Cloning and Mapping

Synthetic Biology

Synthetic biology describes the use of chemically-synthesized nucleic acids to create life. The first successful instance of a completely synthetic organism was developed by Daniel Gibson in 2010 (1). Synthetic biologists continue to pursue the creation of a minimal organism, using only the bare minimum of components to maintain life.


  1. Gibson, D.G., et al., Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome, Science 2 July 2010: Vol. 329 no. 5987 pp. 52-56. PMID: 20488990

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Protocols for Synthetic Biology

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Overview of Gibson Assembly®

Gibson Assembly® (NEB #E2611) was developed by Dr. Daniel Gibson and his colleagues at the J. Craig Venter Institute and licensed to NEB by Synthetic Genomics, Inc. It allows for successful assembly of multiple DNA fragments, regardless of fragment length or end compatibility. It has been rapidly adopted by the synthetic biology community due to its ease-of-use, flexibility and suitability for large DNA constructs.
Gibston Assembly® is a registered trademark of Synthetic Genomics, Inc.

Overview of BioBrick® Assembly Kit

The BioBrick™ Assembly Kit (NEB #E0546) provides a streamlined method for assembly of BioBrick parts into multi-component genetic systems. BioBrick parts are DNA sequences that encode a defined biological function and can be readily assembled with any other BioBrick part. The process for assembling any two BioBrick parts is identical and results in a new composite BioBrick part.
The BioBrick Assembly Kit was developed in partnership with Ginkgo BioWorks.
BioBrick™ is a trademark of The BioBricks Foundation.