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We believe that basic research and the cultivation of scientific knowledge is critical for us to stay connected with our customers and to drive scientific breakthroughs. At NEB, over 30 labs participate in research projects, which are aided by post-doctoral fellows and students in Masters and Ph.D. programs. NEB researchers have authored or co-authored over 1,000 publications (as of 1/17) many of which are in peer-reviewed journals. Further, NEB products have been used successfully in numerous publications by scientists throughout the world.

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Year Title Journal Authors Application(s)
2018 Core richness of N-glycans of Caenorhabditis elegans: a case study on chemical and enzymatic release Anal. Chem. Yan, S., Vanbeselaere, J., Wöls, F., et. al.
2018 Complete genome sequence and methylome analysis of Bacillus caldolyticus NEB414. Genome Announcements Fomenkov, A., Vincze, T., Mersha, F., Roberts, R.J.
2018 Light-activated chemical probing of nucleobase solvent accessibility inside cells. Nature Chemical Biology Feng, C., Chan, D., Joseph, J., Muuronen, M., Coldren, W.H., Dai, N., Corrêa, I.R., Jr., Furche, F., Hadad, C.M., Spitale, R.C.
2018 Comparative genome and methylome analysis reveals restriction/modification system diversity in the gut commensal Bifidobacterium breve. Nucleic Acids Research Bottacini, F., Morrissey, R., Roberts, R.J., James, J., van Breen, J., Egan, M., Lambert, J., van Limpt, K., Knol, J., O'Connell Motherway, M. and van Sinderen, D.
2018 The non-specific adenine DNA methyltransferase M.EcoGII. Nucleic Acids Res Murray IA
2018 Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity Nat Genet Rošić S
2018 Identification and biosynthesis of thymidine hypermodifications in the genomic DNA of widespread bacterial viruses Proc Natl Acad Sci U S A Lee YJ et al.
2018 A mitochondrial manganese superoxide dismutase involved in innate immunity is essential for the survival of Chlamys farreri Fish Shellfish Immunology Wang M, Wang B, Jiang K, Liu M, Shi X, Wang L.
2018 Host-associated selection of a P3 mutant of zucchini yellow mosaic virus affects viral infectivity in watermelon Archives of Virology Kang B, Peng B, Wu H, Liu L, Wu W, Gu Q.
2018 NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy Genes, Chromosomes, & Cancer Roussy M, Bilodeau M, Jouan L, Tibout P, Laramée L, Lemyre E, Cardin S, Sauvageau C, Couture F, Choblet A, Patey N, Gendron P, Duval M, Teira P, Hébert J, Wilhelm BT, Choi JK, Gruber TA, Bittencourt H, Cellot S.
2018 LytM factor Alr3353 affects filament morphology and cell-cell communication in the multicellular cyanobacterium Anabaena sp. PCC 7120 Molecular Microbiology Bornikoel J, Staiger J, Madlung J, Forchhammer K, Maldener I.
2018 Identification and biosynthesis of thymidine hypermodifications in the genomic DNA of widespread bacterial viruses Proc. Natl. Acad. Sci. Lee, Y.J., Dai, N., Walsh, S.E., Müller, S., Fraser, M.E., Kauffman, K.M., Guan, C., Corrêa, I.R., Jr., Weigele, P.R.
2018 Targeting GLP-1 receptor trafficking to improve agonist efficacy Nat. Commun. 9(1): 1602. doi: 10.1038/s41467-018-03941-2 Jones, B., Buenaventura, T., Kanda, N., Chabosseau, P., Owen, B.M., Scott, R., Goldin, R., Angkathunyakul, N., Corr​êa, I.R., Jr., Bosco, D., Johnson, P.R., Piemonti, L., Marchetti, P., Shapiro, A.M.J., Cochran, B.J., Hanyaloglu, A.C., Inoue, A., Tan, T., Rutter, G.A., Tomas, A., Bloom, S.R.
2018 Complete genome sequence of the freshwater bacterium Beggiatoa leptomitoformis strain D-401 Genome Announcements 6(17): e00311-18. doi: 10.1128/genomeA.00311-18 Fomenkov, A., Sun, Z., Vincze, T. Dubinina, G., Orlova, M., Tarlachkov, S.V., Anton, B.P., Grabovich, M.Y., Roberts, R.J.
2018 Engineering point mutant and epitope-tagged alleles in mice using Cas9 RNA-guided nuclease Current Protocols in Mouse Biology, 8, 28–53. doi:10.1002/cpmo.40. Gertsenstein, M., & Nutter, L. M. J.
2018 The power of synthetic biology for bioproduction, remediation and pollution control. EMBO Reports deLorenzo, V., Prather, K.L.J., Chen, G.-Q., O'Day, E., von Kameke, C., Oyarzun, D.A., Hosta-Rigau, L., Alsafar, H., Cao, C., Ji, W., Okano, H., Roberts, R.J., Ronaghi, M., Yeung, K., Zhang, F., Lee, S.Y.
2018 Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte Nature Hill, P.W.S., Leitch, H.G., Requena, C.E., Sun, Z., Amouroux, R., Roman-Trufero, M., Borkowska, M., Terragni, J., Vaisvila, R., Linnett, S. Bagci, H., Dharmalingham, G., Haberle, V., Lenhard, B., Zheng, Y., Pradhan, S., Hajkova, P.
2017 The advantages of SMRT™ sequencing.  Genome Biology Roberts, R.J., Carneiro, M.O., Schatz, M.C.
2017 ​Colorimetric tests for diagnosis of filarial infection and vector surveillance using non-instrumented nucleic acid loop-mediated isothermal amplification (NINA-LAMP). PLoS One Poole, C.B., Li, Z., Alhassan, A., Guelig, D., Diesburg, S., Tanner, N.A., Zhang, Y., Evans, T.C. Jr., LaBarre, P., Wanji, S., Burton R.A. and Carlow, C.K.
2017 Examining Sources of Error in PCR by Single-Molecule Sequencing. PLoS ONE Potapov Vladamir, Ong Jennifer L
2017 Rapid Time Scale Analysis of T4 DNA Ligase–DNA Binding. Biochemistry Bauer, R.J., Jurkiw, T.J., Evans, T.C. Jr. and Lohman, G.J.
2017 Methods for structural and functional analyses of intramembrane prenyltransferases in the UbiA superfamily Methods Enzymol Yang, Y., Ke, N., Liu, S., Li, W.
2017 Mechanism and timing of Mcm2-7 ring closure during DNA replication origin licensing Nat. Struct. Mol. Biol. Ticau, S., Friedman, L.J., Champasa, K., Correa, I.R., Jr., Gelles, J., Bell, S.P.
2017 Removing the needle from the haystack: Enrichment of Wolbachia endosymbiont transcripts from host rematode RNA by Cappable-seqTM PLoS One Luck, A.N., Slatko, B.E., Foster, J.M.
2017 NicE-seq: High resolution open chromatin profiling Genome Biology Ponnaluri, V.K.C., Zhang, G., Estève, P.-O., Spracklin, G., Sian, S., Xu, S.-Y., Benoukraf, T., Pradhan, S.
2017 High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding PNAS Evan A. Boyle, Johan O.L. Andreasson, Lauren M. Chircus, Samuel H. Sternberg, Michelle J. Wu, Chantal K. Guegler, Jennifer A. Doudna, and William J. Greenleaf
2017 Genome Announce Genome Announce. Fomenkov, A., Akimov, V.N., Vasilyeva, L.V., Andersen, D.T., Vincze, T., Roberts, R.J.
2017 Macrocycle peptides delineate locked-open inhibition mechanism for micoorganism phosphoglycerate mutases Nat. Commun. Yu, H., Dranchak, P., Li, Zhiru, MacArthur, R., Munson, M.S., Mehzabeen, N., Baird, N.J., Battalie, K.P., Ross, D., Lovell, Sc., Carlow, C.K.S., Suga, H., Inglese, J.
2017 Highly specific imaging of mRNA in single cells by target RNA-initiated rolling circle amplification Chem Sci Deng, Ruijie., Zhang, Kaixiang., Sun, Yupeng., Ren, Xiaojun., Li, Jinghong.
2017 The GAN exonuclease, or the flap endonuclease Fen1 and RNase HII are necessary for viability of Thermococcus kodakarensis J. Bacteriol Burkhart, B.W., Cubonova, L., Heider, M.R., Kelman, Z., Reeve, J.N., Santangelo, T.J.
2017 Targeted enrichment and sequencing of recent endosymbiont-host lateral gene transfers Sci Rep. Dunning Hotopp, J.C., Slatko, B.E., Foster, J.M.
2017 Whole genome amplification provides suitable control DNA for use in DNA barcoding applications Biop. Bourque, D.A., Naaum, A.M., Distel, D.L., Hanner, R.H.
2017 Various Mutations compensate for a deleterious lacZα insert in the replication enhancer of M13 bacteriophage PLoS One Zygiel, E.M., Noren, K.A., Adamkiewicz, M.A., Aprile, R.J., Bowditch, H.K., Carroll, C.L., Cerezo, M.A.S., Dagher, A.M., Hebert, C.R., Hebert, L.E., Mahame, G.M., Milne, S.C., Silvestri, K.M., Sutherland, S.E., Sylvia, A.M., Taveira, C.N., VanValkenburgh, D.J., Noren, C.J., Hall, M.F.
2017 Rpn (YhgA-Like) Proteins of Escherichia coli K-12 and their Contribution to Rec-A-Independent Horizontal Transfer J. Bacteriol Kingston, A.W., Ponkratz, C. and Raleigh, E.A.
2017 Restriction endonuclease AgeI is a monomer which dimerizes to cleave DNA Nucleic Acids Res. Tamulaitiene, G., Jovaisaite, V., Tamulaitis, G., Songailiene, I., Manakova, E., Zaremba, M., Grazulis, S., Xu, S.Y., Siksnys, V.
2017 Serotyping dengue virus with isothermal amplification and a portable sequencer Scientific Reports Yamagishi, J., et al.
2017 Sequential formation of two branched intermediates during protein splicing of class three inteins Extrmophiles Tori, K. and Perler, F.
2017 Association of 5-hydroxymethylation and 5-methylation of DNA cytosine with tissue-specific gene expression Epigenetics Ponnaluri, V.K., Ehrlich, K.C., Zhang, G., Lacey, M., Johnston, D., Pradhan, S., Ehrlich, M.
2017 A refined DNA methylation detection method using MspJI coupled quantitative PCR Analytical Biochemistry Petell, C.J., Loiseau, G., Gandy, R., Pradhan, S., Gowher, H.
2017 Complete genome sequence and methylome analysis of Acinetobacter calcoaceticus 65 Fomenkov, A., Vincze, T., Degtyarev, S.K., Roberts, R.J.
2017 Complete genome and methylome sequences of Salmonella enterica subsp. enterica Serovars Typhimurium, Saintpaul, and Stanleyville from the SARA/SARB collection Genome Announce Yao, K., Roberts, R.J., Allard, M.W., Hoffmann, M.
2017 A practical guide to the oral microbiome and its relation to health and disease Krishnan, K., Chen, T., Paster, B.J.
2017 EcoBLMcrX, a classical modification-dependent restriction enzyme in Escherichia coli B: Characterization in vivo and in vitro with a new approach to cleavage site determination PLoS One Fomenkov, A., Sun, Z., Dila, D.K., Anton, B.P., Roberts, R.J., Raleigh, E.A.
2017 Dynamics of 5-carboxylcytosine during hepatic differentiation: potential general role for active demethylation by DNA repair in lineage specification Lewis, L.C., Lo, P.C., Foster, J.M., Dai, N., Correa, I.R., Jr., Durczak, P.M., Duncan, G., Ramsawhook, A., Aithal, G.P., Denning, C., Hannan, N.R., Ruzov, A.
2017 Functional characterisation of cis-regulatory elements governing dynamic Eomes expression Development Simon, C.S. et al.
2017 Evaluating computatonal gene ontology annotations Methods Mol. Biol. Skunca, N., Roberts, R.J., Steffen, M.
2017 DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification Science Chen, L., Liu, P., Evans, T.C., Jr., Ettwiller, L.M.
2017 Defining the RNaseH2 enzyme-initiated ribonucleotide excision repair pathway in Archaea J. Biol Chem. Heider, M.R., Burkhart, B.W., Santangelo, T.J., Gardner, A.F.
2017 DNA target recognition domains in the Type I restriction and modification systems of Staphylococcus aureus Nucl. Acids Res. Cooper, L.P., Roberts, G.A., White, J.H., Luyten, Y.A., Bower, E.K., Morgan, R.D., Roberts, R.J., Lindsay, J.A., Dryden, D.T.
2017 DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target Nucl. Acids Res. Shen, B.W., Heiter, D.F., Lunnen, K.D., Wilson, G.G., Stoddard, B.L.
2017 De novo assembly of genomes from long sequence reads reveals uncharted territories of Propionibacterium freudenreichii BMC Genomics Deptula, P., Laine, P.K., Roberts, R.J., Smolander, O.-P., Vihinen, H., Piironen, V., Paulin, L., Jokitalo, E., Savijoki, K., Auvinen, P., Varmanen, P.
2017 Restriction-modification mediated barriers to exogenous DNA uptake and incorporation employed by Prevotella intermedia Johnston, C.D., Skeete, C.A., Fomenkov, A., Roberts, R.J., Rittling, S.R.
2017 Balancing herbal medicine and functional food for prevention and treatment of cardiometabolic diseases through modulating gut microbiota Front Microbiol Lyu, M., Wang, Y.F., Fan, G.W., Wang, X.Y., Xu, S.Y., Zhu, Y.
2017 Building bridges through science Neuron Lissek, T., Adams, M., Adelman, J.
2017 Examining Sources of Error in PCR by Single-Molecule Sequencing PLOS Vladimir Potapov and Jennifer L. Ong*
2017 Examining Sources of Error in PCR by Single-Molecule Sequencing. PLOS One Vladimir Potapov, Jennifer L. Ong.
2017 Expression and comparative characterization of complete and C-terminally truncated forms of saccharifying a-amylase from Lactobacillus plantarum S21. International Journal of Biological Macromolecules Kanpiengjai A, Nguyen TH, Haltrich D, Khanongnuch C.
2017 Genetic and epigenetic insight into morphospecies in a reef coral. Molecular Ecology James L. Dimond,Sanoosh K. GamblewoodSteven B. Roberts
2017 Isothermal Amplification of Long, Discrete DNA Fragments Facilitated by Single-Stranded Binding Protein Scientific Reports Zhang Y, Tanner N
2017 Ultrasensitive detection of acute myeloid leukemia minimal residual disease using single molecule molecular inversion probes. Hematologica Adam Waalkes, Kelsi Penewit, Brent L. Wood, David Wu, and Stephen J. Salipante
2017 What is in your cup of tea? DNA Verity Test to characterize black and green commercial teas. PLOS One Olga De Castro , Maria Comparone, Antonietta Di Maio, Emanuele Del Guacchio, Bruno Menale, Jacopo Troisi, Francesco Aliberti, Marco Trifuoggi , Marco Guida
2017 First Report of the Soybean Cyst Nematode, Heterodera glycines, in New York X. Wang, G. C. Bergstrom, S. Chen, D. M. Thurston, and J. A. Cummings, and Z. A. Handoo, M. N. Hult, and A. M. Skantar,
2017 Duplex Alu Screening for Degraded DNA of Skeletal Human Remains Diversity
2017 NEBNext Human Microbiome DNA Enrichment Kit Scientific Reports 5. Thomas, T.
2017 Caenorhabditis elegans CES-1 snail represses Pig-1 MELK expression to control asymmetric cell division. Genetics Wei, H., Yan, B., Gagneur, J., Conradt, B.
2017 The gut commensal microbiome of Drosophila melanogaster is modified by the endosymbiont Wolbachia. mSphere Simhardi, R.K., Fast,E.M., Guo, R., Schultz, M.J., Vaisman, N., Ortiz, L., Bybee, J., Slatko, B.E., Frydman, H.M.
2017 Metabolic Incorporation of Azide Functionality into Cellular RNA Chembiochem Nainar S et al.
2017 Dynamics of 5-carboxylcytosine during hepatic differentiation: Potential general role for active demethylation by DNA repair in lineage specification. Epigenetics Lewis LC
2017 Restriction and modification of deoxyarchaeosine (dG+)-containing phage 9 g DNA. Sci Rep Tsai R et al
2017 Fidelity of RNA templated end-joining by chlorella virus DNA ligase and a novel iLock assay with improved direct RNA detection accuracy Nucleic Acids Research Krzywkowski, T., Nilsson M.
2017 Complete genome sequence of Kluyveromyces lactis strain GG799, a common yeast host for heterologous protein expression Genome Announcements Chuzel, L., Ganatra, M.B., Schermerhorn, K.M., Gardner, A.F., Anton, B.P., Taron, C.H.
2017 Using high-throughput barcode sequencing to efficiently map connectomes Nucleic Acids Research Peikon, I.D., Kebschull, J.M., Vagin, V.V., Ravens, D.I, Sun, Y.-C., Brouzes, E., Correa, I.R., Bressan, D., Zador, A.M.
2017 Using high-throughput barcode sequencing to efficiently map connectomes Nucleic Acids Research Peikon, I.D., Kebschull, J.M., Vagin, V.V., Ravens, D.I, Sun, Y.-C., Brouzes, E., Correa, I.R., Bressan, D., Zador, A.M.
2017 Complete genome sequence of Kluyveromyces lactis strain GG799, a common yeast host for heterologous protein expression Genome Announcements Chuzel, L., Ganatra, M.B., Schermerhorn, K.M., Gardner, A.F., Anton, B.P., Taron, C.H.
2016 Visualization of Periplasmic and Cytoplasmic Proteins with a Self-Labeling Protein Tag. J Bacteriol Ke, N., Landgraf, D., Paulsson, J. and Berkmen, M.
2016 Using glycosidases to remove, trim, or modify glycans on therapeutic proteins BioProcess International Guthrie, E.P., Magneilli, P.E.
2016 The Inhibitory Effect of Non-Substrate and Substrate DNA on the Ligation and Self-Adenylylation Reactions Catalyzed by T4 DNA Ligase. PLoS One Bauer, R.J., Evans, T.C. Jr. and Lohman, G.J.
2016 Sensitive Detection of Plasmodium vivax Using a High-Throughput, Colourimetric Loop Mediated Isothermal Amplification (HtLAMP) Platform: A Potential Novel Tool for Malaria Elimination. PLoS Negl Trop Dis Britton, S., Cheng, Q., Grigg, M.J., Poole, C.B., Pasay, C., William, T., Fornace, K., Anstey, N.M., Sutherland, C.J., Drakeley, C. and McCarthy, J.S.
2016 Sensitive and specific miRNA detection method using SplintR LigasePublication. Nucleic Acids Res. Jin, J., Vaud, S., Zhelkovsky, A.M., Posfai, J. and McReynolds, L.A.
2016 The Epigenomic Landscape of Prokaryotes. PLoS Genet. Blow, M.J., Clark, T.A., Daum, C.G., Deutschbauer, A.M., Fomenkov, A., Fries, R., Froula, J., Kang, D.D., Malmstrom, R.R., Morgan, R.D., Posfai, J., Singh, K., Visel, A., Wetmore, K., Zhao, Z., Rubin, E.M., Korlach, J., Pennacchio, L.A. and Roberts, R.J.
2016 Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities. PLoS Biol. Callahan, S.J., Luyten, Y.A., Gupta, Y.K., Wilson, G.G., Roberts, R.J., Morgan, R.D. and Aggarwal, A.K.
2016 Phenotypic and molecular analysis of the effect of 20-hydroxyecdysone on the human filarial parasite Brugia malayi. Int J Parasitol Mhashilkar, A.S., Adapa, S.R., Jiang, R.H., Williams, S.A., Zaky, W., Slatko, B.E., Luck, A.N., Moorhead, A.R. and Unnasch, T.R.
2016 A novel enrichment strategy reveals unprecedented number of novel transcription start sites at single base resolution in a model prokaryote and the gut microbiome. BMC Genomics Ettwiller, L., Buswell, J., Yigit, E. and Schildkraut, I
2016 A mix-and-read drop-based in vitro two-hybrid method for screening high-affinity peptide binders. Sci Rep Cui, N., Zhang, H., Schneider, N., Tao, Y., Asahara, H., Sun, Z., Cai, Y., Koehler, S.A., de Greef, T.F., Abbaspourrad, A., Weitz, D.A. and Chong, S.
2016 Absence of the filarial endosymbiont Wolbachia in seal heartworm (Acanthocheilonema spirocauda) but evidence of ancient lateral gene transfer. J Parasitol. Keroack, C.D., Wurster, J.I., Decker, C.G., Williams, K.M., Slatko, B.E., Foster, J.M. and Williams, S.A.
2016 Comprehensive Profiling of Glycosphingolipid Glycans Using a Novel Broad Specificity Endoglycoceramidase in a High-Throughput Workflow. Albrecht, S., Vainauskas, S., Stöckmann, H., McManus, C., Taron, C.H. and Rudd, P.M.
2016 Complete Genome Sequence of the Engineered Escherichia coli SHuffle Strains and Their Wild-Type Parents Genome Announc. Anton, B.P., Fomenkov, A., Raleigh, E.A. and Berkmen, M.
2016 Genetics: profiling DNA methylation and beyond Nature Methods Marx V. Epigenetics,Restriction Enzymes for Epigenetics
2016 Genetically anchored fluorescent probes for subcellular specific imaging of hydrogen sulfide. Analyst Chen, J., Zhao, M., Jiang, X., Sizovs, A., Wang, M.C., Provost, C.R., Huang, J. and Wang, J.
2016 Complete Genome Sequence of a Strain of Azospirillum thiophilum Isolated from a Sulfide Spring. Genome Announc. Fomenkov, A., Vincze, T., Grabovich, M., Anton, B.P., Dubinina, G., Orlova, M., Belousova, E. and Roberts, R.J.
2016 Characterization of innate immunity genes in the parasitic nematode Brugia malayi Symbiosis Libro, S., Slatko, B.E. and Foster, J.M.
2016 AnnoTALE: bioinformatics tools for identification, annotation, and nomenclature of TALEs from Xanthomonas genomic sequences. Sci Rep. Grau, J., Reschke, M., Erkes, A., Streubel, J., Morgan, R.D., Wilson, G.G., Koebnik, R. and Boch, J.
2016 Complete Genome Sequence and Methylome Analysis of Aeromonas hydrophila Strain YL17, Isolated from a Compost Pile. Genome Announc. Lim, Y.L., Roberts, R.J., Ee, R., Yin, W.F. and Chan, K.G.
2016 Complete Genome and Methylome Sequences of Salmonella enterica subsp. enterica Serovar Panama (ATCC 7378) and Salmonella enterica subsp. enterica Serovar Sloterdijk (ATCC 15791). Genome Announc. Yao, K., Muruvanda, T., Roberts, R.J., Payne, J., Allard, M.W. and Hoffmann, M.
2016 Host-Associated Genomic Features of the Novel Uncultured Intracellular Pathogen Ca. Ichthyocystis Revealed by Direct Sequencing of Epitheliocysts. Genome Biol. Evol. Qi, W. et al.
2016 Epidemiological typing of Neisseria gonorrhoeae and detection of markers associated with antimicrobial resistance directly from urine samples using next generation sequencing Sex. Transm. Infect Graham, R.M.A. et al.
2016 The Microbiome of Aseptically Collected Human Breast Tissue in Benign and Malignant Disease Sci Rep. Hieken, T.J. et al.
2016 omplete Genome Sequence and Methylome Analysis of Bacillus globigii ATCC 49760. Genome Announc. Morgan, R.D.
2016 Metagenomic analysis of bloodstream infections in patients with acute leukemia and therapy induced neutropenia. Sci Rep. Gyarmati, P. et al.
2016 Genomic study of the Ket: a PaleoEskimo-related ethnic group with significant ancient North Eurasian ancestry. Sci Rep. Flegontov, P. et al.