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We believe that basic research and the cultivation of scientific knowledge is critical for us to stay connected with our customers and to drive scientific breakthroughs. At NEB, over 30 labs participate in research projects, which are aided by post-doctoral fellows and students in Masters and Ph.D. programs. NEB researchers have authored or co-authored over 1,000 publications (as of 1/17) many of which are in peer-reviewed journals. Further, NEB products have been used successfully in numerous publications by scientists throughout the world.

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Year Title Journal Authors Application(s)
Optimization of Medium Composition for Production pf Recombinant
The level of synthesis and secretion of Gaussia princeps
Selection of a mimotope peptide of S-adenosyl-l-homocysteine and its application in immunoassays Molecules Wu, C. and Tzertzinis, G. Phage Display
Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice PLoS One Zahid, M. et al.
Targeting of tumor blood vessels
Production of disulfide-bonded proteins in Escherichia coli Berkmen, M.
Near-Infrared Fluorescence Imaging of Mammalian Cells and Xenograft Tumors with SNAP-tag PLoS ONE Gong, H.; Kovar, J. L.; Baker, B.; Zhang, A.; Cheung, L.; Draney, D. R.; Corrêa, I. R., Jr.; Xu, M.-Q.; Olive, M. D.
In vitro RNA interference and immunofluorescence-based phenotype analysis in a human parasitic nematode, Brugia malayi Parasites and Vectors Landmann, F., Foster, J.M., Slatko, B.E. and Sullivan, W.
Database of DNA polymerases Curr Protoc Mol Biol. Langhorst, B.W. and Nichols, N.M.
An insight into the various regulatory mechanisms modulating human DNA methyltransferase 1 stability and function Epigenetics Kar, S., Deb, M., Sengupta, D. Shilpi, A., Parbin, S., Torrisani, J., Pradhan, S. and Patra, S.
waffles
Screening of genetic parameters for soluble protein expression in Escherichia coli Protein Expression and Purification Vernet, E., Kotzsch, A., Voldborg, B., et al.
"Bacterial Systems" introduction of Membrane Proteins - Strategies for Expression and Isolation Samuelson, J.C.
Culture-independent genomic characterisation of Candidatus Chlamydia
Structural basis for human PRDM9 action at recombination hot spots. Genes Dev. Patel, A., Horton, J.R., Wilson, G.G., Zhang, X. and Cheng, X.
Rapid Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components
Efficient DNA ligation in DNA-RNA hybrid helices by Chlorella
1980 The Evolution of Genes: the Chicken Preproinsulin Gene Cell Perler, F.B.and Efstratiadis, A.
1980 Restriction endonucleases from three strains of Haemophilus influenzae Sci. Sin. Shen, S.X., Li, Q.L., Yan, P,F., Zhou, B., Ye, S.Y., Lu, Y.Y., Wang, D.B.
1981 Two new restriction endonucleases from Proteus vulgaris. Nucl.Acids Res. Gingeras, T.R., Greenough, L., Schildkraut, I., and Roberts, R.J.
1982 NdeI: a restriction endonuclease from Neisseria denitrificans which cleaves DNA at 5'-CATATG-3' sequences. FEBS Lett. Watson, R.J., Schildkraut, I., Qiang, B.Q., Martin, S.M., and Visentin, L.P.
1983 Analysis of Regulation of phoB Expression Using a phoB-cat Fusion. J.Bacteriol. Guan, C., Wanner, B., and Inouye, H.
1983 The isolation and characterization of the Escherichia coli DNA adenine methylase (dam) gene Nucleic Acids Res. Brooks, J.E., Blumenthal, R.M., Gingeras, T.R.
1984 DNA modification methylases: New uses in the manipulation of DNA. BioTechniques Christ, C., and Nelson, M.
1984 Alteration of apparent restriction endonuclease recognition specificities by DNA methylases. Nucl.Acids Res. Nelson, M., Christ, C., and Schildkraut, I.
1984 Screening for and characterizing restriction endonucleases Genetic Engineering Schildkraut, I.
1984 The cleavage site for the restriction endonuclease EcoRV is 5'-GAT^ATC-3'. Gene Schildkraut, I., Banner, C.D.B., Rhodes, C.S., and Parekh, S.
1984 Acetylcholinesterase secreted by intestinal nematodes: a reinterpretation of its putative role of "biochemical holdfast." Trans.Royal Soc Trop.Med.and Hyg. Philipp, M.
1984 A type II restriction endonuclease with an eight nucleotide specificity from Streptomyces fimbriatus. Nucl.Acids.Res. Qiang, B.Q., and Schildkraut, I.
1985 Nuclear and Mitochondrial DNA of the Primate Malarial Parasite Plasmodium Knowlesi. Mol.Biochem.Parasitol. Williamson, D.H., Wilson, R.J., Bates, P.A., McCready, S., Perler, F., and Qiang, B.Q.
1985 Nucleotide sequence of the PaeR7 restriction/modification system and partial characterization of its protein products. Nucl.Acids Res. Theriault, G., Roy, P.H., Howard, K.A., Benner, J.S., Brooks, J.S., Waters, A.F., and Gingeras, T.R.
1985 The effect of site specific methylation on restriction endonuclease digestion. Nucl.Acids Res. McClelland, M., and Nelson, M.
1985 Purification of MboII methylase (GAAGmA) from Moraxella bovis: site specific cleavage of DNA at nine and ten base pair sequences. Nucl.Acids Res. McClelland, M., Nelson, M., and Cantor, C.R.
1986 Sequencing in the Fast Lane: A Rapid Protocol for [a-35S] dATP Dideoxy DNA Sequencing. BioTechniques Williams, S.A., Slatko, B.E., Moran, L.S., and DeSimone, S.M.
1986 Escherichia coli K-12 restricts DNA containing 5-methylcytosine. Proc.Natl.Acad.Sci.USA Raleigh, E.A., and Wilson, G.
1986 Two unique restriction endonucleases from Neisseria lactamica. Nucl.Acids Res. Qiang, B.Q., and Schildkraut, I.
1986 Biochemical and immunologic characterization of a major surface antigen of Dirofilaria immitis infective larvae. J.Immunol. Philipp, M., and Davis, T.B.
1986 Cloning and comparison of repeated DNA sequences from the human filarial parasite Brugia malayi and the animal parasite Brugia pahangi. Proc.Natl.Acad.Sci.USA McReynolds, L.A., DeSimone, S.M., and Williams, S.A.
1986 Cloning and characterization of two Onchocerca volvulus repeated DNA sequences. Mol.Biochem.Parasitol. Perler, F.B., and Karam, M.
1986 Cloning the DdeI restriction-modification system using a two-step method. Nucl.Acids Res. Howard, K.A., Card, C., Benner, J.S., Callahan, H.L., Maunus, R., Silber, K., Wilson, G., and Brooks, J.E.
1987 NotI and SfiI: restriction endonucleases with octanucleotide recognition sequences. Methods Enzymol. Qiang, B.-Q., and Schildkraut, I.
1987 Properties and uses of restriction endonucleases. Methods Enzymol. Brooks, J.E.
1987 N4-Methylcytosine as a minor base in bacterial DNA. J.Bacteriol. Ehrlich, M., Wilson, G.G., Kenneth, C.K., and Gehrke, C.W.
1987 Nucleotide sequence of the DdeI restriction-modification system and characterization of the methylase protein. Nucl.Acids Res. Sznyter, L.A., Slatko, B., Moran, L., O'Donnell, K.H., and Brooks, J.E.
1987 Monoclonal antibody to a unique surface epitope of the human filaria Brugia malayi identifies infective larvae in mosquito vectors. Proc.Natl.Acad.Sci.USA Carlow, C.K.S., Franke, E.D., Lowrie, R.C.J., Partono, F., and Philipp, M.
1987 Highly Repeated DNA Sequences as Species-specific Probes for Brugia. Parasitology Today Piessens, W.F., McReynolds, L.A.and Williams, S.A.
1987 Genomic Cloning of Recombinant Antigens Detected by Antiserum Against Infective Larvae of Brugia Malayi. Molecular Paradigms for Eradicating Helminthic Parasites Arasu, P., and Perler, F.B.
1987 Monoclonal antibodies to parasite antigens: a rapid immunization protocol requiring small numbers of parasites. J.Parasitol. Carlow, C.K.S., Edwards, M.K., James, E.R., and Philipp, M.
1987 Isolation and Identification of restriction endonuclease BstFI Nucl.Acids Res. Kong, H and Chen, Z.
1987 The use of DNA methylases to alter the apparent recognition specificities of restriction endonucleases. Methods Enzymol. Nelson, M., and Schildkraut, I.
1987 The effect of site-specific methylation on restriction-modification enzymes. Nucl.Acids Res. Nelson, M., and McClelland, M.
1987 The Use of DNA Sequencing Reactions as Probes for Southern Blots, Dot Blots and Colony Hydridizations. BioTechniques Card, C.O., Williams, S.A., Moran, L.S., Poole, C.B., and Slatko, B.E.
1987 The cleavage site for the restriction endonucleases BanI and HgiCI is 5' ...G^GPyPuCC ...3'. Nucl.Acids Res. Schildkraut, I., Lynch, J., and Morgan, R.
1987 Purification and assay of Type II DNA methylases. Methods Enzymol. Nelson, M., and McClelland, M.
1987 Protective immunity to Brugia malayi larvae in BALB/c mice: potential of this model for the identification of protective antigens. Am.J.Trop.Med.Hyg. Carlow, C.K.S., and Philipp, M.
1987 Restriction endonucleases for pulsed field mapping of bacterial genomes. Nucl.Acids Res. McClelland, M., Jones, R., Patel, Y., and Nelson, M.
1987 Restriction and modification in vivo by Escherichia coli K12 Methods Enzymol. Raleigh, E.A.
1987 Enhancement of the apparent cleavage specificities of restriction endonucleases: applications to megabase mapping of chromosomes. McClelland, M., and Nelson, M.
1987 Cloning of two type II methylase genes that recognise asymmetric nucleotide sequences: FokI and HgaI. Mol.Gen.Genet. Nwankwo, D., and Wilson, G.
1987 Cloning and characterization of an abundant Plasmodium knowlesi antigen which cross reacts with Gambian sera. Mol.Biochem.Parasitol. Perler, F.B., Moon, A.M., Qiang, B.-Q., Meda, M., Dalton, M., Card, C., Schmidt-Ullrich, R., Wallach, D., Lynch, J., and Donelson, J.E.
1987 Cloning, sequencing and expression of the TaqI restriction-modification system. Nucl.Acids Res. Slatko, B.E., Benner, J.S., Jager-Quinton, T., Moran, L.S., Simcox, T.G., VanCott, E.M., and Wilson, G.G.
1987 Cloning, sequencing, in vivo promoter mapping, and expression in Escherichia coli of the gene for the HhaI methyltransferase. J.Biol.Chem. Caserta, M., Zacharias, W., Nwankwo, D., Wilson, G.G., and Wells, R.D.
1987 Brugia malayi: recombinant antigens expressed by genomic DNA clones. Exp.Parasitol. Arasu , P., Philipp, M., and Perler, F.
1987 A unique type II restriction endonuclease from Acinetobacter lwoffi N. Nucl.Acids Res. Morgan, R.D., Dalton, M., and Stote, R.
1987 A Developmentally regulated surface epitope expressed by the infective larva of Brugia malayi which is rapidly lost after infection. Molecular Paradigms for Eradicating Helmenthic Parasites Carlow, C.K.S., Perrone, J., Spielman, A., and Philipp, M.A.
1987 Dirofilaria immitis: Genomic Complexity and Characterication of a Structural Gene. Molecular Paradigms for Eradicating Helminthic Parasites Maina, C.V., Grandea, A.G.I., Le, T.K.T., Nur, A., Williams, S.A., and McReynolds, L.A.
1988 AseI, a restriction endonuclease from Aquaspirillum serpens which recognizes 5'ATTAAT3'. Nucl.Acids Res. Polisson, C., and Morgan, R.D.
1988 An Escherichia coli vector to express and purify foreign proteins by fusion to and separation from maltose-binding protein. Gene Maina, C.V., Riggs, P.D., Grandea, A.G.I., Slatko, B.E., Moran, L.S., Tagliamonte, J.A., McReynolds, L.A., and Guan, C.D.
1988 BsrI, a unique restriction endonuclease from Bacillus stearothermophilus which recognizes 5'ACTGG3'. Nucl.Acids Res. Polisson, C., and Morgan, R.D.
1988 Cloned restriction-modification systems - a review. Gene Wilson, G.G.
1988 Characterization of clones of the BamHI methyltransferase gene. Gene Nathan, P.D.and Brooks, J.E.
1988 A site-specific single strand endonuclease activity induced by NYs-1 virus infection of a Chlorella-like green alga. Nucl.Acids Res. Xia, Y., Morgan, R., Schildkraut, I., and Van Etten, J.L.
1988 Cloning and analysis of the HaeIII and HaeII methyltransferase genes. Gene Slatko, B.E., Croft, R., Moran, L.S., and Wilson, G.G.
1988 Cloning Type II restriction and modification genes. Gene Lunnen, K.D., Barsomian, J.M., Camp, R.R., Card, C.O., Chen, S.Z., Croft, R., Looney, M.C., Meda, M.M., Moran, L.S., Nwankwo, D.O., Slatko, B.E., Van Cott, E.M., and Wilson, G.G.
1988 Cloning the FnuDI, NaeI, NcoI and XbaI restriction-modification systems. Gene Van Cott, E.M., and Wilson, G.G.
1988 EarI, a restriction endonuclease from Enterobacter aerogenes which recognizes 5'CTCTTC3'. Nucl.Acids Res. Polisson, C., and Morgan, R.D.
1988 IMMUNITY IN FILARIASIS: Perspectives for Vaccine Development. Ann.Rev.Microbiol. Philipp, M., Davis , T.B., Storey, N., and Carlow, C.K.S.
1988 Genetic dissection of the methylcytosine-specific restriction system mcrB of Escherichia coli K-12. Gene Dila, D., and Raleigh, E.A.
1988 Cloning and sequencing the HinfI restriction and modification genes. Gene Chandrasegaran, S., Lunnen, K.D., Smith, H.O., and Wilson, G.G.
1988 Cloning and expression of the MspI restriction and modification genes. Gene Nwankwo, D.O., and Wilson, G.G.
1988 Cloning of the HhaI and HinPI restriction-modification systems. Gene Barsomian, J.M., Card, C.O., and Wilson, G.G.
1988 Cloning, purification and characterization of the M.NdeI methyltransferase from Neisseria denitrificans Gene Silber, K.R., Polisson, C., Rees, P.A., and Benner, J.S.
1988 Cloning, purification and characterization of the HincII and HindII methyltransferases from Haemophilus influenzae. Gene Rees, P.A., Nwankwo, D.O., Wilson, G.G., and Benner, J.S.
1988 The characterization and cloning of the EagI restriction-modification system. Gene Sznyter, L.A., and Brooks, J.E.
1988 The Amino Acid Sequence of the Eukaryotic DNA [N6-adenine] Methyltransferase, M-CviBIII, Has Regions of Similarity With the Prokaryotic Isoschizomer M-TaqI and Other DNA [N6-adenine] Methyltransferases. Gene Narva, K.E., Van Etten, J.L., Slatko, B.E.and Benner, J.S.
1988 Type II restriction-modification systems. Trends in Genetics Wilson, G.G.
1988 Vectors that facilitate the expression and purification of foreign peptides in Escherichia coli by fusion to maltose-binding protein. Gene Guan, C.D., Li, P., Riggs, P.D., and Inouye, H.
1988 MseI, a unique restriction endonuclease from Micrococcus species which recognizes 5'T^TAA 3'. Nucl.Acids Res. Morgan, R.D.
1988 Isolation and characterization of restriction endonuclease BstYI from Bacillus stearothermophilus. FEBS Lett. Chen Z.and Kong, H.
1988 McrA and McrB restriction phenotypes of some E.coli strains and implications for gene cloning. Nucl.Acids Res. Raleigh, E.A., Murray, N.E., Revel, H., Blumenthal, R.M., Westaway, D., Reith, A.D., Rigby, P.W.J., Elhai, J., and Hanahan, D.
1988 Nomenclature for bacterial genes coding for class-II restriction endonucleases and modification methyltransferases. Gene Szybalski, W., Blumenthal, R.M., Brooks, J.E., Hattman, S., and Raleigh, E.A.
1988 Species-specific oligonucleotide probes for the identification of human filarial parasites. Mol.Biochem.Parasitol. Williams, S.A., DeSimone, S.M., and McReynolds, L.A.
1988 Cloning and characterization of the BamHI restriction modification system Gene Brooks, J.E., Benner, J.S., Silber, K.R., Heiter, D.F., Sznyter, L.A., Jager-Quinton, T., Wilson, G.G., Moran, L.S., Slatko, B.E., Nwankwo, D.O.
1988 Isolation and properties of a new site specific endonuclease Bme142I from Bacillus megaterium Nucleic Acids Res. Fomenkov, A.I., Kramarov, V.M., Andreev, L.V., Mochalov, V.V., Smolyaninov, V.V., Matvienko, N.I.
1988 The characterization and cloning of the NotI restriction-modification system Heredity Sznyter, L.A., Brooks. J.E.
1989 A l gt11 cDNA recombinant that encodes Dirofilaria immitis paramyosin. Mol.Biochem.Parasitol. Grandea, A.G.I., Le, T.K.T., Asikin, N., Davis, T.B., Philipp, M., Cohen, C., and McReynolds, L.A.
1989 Characterization and cloning of MwoI (GCN7GC), a new type-II restriction-modification system from Methanobacterium wolfei. Gene Lunnen, K.D., Morgan, R.D., Timan, C.J., Krzycki, J.A., Reeve, J.N., and Wilson, G.G.
1989 M.FokI methylates adenine in both strands of its asymmetric recognition sequence. Gene Landry, D., Looney, M.C., Feehery, G.R., Slatko, B.E., Jack, W.E., Schildkraut, I., and Wilson, G.G.
1989 Isolation and characterization of restriction endonuclease BstFI and BstSI from Bacillus stearothermophilus. J.Fudan Univ.Natural Sci. Chen Z., Kong, H.and Wang, L.
1989 MscI, a type II restriction endonuclease from Micrococcus species which recognizes 5' TGGCCA 3'. Nucl.Acids Res. Polisson, C.
1989 Use of Degenerate Oligonucleotides for Amplification of the nifH Gene from the Marine Cyanobacterium Trichodesmium thiebautii. Appl.Environ.Microbiol., Zehr, J.P., and McReynolds, L.A.
1989 Nucleotide sequence of the FokI restriction-modification system: separate strand-specificity domains in the methyltransferase. Gene Looney, M.C., Moran, L.S., Jack, W.E., Feehery, G.R., Benner, J.S., Slatko, B.E., and Wilson, G.G.
1989 DrdI, a unique restriction endonuclease from Deinococcus radiodurans which recognizes 5'GACN6GTC3'. Nucl.Acids Res. Polisson, C., and Morgan, R.D.
1989 Cloning the BamHI restriction modification system. Nucl.Acids Res. Brooks, J.E., Benner, J.S., Heiter, D.F., Silber, K.R., Sznyter, L.A., Jager-Quinton, T., Moran, L.S., Slatko, B.E., Wilson, G.G., and Nwankwo, D.O.
1989 Genetic and physical mapping of the mcrA (rglA) and mcrB (rglB) loci of Escherichia coli K-12. Genetics Raleigh, E.A., Trimarchi, R., and Revel, H.
1989 Introduction of prokaryotic HhaI DNA methyltransferase alters the phenotype of 3T3 cells. Proc.Am.Assoc.Cancer Res. Herman, J., Nelkin, B., Mabry, M., Wilson, G., and Baylin, S.
1989 Human T-cell stimulation, molecular characterization and in situ mRNA localization of a Brugia malayi recombinant antigen. Mol.Biochem.Parasitol. Arasu, P., Nutman, T.B., Steel, C., Mulligan, M.M., Abraham, D., Tuan, R.S., and Perler, F.B.
1989 Site-directed mutagenesis of the EcoRV methylase for the study of the functional role of the conserved sequences in N6-adenine methylases J. Cell Biochem Barshevsky,T. and Benner J.S.
1989 Characterization of clones of the BamHI methyltransferase gene J. Cell Biochem. Nathan, P.D. and Brooks. J.E.
1990 Cloning and characterization of the HpaII methylase gene. Nucl.Acids Res. Card, C.O., Wilson, G.G., Weule, K., Hasapes, J., Kiss, A., and Roberts, R.J.
1990 Cleavage at the twelve-base-pair sequence 5'-TCTAGATCTAGA-3' using M.XbaI (TCTAGm6A) methylation and DpnI (Gm6A/TC) cleavage. Nucl.Acids Res. Patel, Y., Van Cott, E., Wilson, G.G., and McClelland, M.
1990 Cloning, characterization, and expression in Escherichia coli of the gene coding for the CpG DNA methylase from Spiroplasma sp.strain MQ1(M.SssI). Nucl.Acids Res. Renbaum, P., Abrahamove, D., Fainsod, A., Wilson, G.G., Rottem, S., and Razin, A.
1990 Filarial paramyosin: cDNA sequences from Dirofilaria immitis and Onchocerca volvulus. Mol.Biochem.Parasitol. Limberger, R.J., and McReynolds, L.A.
1990 Field testing of monoclonal probe specific for infective larvae of human Brugian parasites. Parasites: Molecular Biology, Drug and Vaccine Design Carlow, C.K.S., Suwita, A., Bahang, Z., Purnomo, Partono, F., and Philipp, M.
1990 Altered specificity of restriction endonucleases HinfI. Nucl.Acids Res. Petronzio, T., and Schildkraut, I.
1990 AciI, a unique restriction endonuclease from Arthrobacter citreus which recognizes 5' CCGC3'. Nucl.Acids Res. Polisson, C., and Morgan, R.D.
1990 Antigenic and dynamic properties of the surface of Onchocerca microfilariae. Trop.Med.Parasitol. Edwards, M.K., Busto, P., James, E.R., Carlow, C.K.S., and Philipp, M.
1990 B CELL RESPONSES TO PARAMYOSIN.Isotypic Analysis and Epitope Mapping of Filarial Paramyosin in Patients with Onchocerciasis. J.Immunol. Steel, C., Limberger, R.J., McReynolds, L.A., Ottesen, E.A., and Nutman, T.B.
1990 Anti-idiotypic antibodies function as a surrogate surface epitope of Brugia malayi infective larvae. Acta Trop. Carlow, C.K.S., Busto, P., Storey, N., and Philipp, M.
1990 Genetic and sequence organization of the mcrBC locus of Escherichia coli K-12. J.Bacteriol. Dila, D., Sutherland, E., Moran, L., Slatko, B., and Raleigh, E.A.
1990 Nucleotide sequence of the phage l gt11 SacI-KpnI lacZ region. Gene Moran, L.S., Maina, C.V., Poole, C.B., and Slatko, B.E.
1990 Identification of a new type II restriction endonuclease BsaAI. Nucl.Acids Res. Kong, H., Morgan, R.D., and Chen, Z.
1990 The identification of an Onchocerca-specific recombinant antigen containing a T cell epitope. J Immunol. Colina, K.F., Perler, F.B., Matsumura, I., Meda, M., and Nutman, T.B.
1990 A new type II restriction endonuclease, BsmAI, from Bacillus stearothermophilus. Nucl.Acids Res. Kong, H., Morgan, R.D., and Chen, Z.
1990 Cloning and Characterization of the SphI restriction modification system from Streptomyces phaeochromogenes J Cell Biochem Brooks, J.E., Sznyter, L., Vaccaro, C., Arnaud, M., Jager-Quinton, T., Wilson, G., Moran, L., Slatko, B., Bernan, V.
1990 Structural studies opf the BamHI restriction enzyme Biophys. J. Strzelecka, T., Dorner, L., Schildkraut, I., Aggarawal, A.
1991 Overexpression, purification and crystallization of BamHI endonuclease. Nucl.Acids Res. Jack, W.E., Greenough, L., Dorner, L.F., Xu, S.Y., Strzelecka, T., Aggarwal, A.K., and Schildkraut, I.
1991 Organization of restriction-modification systems. Nucl.Acids Res. Wilson, G.G.
1991 Restriction and Modification Systems. Ann.Rev.Genet. Wilson, G.G., and Murray, N.E.
1991 Filarial DNA probes in Jakarta. Parasitol.Today McReynolds, L.A., Poole, C.B., and Williams, S.A.
1991 Cross-linking of a monoclonal antibody-antigen complex enables detection of parasite antigen in immunoblots and in an expression library. Mol.Biochem.Parasitol. Awobuluyi, M., Mania, C.V., and Carlow, C.K.S.
1991 Histochemical localization of gene expression in Onchocerca volvulus: in situ DNA histohybridization and immuno-cytochemistry. Mol.Biochem.Parasitol. Tuan, R.S., Shepley, K.J., M.M., M., Abraham, D., and Perler, F.B.
1991 Nomenclature relating to restriction of modified DNA in Escherichia coli. J.Bacteriol. Raleigh, E.A., Benner, J., Bloom, F., Braymer, H.D., DeCruz, E., Dharmalingam, K., Heitman, J., Noyer-Weidner, M., Piekarowicz, A., Kretz, P.L., Short, J.M., and Woodcock, D.
1991 Isolation of BamHI variants with reduced cleavage activities. J.Biol.Chem. Xu, S.Y., and Schildkraut, I.
1991 Chacterization of Expression of the Escherichia coli Mrr Restriction System. J.Bacteriol. Waite-Rees, P.A., Keating, C.J., Moran, L.S., Slatko, B.E., Hornstra, L.J., and Benner, J.S.
1991 BfaI, a new MaeI isoschizomer from Bacteroides fragilis, recognizes the sequence 5' C^TAG 3'. Nucl.Acids Res. Reinecke, S.N., and Morgan, R.D.
1991 Characterization of a recombinant clone of Wuchereria bancrofti with specificity for human lymphatic filarial parasites. Mol.Biochem.Parasitol. Raghavan, N., McReynolds, L.A., Maina, C.V., Feinstone, S.M., Jayaraman, K., Ottesen, E., and Nutman, T.B.
1991 Cofactor requirements of BamHI mutant endonuclease E77K and its suppressor mutants. J.Bacteriol. Xu, S.Y., and Schildkraut, I.
1991 Characterization of the cloned BamHI restriction modification system: its nucleotide sequence, properties of the methylase, and expression in heterologous hosts. Nucl.Acids Res. Brooks, J.E., Nathan, P.D., Landry, D., Sznyter, L.A., Waite-Rees, P., Ives, C.L., Moran, L.S., Slatko, B.E., and Benner, J.S.
1991 Application of a novel chemiluminescence-based DNA detection method to single-vector and multiplex DNA sequencing. BioTechniques Creasey, A., D'Angio, L., Dunne, T.S., Kissinger, C., O'Keefe, T., Perry-O'Keefe, H., Moran, L.S., Roskey, M., Schildkraut, I.and Sears, L.E.
1991 A Novel Activity in Escherichia coli K-12 That Directs Restriction of DNA Modified at CG Dinucleotides. J.Bacteriol. Kelleher, J.E., and Raleigh, E.A.
1991 A new type II restriction endonuclease, BsoOI, from Bacillus stearothermophilus Chinese Sci. Bull Pan, X.S. and Chen, Z.F.
1992 Using Molecular Biological Techniques to Identify and Study Gene Products Involved in Dirofilarial Immunoprophylaxis. American Heartworm Society Hough, D.M., Awobuluyi, M.E., McReynolds, L.A., Carlow, C.K.S., and Maina, C.V.
1992 Transmission-blocking antibodies recognize microfilarial chitinase in brugian lymphatic filariasis. Proc.Natl.Acad.Sci.USA Fuhrman, J.A., Lane, W.S., Smith, R.F., Piessens, W.F., and Perler, F.B.
1992 The corrected nucleotide sequences of the TaqI restriction and modification enzymes reveal a thirteen-codon overlap. Gene Barany, F., Slatko, B., Danzitz, M., Cowburn, D., Schildkraut, I., and Wilson, G.G.
1992 ApoI, a unique restriction endonuclease from Arthrobacter protophormiae which recognizes 5' RAATTY-3'. Nucl.Acids Res. Polisson, C., and Robinson, D.
1992 Amino acid sequence arrangements of DNA-methyltransferases. Methods Enzymol. Wilson, G.G.
1992 Brugia malayi: patterns of expression of surface-associated antigens. Exp.Parasitol. Storey, N.and Philipp, M.
1992 McrBC: a multisubunit GTP-dependent restriction endonuclease. J.Mol.Biol. Sutherland, E., Coe, L., and Raleigh, E.A.
1992 Intervening sequences in an Archaea DNA polymerase gene. Proc.Natl.Acad.Sci.USA Perler, F.B., Comb, D.G., Jack, W.E., Moran, L.S., Qiang, B., Kucera, R.B., Benner, J., Slatko, B.E., Nwankwo, D.O., Hempstead, S.K., Carlow, C.K.S.and Jannasch, H.
1992 Organization and function of the mcrBC genes of Escherichia coli K-12. Mol.Microbiol Raleigh, E.A.
1992 Regulation of the BamHI restriction-modification system by a small intergenic open reading frame, bamHIC, in both Escherichia coli and Bacillus subtilis. J.Bacteriol. Ives, C.L., Nathan, P.D., and Brooks, J.E.
1992 Protein splicing removes intervening sequences in an archaea DNA polymerase. Nucl.Acids Res. Hodges, R.A., Perler, F.B., Noren, C.J., and Jack, W.E.
1992 Characterization of Type II DNA-Methyltransferases. Methods Enzymol. Landry, D., Barsomian, J.M., Feehery, G.R., and Wilson, G.G.
1992 Characterization of a muscle-associated antigen from Wuchereria bancrofti. Exp.Parasitol. Raghavan, N., Maina, C.V., Fitzgerald, P.C., Tuan, R.S., Slatko, B.E., Ottesen, E.A., and Nutman, T.B.
1992 CircumVent» Thermal Cycle Sequencing and Alternative Manual and Automated DNA Sequencing Protocols Using the Highly Thermostable VentR» (exo-) DNA Polymerase. BioTechniques Sears, L.E., Moran, L.S., Kissinger, C., Creasey, T., Perry-O'Keefe, H., Roskey, M., Sutherland, E., and Slatko, B.E.
1992 Identification of surrogate rodent hosts for larval Onchocerca lienalis and induction of protective immunity in a model system. J Parasitol. Abraham, D., Eberhard, M.L., Lange, A.M., Yutanawiboonchai, W., Perler, F.B.and Lok, J.B.
1992 Cloning of a cuticular antigen that contains multiple tandem repeats from the filarial parasite Dirofilaria immitis. Proc.Natl.Acad.Sci.USA Poole, C.B., Grandea, A.G., III, Maina, C.V., Jenkins, R.E., Selkirk, M.E., and McReynolds, L.A.
1993 Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine. Cell Cheng, X., Kumar, S., Posfai, J., Pflugrath, J.W., and Roberts, R.J.
1993 McrBC, a novel multisubunit GTP-dependent restriction endonuclease. J.Cell Biochem.Suppl. Raleigh, E., Dila, D., Sutherland, E., Kelleher, J., Moran, L., Slatko, B., and Briggs, P.
1993 In vitro protein splicing of purified precursor and the identification of a branched intermediate. Cell Xu, M.Q., Southworth, M.W., Mersha, F.B., Hornstra, L.J., and Perler, F.B.
1993 REBASE-restriction enzymes and methylases. Nucl.Acids Res. Roberts, R.J.and Macelis, D.
1993 Protecting Recognition Sequences on DNA by a Cleavage-Deficient Restriction Endonuclease. BioTechniques Xu, S., and Schildkraut, I.
1993 Characterization of DNA Polymerase from the Hyperthermophile Archaea Thermococcus litoralis. J.Biol.Chem. Kong, H., Kucera, R.B., and Jack, W.E.
1993 Brugia pahangi and Brugia malayi: A Surface-Associated Glycoprotein (gp15/400) is Composed of Multiple Tandemly Repeated Units and Processed from a 400-kDa Precursor1. Exp.Parasitol. Tweedie, S., Paxton.W, A., Ingram, L., Maizels, R.M., McReynolds, L.A., and Selkirk, M.E.
1993 Compilation of Commercially Available Nucleases Nucleases Schildkraut, I.
1993 A sensitive serodiagnostic test for onchocerciasis using a cocktail of recombinant antigens. Am J Trop Med Hyg. Bradley, J.E., Trenholme, K.R., Gillespie, A.J., Guderian, R., Titanji, V., Hong, Y., and McReynolds, L.
1993 Brugia malayi and Brugia pahangi: synthetic biotin labeling of oligonucleotide probes for use in species-specific detection assays. Exp.Parasitol. Williams, S.A., Poole, C.B., Landry, D., Glover, J., and McReynolds, L.A.
1993 A unique restriction endonuclease, BcgI, from Bacillus coagulans. Nucl.Acids Res. Kong, H., Morgan, R.D., Maunus, R.E., and Schildkraut, I.
1993 Crystal Structure of the HhaI DNA Methyltransferase. Cheng, X., Kumar, S., Klimasauskas, S., and Roberts, R.J.
1993 Recent Advances in the Application of Molecular Biology in Filariasis. Proceeding of the 34th SEAMEO TROPMED Regional Seminar: Southeast Asian Journal of Tropical Medicine and Public Health McReynolds, L.A., Poole, C., Hong, Y., Williams, S.A., Partono, F., and Bradley, J.
1993 Restriction enzymes from Campylobacter coli strains. Acta gastroenterol.belg. Vitor, J.M.B., Polisson, C., Cabrita, J., and Silva, R.V.C.
1993 The M.AluI DNA-(cytosine C5)-methyltransferse has an unusually large, partially dispensable, variable region. Nucl.Acids Res. Zhang, B., Tao, T., Wilson, G.G., and Blumenthal, R.M.
1993 Type II Restriction Endonucleases Nucleases Roberts, R.J.and Halford, S.E.
1993 Workshop of DNA Probes and PCR for Detection of Filarial Parasies in Vectors Williams, S.A.
1993 The Polyprotien Allergens of Nematodes. Parasitol.Today McReynolds, L.A., Kennedy, M.W., and Selkirk, M.E.
1993 The Restriction Enzymes Nucleases Roberts, R.J.and Macelis, D.
1993 Cloning, sequencing and overexpressing the NaeI restriction endonuclease gene from Nocardia aerocolonigenes J Cell Biochem Taron, C.H., Van Cott, E.M., Wilson, G.G., Moran, L.S., Slatko, B.E., Hornstra, L.J., Benner, J.S., Kucera, R.B. and Guthrie, E.P.
1994 An amazing distortion in DNA induced by a methyltransferase (Nobel lecture) Bioscience Reports Roberts, R.J.
1994 An amazing distortion in DNA induced by a methyltransferase (Nobel lecture) Angew.Chem.Int.Ed.Engl. Roberts, R.J.
1994 An analysis of the humoral immune response of dogs following vaccination with irradiated infective larvae of Dirofilaria immitis. Parasite Immunol. Mejia, J.S., and Carlow, C.K.S.
1994 DNA sequencing Curr.Protoc.Mol.Biol. Slatko, B., Heinrich, P., Nixon, B.T., Eckert, R.L., Albright, L., and Ausubel, F.
1994 Direct selection of binding proficient/catalytic deficient variants of BamHI endonuclease. Nucl.Acids.Res. Dorner, L.F., and Schildkraut, I.
1994 Expression of an Onchocerca volvulus Ov33 homolog in Dirofilaria immitis: potential in immunodiagnosis of heartworm infection. Parasite Immunol. Mejia, S.J., Knenfou, C., Southworth, M.W., Perler, F.B.and Carlow, C.K.
1994 Fibroblast growth factor and cyclic AMP (cAMP) synergistically active gene expression at a cAMP response element. Mol.Cell.Biol. Tan, Y., Low, K.G., Boccia, C., Grossman, J., and Comb, M.J.
1994 Expression, purification, and crystallization of restriction endonuclease PvuII with DNA containing its recognition site Proteins Balendiran, K., Bonventre, J., Knott, R., Jack, W., Benner, J., Schildkraut, I., and Anderson, J.E.
1994 Cloning, analysis and expression of the HindIII R-M-encoding genes. Gene Nwankwo, D.O., Moran, L.S., Slatko, B.E., Waite-Rees, P.A., Dorner, L.F., Benner, J.S., and Wilson, G.G.
1994 Characterization of BcgI, a new kind of restriction-modification system. J.Biol.Chem. Kong, H., Roemer, S.E., Waite-Rees, P.A., Benner, J.S., Wilson, G.G., and Nwankwo, D.O.
1994 Construction of pSC101 derivatives with Camr and Tetr for selection or LacZ' for blue/white screening. BioTechniques Xu, S.Y., and Fomenkov, A.
1994 Crystallization and Preliminary X-ray Analysis of Restriction Endonuclease BamHI-DNA Complex. J.Mol.Biol. Strzelecka, T., Newman, M., Dorner, L.F., Knott, R., Schildkraut, I., and Aggarwal, A.K.
1994 Crystallization and Preliminary Crystallographic Analysis of Two Endo-b-N-acetylglucosaminidases, Endo H and Endo F1. J.Mol.Biol. Van Roey, P., Silva, G.H., Rao, V., Plummer, J., T.H., Tarention, A.L., and Guan, C.
1994 Protein splicing: an analysis of the branched intermediate and its resolution by succinimide formation. EMBO J. Xu, M.Q., Comb, D.G., Paulus, H., Noren, C.J., Shao, Y., and Perler, F.B.
1994 Organization and sequence of the SalI restriction-modification system. Gene Rodicio, M.R., Quinton-Jager, T., Moran, L.S., Slatko, B.E., and Wilson, G.G.
1994 Protein splicing elements: inteins and exteins - a definition of terms and recommended nomenclature. Nucl.Acids Res. Perler, F.B., Davis, E.O., Dean, G.E., Gimble, F.S., Jack, W.E., Neff, N., Noren, C.J., Thorner, J., and Belfort, M.
1994 Response to UV Damage by Four Escherichia coli K-12 Restriction Systems. J.Bacteriol. Kelleher, J.E., and Raleigh, E.A.
1994 REBASE - restriction enzymes and methylases Nucl.Acids.Res. Roberts, R.J.and Macelis, D.
1994 Histone-encoding genes from Pyrococcus: evidence for members of the HMf family of archaeal histones in a non-methanogenic Archaeon*. Gene Sandman, K., Perler, F.B., and Reeve, J.N.
1994 Hhal Methyltransferase Flips its Target Base Out of the DNA Helix. Cell Klimasauskas, S., Kumar, S., Roberts, R.J., and Cheng, X.
1994 Ligand-induced conformational states of the cytosine-specific DNA methyltransferase M.HgaI-2. J.Mol.Biol. Baldwin, G.S., Kelly, S.M., Price, N.C., Wilson, G.G., Connolly, B.A., Artymiuk, P.J., and Hornby, D.P.
1994 Organization and sequence of the HpaII restriction-modification system and adjacent genes. Gene Kulakauskas, S., Barsomian, J.M., Lubys, A., Roberts, R.J., and Wilson, G.G.
1994 Molecular Cloning of an Onchocerca volvulus Extracellular Cu-Zn Superoxide Dismutase. Infect.Immun. James, E.R., McLean, D.C.J., and Perler, F.B.
1994 Structure of PvuII endonuclease with cognate DNA. EMBO J. Cheng, X., Balendiran, K., Schildkraut, I., and Anderson, J.E.
1994 Three-dimensional structure of the adenine-specific DNA methyltransferase M.Taq I in complex with the cofactor S-adenosylmethionine. Proc.Natl.Acad.Sci.USA Labahn, J., Granzin, J., Schluckebier, G., Robinson, D.P., Jack, W.E., Schildkraut, I., and Saenger, W.
1994 VISA: Visual Sequence Analysis for the comparison of multiple amino acid sequences. CABIOS Posfai, J., Szaraz, Z., and Roberts, R.J.
1994 Structure of restriction endonuclease BamHI phased at 1.95 A resolution by MAD analysis. Structure Newman, M., Strzelecka, T., Dorner, L.F., Schildkraut, I., and Aggarwal, A.K.
1994 Structure of restriction endonuclease BamHI and its relationship to EcoRI. Nature Newman, M., Strzelecka, T., Dorner, L.F., Schildkraut, I., and Aggarwal, A.K.
1994 The DNA (cytosine-5) methyltransferases. Nucl.Acids Res. Kumar, S., Cheng, X., Klimasauskas, S., Sha, M., Posfai, J., Roberts, R.J., and Wilson, G.G.
1994 Thermal cycle Dideoxy DNA Sequencing. Methods Mol.Biol. Slatko, B.E.
1994 Identification of a new type-II restriction enzyme BsrGI from Bacillus stearothermophilus GR75 Chinese Sci. Bull. Chen, Z.F., Pan, X.S.
1994 The 'endo-blue method' for direct cloning of restriction endonuclease genes in E.coli. Nucl.Acids Res. Fomenkov, A., Xiao, J.P., Dila, D., Raleigh, E., and Xu, S.Y.
1994 The I-CeuI endonuclease: purification and potential role in the evolution of Chlamydomonas group I introns. Eur. J. Biochem Marshall, P., Davis, T.B., Lemieux,C.
1994 Restriction and modification. In: Molecular Biology of Bacteriophage T4 American Society for Microbiology, Washington, D.C. Carlson, K., Raleigh, E.A. and Hattman, S.
1995 Purification and characterization of C.BamHI, a regulator of the BamHI restriction-modification system. Gene Sohail, A., Ives, C.L., and Brooks, J.E.
1995 Protein splicing: Chracterization of the aminosuccinimide residue at the carboxyl terminus of the excised intervening sequence. Biochemistry Shao, Y., Xu, M.Q.and Paulus, H.
1995 Regulation of sCD4-183 gene expression from phage-T7-based vectors in Escherichia coli. Gene Kelley, K.C., Huestis, K.J., Austen, D.A., Sanderson, C.T., Donoghue, M.A., Stickel, S.., Kawasaki, E.S., and Osburne, M.S.
1995 Purification and characterization of novel glycosidases from the bacterial genus Xanthomonas. Glycobiology Wong-Madden, S.T., and Landry, D.
1995 The regulatory C proteins from different restriction-modification systems can cross-complement. J.Bacteriol. Ives, C.L., Sohail, A., and Brooks, J.E.
1995 Structure of BamHI endonuclease bound to DNA: partial folding and unfolding on DNA binding. Science Newman, M., Strzelecka, T., Dorner, L.F., Schildkraut, I., and Aggarwal, A.K.
1995 Typing marine vent thermophiles by DNA polymerase restriction fragement length polymorphisms. Archaea A Laboratory Manual Perler, F.B., Southworth, M.W., Wilbur, D.G., and Wallace, D.
1995 Two novel restriction endonucleases from Campylobacter jejuni. Gene Vitor, J.M., and Morgan, R.D.
1995 Disruption of the target G-C base-pair by the HhaI methyltransferase. Gene Klimasauskas, S., and Roberts, R.J.
1995 Differential recognition of microfilarial chitinase, a transmission-blocking vaccine candidate antigen, by sera from patients with Brigian and Bancroftian filariasis. Am.J.Trop.Med.Hyg. Dissanayake, S., Perler, F.B., Xu, M., Southworth, M.W., Yee, C.K., Wang, S., Dreyer, G., Watawana, L., Kurniawan, L., Fuhrman, J.A., and Piessens, W.F.
1995 Extremozymes: expanding the limits of biocatalysis. Biotechnology Adams, M.W.W., Perler, F.B.and Kelly, R.M.
1995 Identification of recombinant filarial proteins capable of inducing polyclonal and antigen-specific IgE and IgG4 antibodies. J.Immunol. Garraud, O., Nkenfou, C., Bradley, J.E., Perler, F.B., and Nutman, T.B.
1995 Functional analysis of Gln-237 mutants of HhaI methyltransferase. Nucl.Acids Res. Mi, S., Alonso, D., and Roberts, R.J.
1995 Cloning of a gene from Thermus filiformis and characterization of the thermostable nuclease. Gene Fomenkov, A., and Xu, S.Y.
1995 Cloning of a pair of genes encoding isoschizomeric restriction endonucleases from Bacillus species: the BspEI and BspMII restriction and modification systems. Gene Nwankwo, D.O.
1995 Crystal structure of the PvuII restriction endonuclease. Gene Cheng, X., Balendiran, K., Schildkraut, I., and Anderson, J.E.
1995 Crystal structure of endo-beta-N-acetylglucosaminidase H at 1.9 A resolution: active-site geometry and substrate recognition. Structure Rao, V., Guan, C., and Van Roey, P.
1995 Isolation of temperature-sensitive mutants of the BamHI restriction endonuclease. Gene Fomenkov, A., and Xu, S.Y.
1995 Cloning and expression of the NaeI restriction endonuclease-encoding gene and sequence analysis of the NaeI restriction-modification system. Gene Taron, C.H., Van Cott, E.M., Wilson, G.G., Moran, L.S., Slatko, B.E., Hornstra, L.J., Benner, J.S., Kucera, R.B., and Guthrie, E.P.
1995 On the regulation and diversity of restriction in Esherichia coli. Gene Kelleher, J.E., and Raleigh, E.A.
1995 On base flipping. Cell Roberts, R.J.
1995 Orphon spliced-leader sequences form part of a repetitive element in Angiostrongylus cantonensis. Nucl.Acids Res. Joshua, G.W., Perler, F.B., and Wang, C.C.
1995 Photochemically initiated protein splicing. Angew.Chem.Int.Ed.Engl. Cook, S.N., Jack, W.E., Xiong, X., Danley, L.E., Ellman, J.A., Shultz, P.G., and Noren, C.J.
1995 Parasite Cyclophilins and Antiparasite Activity of Cyclosporin A. Parasitology Today Page, A.P., Kumar, S., and Carlow, C.K.S.
1995 M.Hhal binds tightly to substrates containing mismatches at the target base. Nucl.Acids Res. Klimasauskas, S.and Roberts, R.J.
1995 LITMUS: Multipurpose cloning vectors with a novel system for bidirectional in vitro transcription. BioTechniques Evans, P.D., Cook, S.N., Riggs, P.D., and Noren, C.J.
1995 Minimum duplex requirements for restriction enzyme cleavage near the termini of linear DNA fragments. BioTechniques Moreira, R.F., and Noren, C.J.
1995 Nucleotide sequence of a small plasmid isolated from Acetobacter pasteurianus. Gene Fomenkov, A., Xiao, J.P., and Xu, S.Y.
1995 Molecular Characterization of a Cyclosporin A-Insensitive Cyclophilin from the Parasitic Nematode Brugia malayi. Biochemistry Page, A.P., Landry, D., Wilson, G.G., and Carlow, C.K.S.
1995 Active site and oligosaccharide recognition residues of peptide-N4-(N-acetyl-beta-D-glucosaminyl)asparagine amidase F. J.Biol.Chem. Kuhn, P., Guan, C., Cui, T., Tarentino, A.L., Plummer, T.H.J., and Van Roey, P.
1995 A model for DNA binding and enzyme action derived from crystallographic studies of the TaqI N6-adenine-methyltransferase. Gene Schluckebier, G., Labahn, J., Granzin, J., Schildkraut, I., and Saenger, W.
1995 A Promising Recombinant Antigen for the Early Detection of Heartworm Infection. Proceeding of the Heartworm Symposium Hong, X.Q., Mejia, J.S., Nkenfou, C., Perler, F.B., and Carlow, C.K.
1995 A novel beta-galactosidase gene isolated from the bacterium Xanthomonas manihotis exhibits strong homology to several eukaryotic beta-galactosidases. Glycobiology Taron, C.H., Benner, J.S., Hornstra, L.J., and Guthrie, E.P.
1995 CG and CNG methyltransferase in plants Gene Pradhan, S., Houlston, C., Cummings, M., Adams, R.L.P.
1996 The XmnI Restriction-Modification System - Cloning, Expression, Sequence Organization And Similarity Between The R And M-Gene. Gene Nwankwo, D.O., Lynch, J.J., Moran, L.S., Fomenkov, A., and Slatko, B.E.
1996 Genes expressed in Brugia malayi infective third stage larvae. Mol.Biochem.Parasitol. Blaxter, M.L., Raghavan, N., Ghosh, I., Guiliano, D., Lu, W., Williams, S.A., Slatko, B.and Scott, A.L.
1996 Gene cloning and production of active recombinant Brugia Malayi microfilarial chintinase. Gene Southworth, M.W., Fuhrman, J.A., Robbins, P.W., Beauregard, K., and Perler, F.B.
1996 Molecular cloning and expression of NlaIII restriction-modification system in E.coli. Gene Morgan, R.D., Camp, R.R., Wilson, G.G., and Xu, S.Y.