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We believe that basic research and the cultivation of scientific knowledge is critical for us to stay connected with our customers and to drive scientific breakthroughs. At NEB, over 30 labs participate in research projects, which are aided by post-doctoral fellows and students in Masters and Ph.D. programs. NEB researchers have authored or co-authored over 1,000 publications (as of 1/17) many of which are in peer-reviewed journals. Further, NEB products have been used successfully in numerous publications by scientists throughout the world.

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Year Title Journal Authors Application(s)
2010 “Cloning and bioinformatic identification of small RNAs in the filarial nematode,  Brugia malayi”. Mol.Biochem.Parasitol. Poole, C.B.,   Davis, P.J.,  Jin, J.and McReynolds, L.A.
2017 ​Colorimetric tests for diagnosis of filarial infection and vector surveillance using non-instrumented nucleic acid loop-mediated isothermal amplification (NINA-LAMP). PLoS One Poole, C.B., Li, Z., Alhassan, A., Guelig, D., Diesburg, S., Tanner, N.A., Zhang, Y., Evans, T.C. Jr., LaBarre, P., Wanji, S., Burton R.A. and Carlow, C.K.
2003 Zinc Ion Effects on Individual Ssp DnaE Intein Splicing Steps: Regulating Pathway Progression. Biochemistry Nichols, N.M., Benner, J.S., Martin, D.D.and Evans, T.C.Jr.
2001 Zinc Inhibition of Protein trans-Splicing and Identification of Regions Essential for Splicing and Association of a Split Intein. J.Biol.Chem. Ghosh, I., Sun, L.and Xu, M.Q.
2005 Yersinia pestis outer membrane type III secretion protein YscC: expression, purification, characterization, and induction of specific antiserum Protein Expr. Purif. Goodin, J. L., et al.
2011 YaeJ is a novel ribosome-associated protein inEscherichia coli that can hydrolyze peptidyl-tRNA on stalled ribosomes Nucleic Acids Res.  Handa, Y., Inaho, N. and Nameki, N.
1993 Workshop of DNA Probes and PCR for Detection of Filarial Parasies in Vectors Williams, S.A.
2009 Wolbachia lipoprotein stimulates innate and adaptive immunity through toll-like receptors 2 and 6 (TLR2/6) to induce disease manifestations of filariasis. J Biol Chem. Turner, J.D., Langley, R.S., Johnston, K.L., Gentil, K., Ford, L., Wu, B., Graham, M., Sharpley, F., Slatko, B., Pearlman, E.and Taylor, M.J.
1999 Wolbachia genomes and the many faces of symbiosis. Parasitology Today Bandi, C., Slatko, B.and O'Neill, S.L.
2014 Wolbachia endosymbionts and human disease control Mol. Biochem. Parasitol. Slatko, B. E., Luck, A. N., Dobson, S. L. and Foster, J. M.
2014 Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence Genes Dev Hashimoto H, Olanrewaju YO, Zheng Y, Wilson GG, Zhang X, Cheng X
2007 Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes. Science Hotopp, J.C., Clark, M.E., Oliveira, D.C., Foster, J.M., Fischer, P., Torres, M.C., Giebel, J.D., Kumar, N., Ishmael, N., Wang, S., Ingram, J., Nene, R.V., Shepard, J., Tomkins, J., Richards, S., Spiro, D.J., Ghedin, E., Slatko, B., Tettelin, H.and Werren, J.H.
2014 Whole-genome haplotyping using long reads and statistical methods. Nature Biotechnology Kuleshov, K. et al.
2017 Whole genome amplification provides suitable control DNA for use in DNA barcoding applications Biop. Bourque, D.A., Naaum, A.M., Distel, D.L., Hanner, R.H.
2016 WGS for surveillance of antimicrobial resistance: a pilot study to detect the prevalence and mechanism of resistance to azithromycin in a UK population of non-typhoidal Salmonella. J Antimicrob Chemother. Nair, S. et al.
2004 Western blot analysis of Src kinase assays using peptide substrates ligated to a carrier protein. BioTechniques Xu, J., Sun, L., Ghosh, I.and Xu, M.-Q.
waffles
2006 Visualizing receptor trafficking in living PNAS Jacquier V. et al.
2009 Visualizing biochemical activities in living cells Nat Chem Biol Johnsson K.
2016 Visualization of Periplasmic and Cytoplasmic Proteins with a Self-Labeling Protein Tag. J Bacteriol Ke, N., Landgraf, D., Paulsson, J. and Berkmen, M.
2003 Visualization of coupled protein folding and binding in bacteria and purification of the heterodimeric complex. Proc.Natl.Acad.Sci.USA Wang, H.and Chong, S.
2015 Visual detection of isothermal nucleic acid amplification using pH-sensitive dyes. Biotechniques Tanner NA, Zhang Y, Evans TC Jr
2015 Visual detection of isothermal nucleic acid amplification using pH-sensitive dyes Biotechniques Tanner, N.A., Zhang, Y. and Evans, T.C., Jr.
1994 VISA: Visual Sequence Analysis for the comparison of multiple amino acid sequences. CABIOS Posfai, J., Szaraz, Z., and Roberts, R.J.
2015 VirB6 and VirB10 from the Brucella type IV secretion system interact via the N-terminal periplasmic domain of VirB6 FEBS Lett Giraldo A.MV., Mary C., Sivanesan D., Baron C.
2007 Viral oncoproteins target the DNA methyltransferases Oncogene Burgers, W.A., Blanchon, L., Pradhan, S., de Launoit, Y., Kouzarides, T. and Fuks, F.
2007 Viral oncoproteins target the DNA methyltransferases Oncogene Burgers, W.A., Blanchon, L., Pradhan, S., de Launoit, Y., Kouzarides, T., Fuks,F.
2004 Versatile protein biotinylation strategies for potential high-throughput proteomics J Am. Chem. Soc. Lue, R.Y., et al.
1988 Vectors that facilitate the expression and purification of foreign peptides in Escherichia coli by fusion to maltose-binding protein. Gene Guan, C.D., Li, P., Riggs, P.D., and Inouye, H.
2013 Vectors Brenner's Encyclopedia of Genetics Anton, B.P.
2010 Vascular-Targeting Anti-Oxidant Therapy in a Model of Hypertension and Stroke J. Cardiovasc. Pharmacol Greig, J.A. et al.
2017 Various Mutations compensate for a deleterious lacZα insert in the replication enhancer of M13 bacteriophage PLoS One Zygiel, E.M., Noren, K.A., Adamkiewicz, M.A., Aprile, R.J., Bowditch, H.K., Carroll, C.L., Cerezo, M.A.S., Dagher, A.M., Hebert, C.R., Hebert, L.E., Mahame, G.M., Milne, S.C., Silvestri, K.M., Sutherland, S.E., Sylvia, A.M., Taveira, C.N., VanValkenburgh, D.J., Noren, C.J., Hall, M.F.
2008 Variation of acharan sulfate and monosaccharide composition and analysis of neutral N-glycans in African giant snail (Achatina fulica) Glycoconjugate Journal Park, Y., Zhang, Z., Laremore, T.N., Li, B., Sim, J.S., Im, A.R., Ahn, M.Y., Kim, Y.S., Linhardt, R.J., Glycoconj, J.
2014 Validation of microinjection methods for generating knockout mice by CRISPR/Cas-mediated genome engineering Sci Rep Horii T, Arai Y, Yamazaki M, Morita S, Kimura M, Itoh M, Abe Y, Hatada I Gibson Assembly®
1998 Utilizing the C-terminal cleavage activity of a protein splicing element to purify recombinant proteins in a single chromatographic step. Nucl.Acids Res. Chong, S., Montello, G.E., Zhang, A., Cantor, E.J., Liao, W., Xu, M.-Q.and Benner, J.
2009 Using shotgun sequence data to find active restriction enzyme genes Nuc. Acid. Res. Zheng, Y., Posfai, J., Morgan, R. D., Vincze, T., and Roberts, R.J.
2015 Using Next Generation RAD Sequencing to Isolate Multispecies Microsatellites for Pilosocereus (Cactaceae). PLoS One. Bonatelli IA, Carstens BC, Moraes EM.
1992 Using Molecular Biological Techniques to Identify and Study Gene Products Involved in Dirofilarial Immunoprophylaxis. American Heartworm Society Hough, D.M., Awobuluyi, M.E., McReynolds, L.A., Carlow, C.K.S., and Maina, C.V.
2016 Using glycosidases to remove, trim, or modify glycans on therapeutic proteins BioProcess International Guthrie, E.P., Magneilli, P.E.
2009 Using chemical approaches to study selenoproteins-Focus on thioredoxin reductases Biochim. Biophys. Acta. Hondal, R. J.
2011 Using a structural and logics systems approach to infer bHLH-DNA binding specificity determinants Nucleic Acids Res. De Masi, F., Grove, C.A., Vedenko, A., Alibés, A., Gisselbrecht, S.S., Serrano, L., Bulyk, M.L. and Walhout, A.J.
2010 USER friendly DNA recombination (USERec): a simple and flexible near homology-independent method for gene library construction Protein Eng Des Sel Villiers BR, Stein V, Hollfelder F USER™ Cloning
2007 USER friendly DNA engineering and cloning method by uracil excision Nucl.Acids.Res. Bitinaite, J., Rubino, M., Varma, K.H., Schildkraut, I., Vaisvila, R.and Vaiskunaite, R.
2016 Use of the Shuffle Strains in Production of Proteins. Curr Protoc Protein Sci. Ren, G., Ke, N. and Berkmen, M.
2009 Use of intein-mediated protein ligation strategies for the fabrication of functional protein arrays Methods Enzymol. Chattopadhaya, S., et al.
2007 Use of intein-mediated phosphoprotein arrays to study substrate specificity of protein phosphatases. BioTechniques Kochinyan, S., Sun.L., Ghosh, I., Barshevsky, T., Xu, J.and Xu, M.Q.
2007 Use of intein-mediated phosphoprotein arrays to study substrate specificity of protein phosphatases Biotechniques Kochinyan, S., et al.
1989 Use of Degenerate Oligonucleotides for Amplification of the nifH Gene from the Marine Cyanobacterium Trichodesmium thiebautii. Appl.Environ.Microbiol., Zehr, J.P., and McReynolds, L.A.
2011 Uptake of radiolabeled GlcNAc into Saccharomyces cerevisiae via native hexose transporters and its in vivo incorporation into GPI precursors in cells expressing heterologous GlcNAc kinase. REMS Yeast Res Scarcelli, J.J., Colussi, P.A., Fabre, A.L., Boles, E., Orlean, P.and Taron, C.H.
2012 Uptake of radiolabeled GIcNAc into Saccharomyces cerevisiae via native hexose transporters and its in vivo incorporation into GPI precursors in cells expressing heterologous GIcNAc kinase FEMS Yeast Res Scarcelli, J.J., Colussi, P.A., Fabre, A.L., Boles, E., Orlean, P., Taron, C.H.
2015 Upregulation of glycans containing 3' fucose in a subset of pancreatic cancers uncovered using fusion-tagged lectins. J Proteome Res Singh S., Kuntal P., Yadav J., Tang H., Partyka K., Kletter D., Hsueh P., Ensink E., Kc B., Hostetter G., Xu E.H., Bern M., Smith D.F., Mehta A.S., Brand R., Melcher K., Haab B.B.
2010 Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI.Structure Shen, B.W., Heiter, D.F., Chan, S.H., Wang, H., Xu, S.Y., Morgan, R.D., Wilson, G.G.and Stoddard, B.L.
2010 Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI Structure Shen, B.W., Heiter, D.F., Chan, S.H., Wang, H., Xu, S.Y., Morgan, R.D., Wilson, G.G. and Stoddard, B.L.
2000 Understanding the immutability of restriction enzymes: crystal structure of BglII and its DNA substrate at 1.5 angstrom resolution. Nature Struct.Biol. Lukacs, C.M., Kucera, R., Schildkraut, I.and Aggarwal, A.K.
2007 Uncoupling metallonuclease metal ion binding sites via nudge mutagenesis. J Biol Inorg Chem Papadakos, G.A., Nastri, H., Riggs, P.and Dupureur, C.M.
2007 UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells. Science Bostick, M., Kim, J.K., Esteve, P-O., Clark, A., Pradhan, S and Jacobsen, S.
2009 UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. Nucl.Acids.Res. Kim, J.K., Estève, P.O., Jacobsen, S.E.and Pradhan, S.
2014 Ubiquity and diversity of human-associated demodex mites. PLoS One Megan S Thoemmes, Daniel J Fergus, Julie Urban, Michelle Trautwein, Robert R Dunn Routine PCR
1995 Typing marine vent thermophiles by DNA polymerase restriction fragement length polymorphisms. Archaea A Laboratory Manual Perler, F.B., Southworth, M.W., Wilbur, D.G., and Wallace, D.
1988 Type II restriction-modification systems. Trends in Genetics Wilson, G.G.
2014 Type II restriction endonucleases-a historical perspective and more Nucleic Acids Res Pingoud A, Wilson GG, Wende W
2016 Type II restriction endonucleases - a historical perspective and more. Nucleic Acids Res Pingoud, A., Wilson, G.G. and Wende, W.
1993 Type II Restriction Endonucleases Nucleases Roberts, R.J.and Halford, S.E.
2014 Type II Cadherins Guide Assembly of a Direction-Selective Retinal Circuit. Cell Xin Duan, Arjun Krishnaswamy, Irina De la Huerta, Joshua R Sanes High-Fidelity PCR
2014 Type I restriction enzymes and their relatives Nucleic Acids Res Loenen WA, Dryden DT, Raleigh EA, Wilson GG
2014 Type I restriction enzymes and their relatives Nucleic Acids Research Wil A. M. Loenen, David T. F. Dryden, Elisabeth A. Raleigh, Geoffrey G. Wilson
2008 Two-dimensional gel-based approaches for the assessment of N-Linked and O-GlcNAc glycosylation in human and simian immunodeficiency viruses Proteomics Graham, D.R., Mitsak, M.J., Elliott, S.T., Chen, D., Whelan, S.A., Hart, G.W., Van Eyk, J.E. Glycobiology
1986 Two unique restriction endonucleases from Neisseria lactamica. Nucl.Acids Res. Qiang, B.Q., and Schildkraut, I.
1995 Two novel restriction endonucleases from Campylobacter jejuni. Gene Vitor, J.M., and Morgan, R.D.
2013 Two new restriction endonucleases from Proteus vulgaris. Nucl.Acids Res. Gingeras, T.R., Greenough, L., Schildkraut, I., and Roberts, R.J.
1981 Two new restriction endonucleases from Proteus vulgaris. Nucl.Acids Res. Gingeras, T.R., Greenough, L., Schildkraut, I., and Roberts, R.J.
2015 Two new phragmotic ant species from Africa: morphology and next-generation sequencing solve a caste association problem in the genus Carebara Westwood. Zookeys. Fischer G, Azorsa F, Garcia FH, Mikheyev AS, Economo EP.
2005 Two crystal forms of the restriction enzyme MspI-DNA complex show the same novel structure. Protein Sci. Xu, Q.S., Robert, R.J.and Guo, H.-C.
2011 Two Color STED microscopy in living cells. Biomedical Optics Express Pellett, P.A., Sun, X., Gould, T.J., Rothman, J.E., Xu, M-Q, Corrêa, I.R.Jr.and Bewersdorf, J.
2014 Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes J Cell Sci Arakel EC, Brandenburg S, Uchida K, Zhang H, Lin YW, Kohl T, Schrul B, Sulkin MS, Efimov IR, Nichols CG, Lehnart SE, Schwappach B Glycobiology
2009 Tuning microbial hosts for membrane protein production Microbial Cell Factories Freigassner, M., Pichler, H. and Glieder, A.
2008 Tuning Escherichia coli for membrane protein overexpression PNAS Wagner, S., Klepsch, M., Schlegel, S., Appel, A., Draheim, R., Tarry, M., Hö, M., van Wijk, K.J., Slotboom, D.J., Persson, J.O. and de Gier, J.
2011 Tuning different expression parameters to achieve soluble recombinant proteins in E. coli: Advantages of high-throughput screening Biotechnology Journal Correa, A. and Oppezzo, P.
2011 Tuned Escherichia coli as a host for the expression of disulfide-rich proteins Biotechnology Journal Salinas, G., Pellizza, L., Margenat, M., et al.
2006 TspMI, a thermostable isoschizomer of XmaI (5'C/CCGGG3'): characterization and single molecule imaging with DNA. Appl Microbiol.Biotechnol. Parashar, V., Capalash, N., Xu, S.Y., Sako, Y.and Sharma, P.
2014 Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networks Nucleic Acids Res Singh A, Minia I, Droll D, Fadda A, Clayton C, Erben E
2010 Triplet imaging of oxygen consumption during the contraction of a single smooth muscle cell Biophys. J. Geissbuehler M. et al.
2011 TrbB from conjugative plasmid F is a structurally distinct disulfide isomerase that requires DsbD for redox state maintenance. J Bacteriol Hemmis, C.W., Berkmen, M., Eser, M.and Schildbach, J.F.
2004 Transposon-mediated linker insertion scanning mutagenesis of the Escherichia coli McrA endonuclease. J.Bacteriol. Anton, B.P.and Raleigh, E.A.
1992 Transmission-blocking antibodies recognize microfilarial chitinase in brugian lymphatic filariasis. Proc.Natl.Acad.Sci.USA Fuhrman, J.A., Lane, W.S., Smith, R.F., Piessens, W.F., and Perler, F.B.
2010 Transmembrane delivery and biological effect of human growth hormone via a phage displayed peptide in vivo and in vitro J. Pharm. Sci. Zhang, T. et al.
2015 Transition in sexual system and sex chromosome evolution in the tadpole shrimp Triops cancriformis. Heredity (Edinb). Mathers TC, Hammond RL, Jenner RA, Hänfling B, Atkins J, Gómez A.
2014 Transient accumulation of 5-carboxylcytosine indicates involvement of active demethylation in lineage specification of neural stem cells Cell Rep Wheldon LM, Abakir A, Ferjentsik Z, Dudnakova T, Strohbuecker S, Christie D, Dai N, Guan S, Foster JM, Corrêa IR Jr, Loose M, Dixon JE, Sottile V, Johnson AD, Ruzov A
2014 Transcriptomic analysis of carboxylic acid challenge in Escherichia coli: beyond membrane damage PLoS One Royce LA, Boggess E, Fu Y, Liu P, Shanks JV, Dickerson J, Jarboe LR Gibson Assembly®
2015 Transcriptional Analysis of Deinococcus radiodurans Reveals Novel Small RNAs That Are Differentially Expressed under Ionizing Radiation. Appl. Environ. Microbiol. Tsai, H.C. et al
2016 Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression. Oncotarget Chin, H.G., Ponnaluri, C., Zhang, G., Esteve, P., Schaus, S.E., Hansen, U. and Pradhan, S.
2015 Trans-Pacific RAD-Seq population genomics confirms introgressive hybridization in Eastern Pacific Pocillopora corals. Mol Phylogenet Evol. Combosch DJ, Vollmer SV.
2016 Training the Next Generation of Biomedical Investigators in Glycosciences. J. Clin. Invest. Agre, P., Bertozzi, C., Bissell, M., Campbell, K., Cummings, R., Desai, U., Estes, M., Flotte, T., Fogleman, G.,Gage, F., Ginsburg, D., Gordon, J.I., Hart, G., Hascall, V., Kiessling, L., Kornfeld, S., Lowe, J., Magnani, J., Mahal, L.K., Medzhitov, R., Roberts, R., Sackstein, R., Sarkar, R., Schnaar, R., Schwartz, N., Varki, A., Walt, D., Weissman, I.
2007 Tracking of human Y receptors in living cells- A fluorescence approach Peptides Böhme. et al.
2014 Traceless splicing enabled by substrate induced activation of the Nostoc punctiforme Npu DnaE intein after mutation of a catalytic cystein to serine J Mol Biol. Cheriyan, M., Chan, S-H., Perler, F.
2002 Towards the generation of artificial O6-alkylguanine-DNA alkyltransferases: in vitro selection of antibodies with reactive cysteine residues ChemBioChem Damoiseaux, R. et al
2009 Topological studies of hSVCT1, the human sodium-dependent vitamin C transporter and the influence of N-glycosylation on its intracellular targeting Exp. Cell Res. Velho, A.M., Jarvis, S.M. Glycobiology
2015 TonEBP modulates the protective effect of taurine in ischemia-induced cytotoxicity in cardiomyocytes Cell Death Dis. Yang YJ, Han YY, Chen K, Zhang Y, Liu X, Li S, Wang KQ, Ge JB, Liu W, Zuo J.
2015 Tissue-specific transcriptomics and proteomics of a filarial nematode and its Wolbachia endosymbiont BMC Genomics Luck, A.N., Anderson, K.G., McClung, C.M., VerBerkmoes, N.C., Foster, J.M., Michalski, M.L. and Slatko, B.E. Library Preparation for Next Generation Sequencing
2015 Tissue-specific epigenetics in gene neighborhoods: myogenic transcription factor genes Hum Mol Genet Chandra, S., Terragni, J., Zhang, G., Pradhan, S., Haushka, S., Johnston, D., Baribault, C., Lacey, M. and Ehrlich, M.