FAQ: Is PspOMI activity sensitive to dam, dcm or mammalian CpG methylation?

Yes. Cleavage of mammalian genomic DNA by PspOMI is blocked by CpG methylation. Cleavage is also impaired by some combinations of overlapping dcm methylation. For up-to-date information about methylation sensitivities, please visit Dam-Dcm and CpG Methylation or REBASE.

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