Control DNA for Epigenetics

Techniques used for methylation detection and analysis require high quality control DNA for comparison to sample DNA. In vitro methylated DNA using a CpG methyltransferase gives us the opportunity to specifically generate positive control DNA for methylation studies. Alternatively, mammalian DNA can also be used for methylation studies like bisulfite conversion, methyl sensitive PCR (MSP), methyl-DNA immunoprecipitation (Me-DIP) or by methyl-CpG binding domain (MBD)-based capture techniques.

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