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We believe that basic research and the cultivation of scientific knowledge is critical for us to stay connected with our customers and to drive scientific breakthroughs. At NEB, over 30 labs participate in research projects, which are aided by post-doctoral fellows and students in Masters and Ph.D. programs. NEB researchers have authored or co-authored over 1,000 publications (as of 1/17) many of which are in peer-reviewed journals. Further, NEB products have been used successfully in numerous publications by scientists throughout the world.

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Year Title Journal Authors Application(s)
2009 "Adenosine Triphosphate Stimulates Aquifex aeolicus MutL Endonuclease Activity" PLoS ONE Mauris, J., & Evans, J
"Bacterial Systems" introduction of Membrane Proteins - Strategies for Expression and Isolation Samuelson, J.C.
2011 "First Generation" automated DNA sequencing technology Curr. Prot. Mol. Biol. Slatko, B.E., et al.
1999 "Protein Splicing" The Encyclopedia of Molecular Biology Perler, F.B., Xu, M.and Noren, C.J.
2011 "Recent Developments in Difficult Protein Expression: A Guide to E.coli strains, Promoters and Relevant Host Mutations" editors Tom C.Evans Jr.and Ming-Qun Xu, Humana Press Methods Mol.Biol. Samuelson, J.C.
2011 "The Molecular Biology, Immunology and chemotherapy of Wolbachia bacterial endosymbionts of filarial nematodes". Parasitic Nematodes: Molecular Biology, Biochemistry & Immunology (Kennedy, M.and Harnett, W., eds.) Foster, J.M., Hoerauf, A., Slatko, B.E.and Taylor, M.J.
2009 "Translational Recoding" The Wiley Encyclopedia of Chemical Biology, Tadhg P.Begley, Ed Osborne, E.M.and Noren, C.J.
2008 13C-sialic acid labeling of glycans on glycoproteins using ST6Gal-I J. Am. Chem Soc. Macnaughtan, M.A., Tian, F., Liu, S., Meng, L., Park, S., Azadi, P., Moremen, K.W., Prestegard, J.H.
2011 5-aza-2'-deoxycytidine and interleukin-1 cooperate to regulate matrix metalloproteinase-3 gene expression. Int.J.Cancer Couillard, J., Estève, P.O., Pradhan, S.and St-Pierre, Y.
2011 5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells Gen. Biol. Stroud, H., et al.
2011 6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1 Canc. Res.
2011 6-Thioguanine Reactivates Epigenetically Silenced Genes in Acute Lymphoblastic Leukemia Cells by Facilitating Proteasome-mediated Degradation of DNMT1 Cancer Res. Yuan, B., Zhang, J., Wang, H., Xiong, L., Cai, Q., Wang, T., Jacobsen, S., Pradhan, S. andd Wang, Y.
2004 A bacteriophage-based genetic system for selection of non-splicing inteins. Appl.Environ.Microbiol. Cann, I.K.O., Amaya, K.R., Southworth, M.W.and Perler, F.B.
2008 A cell-based luciferase assay amenable to high-throughput screening of inhibitors of arenavirus budding Virology Capul, A.A. and de la Torre, J.C.
2008 A cell-based luciferase assay amenable to high-throughput screening of inhibitors of arenavirus budding. Virology Capul, A.A. and de la Torre, J.C.
2009 A chemical genetic method for generating bivalent inhibitors of protein kinases J. Am. Chem. Soc. Hill Z. B.
2008 A codon-optimized luciferase from Caussia princeps facilitates the in vivo monitoring of gene expression in the model alga Chlamydomonas reinhardtii. Curr. Genet. Shao, N. and Bock, R.
2008 A codon-optimized luciferase from Gaussia princeps facilitates the in vivo monitoring of gene expression in the model alga Chlamydomonas reinhardtii Curr. Genet. Shao, N. and Bock, R.
2008 A comparative study of protein synthesis in in vitro systems: from the prokaryotic reconstituted to the eukaryotic extract-based. BMC Biotechnol. Hillebrecht, J.R.and Chong, S.
2007 A Concise Synthesis of the Pennsylvania green fluorophore and labeling of intracellular targets with O6-Benzylguanine Derivatives  Org. Lett. Mottram L. F. et al.
2014 A continuous-exchange cell-free protein synthesis system based on extracts from cultured insect cells PLoS One Stech M, Quast RB, Sachse R, Schulze C, Wüstenhagen DA, Kubick S Glycobiology
2007 A covalent chemical genotype-phenotype linkage for in vitro protein evolution ChemBioChem. Stein, V. et al.
2014 A crime against humanity. China Policy Review Roberts, R.J.
1996 A Cyclosporine A-Sensitive Small Molecular-Weight Cyclophilin Of Filarial Parasites. Mol.Biochem.Parasitol. Ma, D., Hong, X.Q., Raghavan, N., Scott, A.L., McCarthy, J.A., Nutman, T.B., Williams, S.A., and Carlow, C.K.S.
2015 A database for DNA restriction and modification: enzymes, genes and genomes. Nucleic Acids Research Roberts, R.J., Vincze, T., Posfai, J., Macelis, D.
2008 A designed protein for the specific and covalent heteroconjugation of biomolecules Bioconj. Chem. Chidley C. et al.
1987 A Developmentally regulated surface epitope expressed by the infective larva of Brugia malayi which is rapidly lost after infection. Molecular Paradigms for Eradicating Helmenthic Parasites Carlow, C.K.S., Perrone, J., Spielman, A., and Philipp, M.A.
2016 A DsbA-Deficient Periplasm Enables Functional Display of a Protein with Redox-Sensitive Folding on M13 Phage. Biochemistry Chen, M., Samuelson, J.C.
2003 A Dual Role for an Aspartic Acid in Glycosylasparaginase Autoproteolysis. Structure Qian, X., Guan, C.and Guo, H.-C.
2003 A fluorescence resonance energy transfer sensor for the beta-domain of metallothionein Proc. Natl. Acad. Sci. USA Hong, S.H., and Maret, W.
2010 A functional NR4A nuclear receptor DNA-binding domain is required for organ development in Caenorhabditis elegans. Genesis Heard, M., Maina, C.V., Morehead, B.E., Hoener, M.C., Nguyen, T.Q., Williams, C.C., Rowan, B.G.and Gissendanner, C.R.
2003 A fusion of disciplines: chemical approaches to exploit fusion proteins for functional genomics Chembiochem Johnsson N. and Johnsson K.
2003 A general method for the covalent labeling of fusion proteins with small molecules in vivo Nature Biotechnology Keppler A. et al.
2006 A genetic dissection of the LlaJI restriction cassette reveals insights on a novel bacteriophage resistance system. BMC Microbiol. O'Driscoll, J., Heiter, D.F., Wilson, G.G., Fitzgerald, G.F., Roberts, R.and van Sinderen, D.
2016 A Genetic Map for the Only Self-Fertilizing Vertebrate. G3 (Bethesda) Kanamori A, Sugita Y, Yuasa Y, Suzuki T, Kawamura K, Uno Y, Kamimura K, Matsuda Y, Wilson CA, Amores A, Postlethwait JH, Suga K, Sakakura Y.
2009 A genetically encoded bioluminescent indicator for the sodium channel activity in living cells J. Am. Chem. Soc. Kaihara, A., Sunami, A., Kurokawa, J., Furukawa, T.
2009 A genetically encoded bioluminescent indicator for the sodium channel activity in living cells J. Am. Chem. Soc. Kaihara, A., Sunami, A., Kurokawa, J. and Furukawa, T.
2004 A genome sequence survey of the filarial nematode Brugia malayi: repeats, gene discovery, and comparative genomics. Mol.Biochem.Parasitol. Whitton, C., Daub, J., Quail, M., Hall, N., Foster, J., Ware, J., Ganatra, M., Slatko, B., Barrell, B.and Blaxter, M.
2009 A genome-scale RNAi screen for Oct4 modulators defines a role of the Pafl complex for embryonic stem cell identity. Cell Stem Cell Ding, L., Paszkowski-Rogacz, M., Nitzsche, A., Slabicki, M.M., Heninger, A.K., de Vries, I., Kittler, R., Junqueira, M., Shevchenko, A., Schulz, H., Hubner, N., Doss, M.X., Sachinidis, A., Hescheler, J., Iacone, R., Anastassiadis, K., Stewart, A.F., Pisabarro, M.T., Caldarelli. A.. Poser, I., Theis, M. and Buchholz, F
2009 A genomescale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity Cell Stem Cell Ding, L., Paszkowski-Rogacz, M., Nitzsche, A., Slabicki, M.M., Heninger, A.K., de Vries, I., Kittler, R., Junqueira, M., Shevchenko, A., Schulz, H., Hubner, N., Doss, M.X., Sachinidis, A., Hescheler, J., Iacone, R., Anastassiadis, K., Stewart, A.F., Pisabarro, M.T., Caldarelli, A., Poser, I., Theis, M. and Buchholz, F.
2016 A high-throughput assay for the comprehensive profiling of DNA ligase fidelity Nucleic Acids Res. Lohman, G.J., Bauer, R.J., Nichols, N.M., Mazzola, L., Bybee, J., Rivizzigno, D., Cantin, E., Evans, T.C., Jr.
2015 A high-throughput assay for the comprehensive profiling of DNA ligase fidelity Nucleic Acids Res Lohman GJ, Bauer RJ, Nichols NM, Mazzola L, Bybee J, Rivizzigno D, Cantin E, Evans TC Jr.
1998 A highly conserved large molecular weight cyclophilin of filarial parasites. Exp.Parasitol. Hong, X., Ma, D., Page, A.P., Kumar, S.and Carlow, C.K.S.
2011 A highly controllable reconstituted cell-free system--a breakthrough in protein synthesis research Curr. Pharm. Biotechnol. Ohashi, H., Kanamori, T., Shimizu, Y. and Ueda, T.
2010 A highly controllable reconstituted cell-free system--a breakthrough in protein synthesis research Curr. Pharm. Biotechnol. Ohashi, H., Kanamori, T., Shimizu, Y. and Ueda, T.
2007 A highly sensitive assay for monitoring the secretory pathway and ER stress  PLoS One Badr, C.E., Hewett, J.W., Breakefield, X.O. and Tannous, B.A.
2007 A highly sensitive assay for monitoring the secretory pathway and ER stress. PLoS One Badr. C.E., Hewett, J.W., Breakefield, X.Q and Tannous, B.A.
2006 A highly sensitive protein-protein interaction assay based on Gaussia luciferase. Nat. Methods Remy. I. and Michnick, S.W.
2006 A highly sensitive protein-protein interaction assay based onGaussia luciferase Nat. Methods Remy, I. and Michnick, S.W.
2006 A highly sensitive protein-protein interaction assay based onGaussia luciferase Nat. Methods Remy, I. and Michnick, S.W.
2010 A human PMS2 homologue from Aquifex aeolicus stimulates an ATP-dependent DNA helicase. J Biol.Chem Mauris, J.and Evans, T.C., Jr.
1989 A l gt11 cDNA recombinant that encodes Dirofilaria immitis paramyosin. Mol.Biochem.Parasitol. Grandea, A.G.I., Le, T.K.T., Asikin, N., Davis, T.B., Philipp, M., Cohen, C., and McReynolds, L.A.
2015 A lipid switch unlocks Parkinson's disease-associated ATP13A2 Proc Natl Acad Sci U S A Holemans T., Sørensen DM., Veen S., Martin S., Hermans D., Kemmer GC., Haute C., Baekelandt V., Pomorski TG., Agostinis P., Wuytack F., Palmgren M., Eggermont J., Vangheluwe P.
2013 A membrane-bound NAC transcription factor, ANAC017, mediates mitochondrial retrograde signaling in Arabidopsis Plant Cell Ng S, Ivanova A, Duncan O, Law SR, Van Aken O, De Clercq I, Wang Y, Carrie C, Xu L, Kmiec B, Walker H, Van Breusegem F, Whelan J, Giraud E Gibson Assembly®
2015 A metagenomics and case-control study to identify viruses associated with bovine respiratory disease. J Virol Terry Fei Fan Ng, Nikola O Kondov, Xutao Deng, Alison Van Eenennaam, Holly L Neibergs, Eric Delwart cDNA Synthesis
2013 A Method for Selectively Enriching Microbial DNA from Contaminating Vertebrate Host DNA PLOS ONE George R. Feehery, Erbay Yigit, Samuel O. Oyola, Bradley W. Langhorst, Victor T. Schmidt, Fiona J. Stewart, Eileen T. Dimalanta, Linda A. Amaral-Zettler, Theodore Davis, Michael A. Quail, Sriharsa Pradhan
2011 A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nat Struct Mol Biol. Estève, P.O., Chang, Y., Samaranayake, M., Upadhyay, A.K., Horton, J.R., Feehery, G.R., Cheng, X.and Pradhan, S.
2016 A microbiome DNA enrichment method for next-generation sequencing sample preparation Curr Prot Mol Biol. Yigit, E., Feehery, G.R., Langhorst, B.W., Stewart, F.J., Dimalanta, E.T., Pradhan, S., Slako, B., Gardner, A.F., McFarland, J., Sumner, C., Davis, T.B.
1998 A Mitogen-activated Protein Kinase Pathway is Required for mu-Opioid Receptor Desensitization. J Biol Chem. Polakiewicz, R.D., Schieferl, S.M., Dorner, L.F., Kansra, V.and Comb, M.J.
2016 A mix-and-read drop-based in vitro two-hybrid method for screening high-affinity peptide binders. Sci Rep Cui, N., Zhang, H., Schneider, N., Tao, Y., Asahara, H., Sun, Z., Cai, Y., Koehler, S.A., de Greef, T.F., Abbaspourrad, A., Weitz, D.A. and Chong, S.
1995 A model for DNA binding and enzyme action derived from crystallographic studies of the TaqI N6-adenine-methyltransferase. Gene Schluckebier, G., Labahn, J., Granzin, J., Schildkraut, I., and Saenger, W.
2014 A Modified Janus Cassette (Sweet Janus) to Improve Allelic Replacement Efficiency by High-Stringency Negative Selection in Streptococcus pneumoniae PLoS One Li Y, Thompson CM, Lipsitch M Gibson Assembly®
2014 A Modular Plasmid Assembly Kit for Multigene Expression, Gene Silencing and Silencing Rescue in Plants PLoS One Binder A, Lambert J, Morbitzer R, Popp C, Ott T, Lahaye T, Parniske M DNA Assembly and Cloning,Golden Gate Assembly
2007 A multinuclear copper(I) cluster forms the dimerization interface in copper-loaded human copper chaperone for superoxide dismutase Biochem.  Stasser, J. P., et. al.
1999 A Mutant of BamHI Restriction Endonuclease which Requires N6-Methyladenine for Cleavage. J.Mol.Biol. Whitaker, R.D., Dorner, L.F.and Schildkraut, I.
1999 A natural example of protein trans-splicing. TIBS Perler, F.B.
2013 A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins. Nature Chemistry Lukinavicius, G., Umezawa, K., Olivier, N., Honigmann, A., Yang, G., Plas, T., Mueller, M., Reymond, L., Correa, I.R., Jr., Luo, Z.-G., Schultz, C., Lemke, E.A., Heppenstall, P., Eggeling, C., Manley, S. and Johnsson, K.
2015 A New Approach to Produce HIV-1 Envelope Trimers: BOTH CLEAVAGE AND PROPER GLYCOSYLATION ARE ESSENTIAL TO GENERATE AUTHENTIC TRIMERS. J Biol Chem AlSalmi W., Mahalingam M., Ananthaswamy N., Hamlin C., Flores D., Gao G., Rao V.B.
1997 A New Enhancer of Position-Effect Variegation in Drosophila melanogaster Encodes a Putative RNA Helicase That Binds Chromosomes and Is Regulated by the Cell Cycle. Genetics Society of America Eberl, D.F., Lorenz, L.J., Melnick, M.B., Sood, V., Lasko, P., and Perrimon, N.
2009 A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids PLoS One Ahier A. et al.
2009 A new member of the Eschericia coli fad regulon: transcriptional regulation of fadM (ybaW) J. Bacteriol. Feng, Y. and Cronan, J. E.
1990 A new type II restriction endonuclease, BsmAI, from Bacillus stearothermophilus. Nucl.Acids Res. Kong, H., Morgan, R.D., and Chen, Z.
1991 A new type II restriction endonuclease, BsoOI, from Bacillus stearothermophilus Chinese Sci. Bull Pan, X.S. and Chen, Z.F.
2003 A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucl.Acids Res. Roberts, R.J., Belfort, M.et al.
2004 A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids and Molecular Biology Roberts, R.J., Belfort, M.et al.
1991 A Novel Activity in Escherichia coli K-12 That Directs Restriction of DNA Modified at CG Dinucleotides. J.Bacteriol. Kelleher, J.E., and Raleigh, E.A.
1995 A novel beta-galactosidase gene isolated from the bacterium Xanthomonas manihotis exhibits strong homology to several eukaryotic beta-galactosidases. Glycobiology Taron, C.H., Benner, J.S., Hornstra, L.J., and Guthrie, E.P.
2002 A novel cyclophilin from parasitic and free-living nematodes with a unique substrate-and drug-binding domain. J.Biol.Chem. Ma, D., Nelson, L.S., LeCoz, K., Poole, C.and Carlow, C.K.S.
2016 A novel enrichment strategy reveals unprecedented number of novel transcription start sites at single base resolution in a model prokaryote and the gut microbiome. BMC Genomics Ettwiller, L., Buswell, J., Yigit, E. and Schildkraut, I
2010 A novel melanoma-targeting peptide screened by phage display exhibits antitumor activity J. Mol. Med. Matsuo, A.L. et al.
2010 A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery J. Control Release Li, Z.J. et. al.
2011 A peptide to dimerized translationally controlled tumor protein modulates allergic reactions J. Mol. Med. Kim, M.
2011 A phage-targeting startegy for the design of spatiotemporal drug delivery from grafted matrices Fibrogenesis Tissue Repair Sawada, R. et al.
2011 A piggyBac transposon-based mutagenesis system for the fission yeast Schizosaccharomyces pombe  Nuc. Acids Res. Li, J., Zhang, J.-M., Li, X. et al
2017 A practical guide to the oral microbiome and its relation to health and disease Krishnan, K., Chen, T., Paster, B.J.
2015 A Proline-Rich Domain in the Genotype 4 Hepatitis E Virus ORF3 PLoS One Wang H., Fangxiao J., Liang H., Gu H.
1995 A Promising Recombinant Antigen for the Early Detection of Heartworm Infection. Proceeding of the Heartworm Symposium Hong, X.Q., Mejia, J.S., Nkenfou, C., Perler, F.B., and Carlow, C.K.
2013 A Protocol for Construction of Gene Targeting Vectors and Generation of Homologous Recombinant Embryonic Stem Cells Methods in Molecular Biology Hicham Bouabe, Klaus Okkenhaug
2011 A Radically Different Mechanism for S-Adenosylmethionine-Dependent Methyltransferases. Science Express Grove, T.L., Benner, J.S., Radle, M.I., Ahlum, J.H., Landgraf, B.J., Krebs, C.and Booker, S.J.
2017 A refined DNA methylation detection method using MspJI coupled quantitative PCR Analytical Biochemistry Petell, C.J., Loiseau, G., Gandy, R., Pradhan, S., Gowher, H.
2011 A reporter system for assaying influenza virus RNP functionality based on secreted Gaussia luciferase activity Virology J. Zhu, W. et al.
2014 A restriction enzyme-powered autonomous DNA walking machine: its application for a highly sensitive electrochemiluminescence assay of DNA Nanoscale Ying Chen, Yun Xiang, Ruo Yuan, Yaqin Chai
2014 A robust TALENs system for highly efficient mammalian genome editing Sci Rep Feng Y, Zhang S, Huang X DNA Assembly and Cloning,Golden Gate Assembly
2008 A secreted luciferase for ex vivo monitoring of in vivo processes Nat. Methods Wurdinger, T., Badr, C., Pike, L., de Kleine, R., Weissleder, R. and Breakefield, X.O. and Tannous, B.A.
2008 A secreted luciferase for ex vivo monitoring of in vivo processes Nat. Methods Wurdinger, T., Badr, C., Pike, L., de Kleine, R., Weissleder, R., Breakefield, X.O., Tannous, B.A.
2014 A semi-synthetic organism with an expanded genetic alphabet Nature Malyshev, D.A., Dhami, K., Lavergne, T., chen, T., Dai, N., Foster, J.M., Correa Jr., I.R. and Romesberg, F.E.
2015 A Sensitive Approach to Map Genome-wide 5-Hydroxymethylcytosine and 5-Formylcytosine at Single-Base Resolution Mol. Cell Sun, Z., Dai, N., Borgaro, J.G., Quimby, A., Sun, D., Correa, I.R., Jr., Zheng, Y., Zhu, Z. and Guan, S.
2007 A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate Anal Biochem. Hassiepen, U., et. al.
1993 A sensitive serodiagnostic test for onchocerciasis using a cocktail of recombinant antigens. Am J Trop Med Hyg. Bradley, J.E., Trenholme, K.R., Gillespie, A.J., Guderian, R., Titanji, V., Hong, Y., and McReynolds, L.
2011 A set of aspartyl protease-deficient strains for improved expression of heterologous proteins in Kluyveromyces lactis FEMS Yeast Res. Ganatra, M.B., Rainauskas, S., Hong J.M., Taylor, T.E., Denson, J.P.M., Esposito, D., Read, J.D., Schmeisser, H., Zoon, K.C., Hartley, J.L. and Taron, C.H.