FAQ: What are the differences between Mismatch Endonuclease I (NEB #M0678) and Authenticase (NEB #M0689)?

Mismatch Endonuclease I only cleaves the following DNA mismatches: G/G, G/T and T/T.  Authenticase will cleave all single base mismatches (except for G/A) and all 2+ base pair DNA mismatches and indels (insertion and/or deletion).