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Welcome to NEB's Science Blog, NEBinspired® -
Sharing our passion for science, one story at a time

NEBinspired is a science blog designed to share inspirational stories about trends in the life sciences, lab tips to help you save time, and life lessons to reflect on. Browse our collection of science stories, or filter to find a topic that you are passionate about. From groundbreaking discoveries to sustainable lab techniques and helpful online tools that will aid your experimental design, we have something for everyone. And if you can’t find what you’re looking for, not to worry – simply send us a message about topics you would like to see covered.

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E5hmC-seq™ is a Sequencing Method for Direct 5hmC Detection that Leverages Improved Data Quality from Enzymatic Conversion

Posted on Friday, March 1, 2024 By Nicole Kelesoglu

Learn about a new method to directly detect 5hmC at single-base resolution in this interview with NEB scientist, Dan Evanich, Ph.D..

Topic: Tips for the lab

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Four alternative and powerful cloning applications of NEBuilder® HiFi DNA assembly

Posted on Monday, January 8, 2024 By Joanne Gibson, Ph.D., Illustrations by Tasha José

Explore the versatility of NEBuilder HiFi DNA Assembly in our latest blog. Expand your toolkit with four alternative applications for DNA manipulation.

Topic: Tips for the lab, What is Trending in Science

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Numerous colorful arch-shaped building blocks

The Vital Role of Restriction Enzymes in Molecular Cloning and DNA Assembly 

Posted on Friday, December 8, 2023 By Lydia Morrison, M.S.

The functionality of restriction enzymes extends beyond bacterial defense mechanisms, with pivotal applications in genetic engineering processes.

Topic: Tips for the lab, What is Trending in Science

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NEBinspired blog thumbnail stylized molecular rendering of enzyme bound to DNA

Overcoming challenges in FFPE DNA library prep

Posted on Wednesday, October 25, 2023 By Joanne Gibson, Ph.D.

Formalin-fixed paraffin-embedded (FFPE) samples hold invaluable genetic insights, yet library preparation is notoriously challenging. FFPE preservation processes damage DNA, resulting in low yields, non-uniform ends, and other issues. Our advanced enzymatic solutions tackle these challenges, enabling the full utilization of FFPE samples for genetic analysis.

Topic: Tips for the lab, What is Trending in Science

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photograph of a blue gloved hand holding a slide with a tissue sample and an out of focus microscope in the background

Superior error detection using Authenticase® enhances assembled gene synthesis

Posted on Tuesday, September 5, 2023 By Joanne Gibson, Ph.D.

Gene synthesis often grapples with residual errors in DNA fragments, making traditional error detection methods labor-intensive and expensive. Authenticase® employs structure-specific enzymes for proficient error correction. Paired with Q5® High-Fidelity DNA Polymerase, it enhances DNA quality and simplifies the synthesis workflow.

Topic: What is Trending in Science, Tips for the lab

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