB 5-alpha, a Derivative of Escherichia coli K-12 DH5 alpha. Genome Announc. Anton, B.P. and Raleigh, E.A.
2016 Genetic Divergence between Camellia sinensis and Its Wild Relatives Revealed via Genome-Wide SNPs from RAD Sequencing. PLoS One. Yang H, Wei CL, Liu HW, Wu JL, Li ZG, Zhang L, Jian JB, Li YY, Tai YL, Zhang J, Zhang ZZ, Jiang CJ, Xia T, Wan XC.
2016 Global repositioning of transcription start sites in a plant-fermenting bacterium. Nat Commun Boutard, M., Ettwiller, L., Cerisy, T., Alberti, A., Labadie, K., Salanoubat, M., Schildkraut, I. and Tolonen, A.C.
2016 Hydroxymethyluracil modifications enhance the flexibility and hydrophilicity of double-stranded DNA. Nucleic acids research Carson, S., Wilson, J., Aksimentiev, A., Weigele, P. R., & Wanunu, M.
2016 Development of a universal and simplified ddRAD library preparation approach for SNP discovery and genotyping in angiosperm plants. Plant Methods. Yang GQ, Chen YM, Wang JP, Guo C, Zhao L, Wang XY, Guo Y, Li L, Li DZ, Guo ZH.
2016 DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A: T-rich target. Nucleic Acids Res. Shen, B.W., Heiter, D.F., Lunnen, K.D., Wilson, G.G. and Stoddard, B.L.
2016 Efficient In Situ Detection of mRNAs using the Chlorella virus DNA ligase for Padlock Probe Ligation RNA Schneider, N and Meier, M.
2016 Evaluation of a glycoengineered monoclonal antibody via LC-MS analysis in combination with multiple enzymatic digestion MAbs Liu, R., Giddens, J., McClung, C.M., Magnelli, P.E., Wang, L.X., Guthrie, E.P.
2016 Distributive processing by the Iron(II)/α-Ketogluterate-dependent catalytic domains of the TET enzymes in consistent with epigenetic roles for oxidized 5-methylcytosine bases J Am Chem Soc. Tamanaha, E., Guan, S., Marks, K., Saleh, L.
2016 High-temperature single-molecule kinetic analysis of thermophilic archaeal MCM helicases Nucleic Acids Res. Schermerhorn, K.M., Tanner, N., Kelman, Z. and Gardner, A.F.
2016 Adapting capillary gel electrophoresis as a sensitive, high-throughput method to accelerate characterization of nucleic acid metabolic enzymes Nucleic Acids Res. Greenough, L., Schermerhorn, K.M., Mazzola, L., Bybee, J., Rivizzigno, D., Cantin, E., Slatko, B.E., Gardner, A.F.
2016 Complete Genome Sequence of Escherichia coli ER1821R, a Laboratory K-12 Derivative Engineered To Be Deficient in All Methylcytosine and Methyladenine Restriction Systems Genome Announc. Jobling, M.G., Raleigh, E.A. and Frank, D.N.
2016 Comprehensive nucelosome mapping of the human genome in cancer progression Oncotarget Druliner, B.R., Vera, D., Johnson, R., Ruan, X., Apone, L.M., Dimalanta, E.T., Stewart, F.J., Boardman, L., Dennis, J.H.
2016 One-pot system for synthesis, assembly, and display of functional single-span membrane proteins on oil-water interfaces Proc. Natl Acad Sci USA Yunker, P.J., Asahara, H., Hung, K.C., Landry, C., Arriaga, L.R., Akartuna, I., Heyman, J., Chong, S., Weitz, D.A.
2016 Structural basis for human PRDM9 action at recombination hot spots Genes Dev Patel, A., Horton, J.R., Wilson, G.G., Zhang, X. and Cheng, X.
2016 The endoplasmic reticulum: structure, function and response to cellular signaling Cell Mol Life Sci. Schwarz, D.S., Blower, M.D.
2016 Phenotypic and molecular analysis of the effect of 20 hydroxyecdysone on the human filarial parasite Brugia malayi Int J Parasitol Mhashilkar, A.S., Adapa, S.R., Jiang, R.H., Williams, S.A., Zaky, W., Slatko, B.E., Luck, A.N., Moorhead, A.R. and Unnasch, T.R.
2016 Perpetuating the homing endonuclease life cycle: identification of mutations that modulate and change I-TevI cleavage preference Nucleic Acids Res. Roy, A.C., Wilson, G.G. and Edgell, D.R.
2016 Sequential formation of two branched intermediates during protein splicing of class three inteins Extremophiles Tori, K. and Perler, F.
2016 A microbiome DNA enrichment method for next-generation sequencing sample preparation Curr Prot Mol Biol. Yigit, E., Feehery, G.R., Langhorst, B.W., Stewart, F.J., Dimalanta, E.T., Pradhan, S., Slako, B., Gardner, A.F., McFarland, J., Sumner, C., Davis, T.B.
2016 A high-throughput assay for the comprehensive profiling of DNA ligase fidelity Nucleic Acids Res. Lohman, G.J., Bauer, R.J., Nichols, N.M., Mazzola, L., Bybee, J., Rivizzigno, D., Cantin, E., Evans, T.C., Jr.
2015 A simple bridging flocculation assay for rapid, sensitive and stringent detection of gene specific DNA methylation Sci Rep Wee E., Ngo T., Trau M. Epigenetics,DNA Enrichment
2015 A Proline-Rich Domain in the Genotype 4 Hepatitis E Virus ORF3 PLoS One Wang H., Fangxiao J., Liang H., Gu H.
2015 A high-throughput assay for the comprehensive profiling of DNA ligase fidelity Nucleic Acids Res Lohman GJ, Bauer RJ, Nichols NM, Mazzola L, Bybee J, Rivizzigno D, Cantin E, Evans TC Jr.
2015 A New Approach to Produce HIV-1 Envelope Trimers: BOTH CLEAVAGE AND PROPER GLYCOSYLATION ARE ESSENTIAL TO GENERATE AUTHENTIC TRIMERS. J Biol Chem AlSalmi W., Mahalingam M., Ananthaswamy N., Hamlin C., Flores D., Gao G., Rao V.B.
2015 A database for DNA restriction and modification: enzymes, genes and genomes. Nucleic Acids Research Roberts, R.J., Vincze, T., Posfai, J., Macelis, D.