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We believe that basic research and the cultivation of scientific knowledge is critical for us to stay connected with our customers and to drive scientific breakthroughs. At NEB, over 30 labs participate in research projects, which are aided by post-doctoral fellows and students in Masters and Ph.D. programs. NEB researchers have authored or co-authored over 1,200 publications (as of 1/19) many of which are in peer-reviewed journals. Further, NEB products have been used successfully in numerous publications by scientists throughout the world.

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Year Title Journal Authors Application(s)
2000 Structure and function of the mouse DNA methyltransferase Gene, DNMT1 shows a tripartite structure. J Mol Biol Margot, J.B., Aguirre-Arteta, A.M., DiGiacco, B.V., Pradhan, S., Roberts, R.J., Cardoso, M.C.and Leonhardt, H.
2014 Structure and mutagenesis of the DNA modification-dependent restriction endonuclease AspBHI Sci Rep Horton JR, Nugent RL, Li A, Mabuchi MY, Fomenkov A, Cohen-Karni D, Griggs RM, Zhang X, Wilson GG, Zheng Y, Xu SY, Cheng X
2014 Structure of 5-hydroxymethylcytosine-specific restriction enzyme AbaSI in complex with DNA Nucleic Acids Res Horton JR, Borgaro JG, Griggs RM, Quimby A, Guan S, Zhang X, Wilson GG, Zheng Y, Zhu Z, Cheng X
1995 Structure of BamHI endonuclease bound to DNA: partial folding and unfolding on DNA binding. Science Newman, M., Strzelecka, T., Dorner, L.F., Schildkraut, I., and Aggarwal, A.K.
1998 Structure of FokI has Implications for DNA Cleavage. Proc Natl Acad Sci U S A Wah, D.A., Bitinaite, J., Schildkraut, I., Aggarwal, A.K.
2020 Structure of HhaI endonuclease with cognate DNA at an atomic resolution of 1.0 A Nucleic Acids Res Horton, J.R., Yang, J., Zhang, X., Petronzio, T., Fomenkov, A., Wilson, G.G., Roberts, R.J., DasSarma, S
2005 Structure of HinP1I endonuclease reveals a striking similarity to the monomeric restriction enzyme MspI. Nucleic Acids Res Yang, Z., Horton, J.R., Maunus, R., Wilson, G.G., Roberts, R.R.and Cheng, X.
2015 Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA Nucleic Acids Res Hashimoto H et al
2015 Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA. Nucleic Acids Res Hashimoto H, Pais JE, Dai N, Corrêa IR Jr, Zhang X, Zheng Y, Cheng X.
1994 Structure of PvuII endonuclease with cognate DNA. EMBO J Cheng, X., Balendiran, K., Schildkraut, I., and Anderson, J.E.