Glycobiology_Ban

Glycoprotein Production in Various Expression Systems

There is a growing interest in producing recombinant glycoproteins. In addition to enabling the researcher to produce glycoproteins for functional studies, it also importantly allows the production of therapeutic glycoproteins such as immunoglobulins for the large and growing biopharmaceutical market. While most commonly used bacterial hosts do not modify the produced protein with glycans and so are not suitable for glycoprotein expression, many eukaryotic hosts have this capability. Several dedicated systems such as mammalian, insect, yeast and plant cells have been developed to express proteins, and each has their relative advantages and disadvantages (1).

References

  1. Betenbaugh M.J., et al (2004) Curr Opin Struct Biol. 14(5):601-6. PMID: 15465322

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