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We believe that basic research and the cultivation of scientific knowledge is critical for us to stay connected with our customers and to drive scientific breakthroughs. At NEB, over 30 labs participate in research projects, which are aided by post-doctoral fellows and students in Masters and Ph.D. programs. NEB researchers have authored or co-authored over 1,200 publications (as of 1/19) many of which are in peer-reviewed journals. Further, NEB products have been used successfully in numerous publications by scientists throughout the world.

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Year Title Journal Authors Application(s)
1996 Protein splicing involving the Saccharomyces cerevisiae VMA intein.The steps in the splicing pathway, side reactions leading to protein cleavage, and establishment of an in vitro splicing system. J.Biol.Chem. Chong, S., Shao, Y., Paulus, H., Benner, J., Perler, F.B., and Xu, M.Q.
1998 Utilizing the C-terminal cleavage activity of a protein splicing element to purify recombinant proteins in a single chromatographic step. Nucl.Acids Res. Chong, S., Montello, G.E., Zhang, A., Cantor, E.J., Liao, W., Xu, M.-Q.and Benner, J.
1997 Single-column purification of free recombinant proteins using a self-cleavable affinity tag derived from a protein splicing element. Gene Chong, S., Mersha, F.B., Comb, D.G., Scott, M.E., Landry, D., Vence, L.M., Perler, F.B., Benner, J., Kucera, R.B., Hirvonen, C.A., Pelletier, J.J., Paulus, H., and Xu, M.Q.
1997 Protein Splicing of the Saccharomyces cerevisiae VMA Intein without the Endonuclease Motifs*. J Biol.Chem. Chong, S., and Xu, M.Q.
2014 Overview of cell-free protein synthesis: historic landmarks, commercial systems, and expanding applications Curr Protoc Mol Biol Chong S
2013 Biochemical Characterization of Hypothetical Proteins from Helicobacter pylori. PLOS ONE Choi HP, Juarez S, Ciordia S, Fernandez M, Bargiela R, Albar JP, Mazumdar V, Anton BP, Kasif S, Ferrer M, Steffen M.
2014 Neurospora crassa Female Development Requires the PACC and Other Signal Transduction Pathways, Transcription Factors, Chromatin Remodeling, Cell-To-Cell Fusion, and Autophagy PLoS One Chinnici JL, Fu C, Caccamise LM, Arnold JW, Free SJ Gibson Assembly®
2005 Sequence Specificity and Role of Proximal Amino Acids of the Histone H3 Tail on Catalysis of Murine G9a Lysine 9 Histone H3 Methyltransferase. Biochemistry Chin, H.G., Pradhan, M., Esteve, P., Patnaik, D., Evans, T.C.Jr.and Pradhan, S.
2016 Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression. Oncotarget Chin, H.G., Ponnaluri, C., Zhang, G., Esteve, P., Schaus, S.E., Hansen, U. and Pradhan, S.
2006 Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis. Biochemistry Chin, H.G., Patnaik, D., Esteve, P.O., Jacobsen, S.E.and Pradhan.S.