FAQ: How is Thermolabile Proteinase K different from Proteinase K, Molecular Biology Grade?

Thermolabile Proteinase K is an engineered and recombinantly expressed variant of Proteinase K, Molecular Biology Grade (wild type). The cleavage patterns of both enzymes are the same: they prefer aromatic and aliphatic amino acids. Thermolabile Proteinase K can be heat inactivated by incubating at 55°C for 10 minutes; and it retains optimal activity between 20–40°C.