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We believe that basic research and the cultivation of scientific knowledge is critical for us to stay connected with our customers and to drive scientific breakthroughs. At NEB, over 30 labs participate in research projects, which are aided by post-doctoral fellows and students in Masters and Ph.D. programs. NEB researchers have authored or co-authored over 1,200 publications (as of 1/19) many of which are in peer-reviewed journals. Further, NEB products have been used successfully in numerous publications by scientists throughout the world.

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Year Title Journal Authors Application(s)
2014 Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals a rational approach to the discovery of anthelmintic drugs <em>PLoS Pathogens</em> Farelli, J.D., Galvin, B.D., Li, Z., Liu, C., Aono, M., Garland, M., Hallett, O.E., Causey, T.B., Ali-Reynolds, A., Carlow, C.K.S., Dunaway-Mariano, D. and Allen, K.N.
2019 Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI Nucl. Acids Res. Shen, B.W., Doyle, L., Bradley, P., Heiter, D.F., Lunnen, K.D., Wilson, G.G., Stoddard, B.L.
2012 Structure-function analysis of Methanobacterium thermoautotrophicum RNA ligase - engineering a thermostable ATP independent enzyme BMC Mol Biol. Zhelkovsky, A.M. and McReynolds, L.A.
1998 Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nature Struct.Biol. O'Gara, M., Horton, J.R., Roberts, R.J.and Cheng, X.
1999 Structures of a Binary Complex of HhaI Methyltransferase with S-adenosyl-L-methionine Formed in the Presence of a Short Non-specific DNA Oligonucleotide. J.Mol.Biol. O'Gara, M., Zhang, X., Roberts, R.J.and Cheng, X.
2008 Structures of the rare-cutting restriction endonuclease NotI reveal a unique metal binding fold involved in DNA binding. Structure Lambert, A.R., Sussman, D., Shen, b., Maunus, R., Nix, J., Samuelson, J., Xu, S.Y.and Stoddard, B.L.
2012 Stucture and cleavage activity of the tetrameric MspJI DNA modification-dependent restriction endonuclease. Nucleic Acids Research Horton, J.R., Mabuchi, M., Cohen-Karni, D., Zhang, X., Griggs, R., Samaranayake, M., Roberts, R.J., Zheng, Y. and Cheng, X.
2003 Study of protein splicing and intein-mediated peptide bond cleavage under high-cell-density conditions. Biotechnol.Prog. Sharma, S., Zhang, A., Wang, H., Harcum, S.W.and Chong S.
1997 Substrate DNA and cofactor regulate the activities of a multi-functional restriction-modification enzyme, Bcgl. Nucl.Acids Res. Kong, H., and Smith, C.L.
2012 Substrate cooperativity in marine luciferases PLoS One Tzertzinis, G., Schildkraut, E., and Schildkraut, I.