HomeFAQsIs NEBNext UltraShear™ the same as NEBNext® Ultra™ II FS or NEBNext dsDNA Fragmentase®?
FAQ: Is NEBNext UltraShear™ the same as NEBNext® Ultra™ II FS or NEBNext dsDNA Fragmentase®?
No. These enzymatic fragmentation reagents do not contain the same enzymes. NEBNext UltraShear has been designed for challenging samples including FFPE DNA and for methylome analysis. NEBNext Ultra II FS is our recommendation for standard DNA library prep for Illumina® sequencing, and it has a more streamlined workflow. NEBNext dsDNA Fragmentase is our legacy product for enzyme-based DNA fragmentation.
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