Deliberate introduction of exogenous RNA into cells has numerous experimental applications. Cytosolic delivery of RNA into mammalian cells is typically accomplished using electroporation or forming complexes of RNA with chemical compounds that facilitate their cellular uptake by (1). Transfection of short interfering RNA (siRNA) and long RNA has revolutionized the study of gene function.
- Warren, L., et al (2010) Cell Biology 7, 618-630. PMID: 20888316