We believe that basic research and the cultivation of scientific knowledge is critical for us to stay connected with our customers and to drive scientific breakthroughs. At NEB, over 30 labs participate in research projects, which are aided by post-doctoral fellows and students in Masters and Ph.D. programs. NEB researchers have authored or co-authored over 1,000 publications (as of 1/17) many of which are in peer-reviewed journals. Further, NEB products have been used successfully in numerous publications by scientists throughout the world.

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    Basic Research

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Year Title Journal Authors Application(s)
2008 The symbiotic relationship between filarial parasitic nematodes and their wolbachia endosymbionts - a resource for a new generation of control measures. Symbiosis Ghedin, E., Daehnel, K., Foster, J., Slatko, B.and Lustigman S.
2001 Restriction enzyme BsoBI-DNA complex: a tunnel for recognition of degenerate DNA sequences and potential histidine catalysis. Structure van der Woerd, M.J., Pelletier, J.J., Xu, S.and Friedman, A.M.
2003 A Dual Role for an Aspartic Acid in Glycosylasparaginase Autoproteolysis. Structure Qian, X., Guan, C.and Guo, H.-C.
2002 Structure of a tRNA Repair Enzyme and Molecular Biology Workhorse: T4 Polynucleotide Kinase. Structure Galburt, E.A., Pelletier, J., Wilson, G.and Stoddard, B.L.
2004 An asymmetric complex of restriction endonuclease MspI on its palindromic DNA recognition site. Structure Xu, Q.S., Kucera, R.B., Roberts, R.J.and Guo, H.-C.
2005 Implications for Switching Restriction Enzyme Specificities from the Structure of BstYI Bound to a BglII DNA Sequence Structure Townson, S.A., Samuelson, J.C., Xu, S.Y.and Aggarwal, A.K.
2005 Crystal structure of the restriction-modification system control element C.BclI and mapping of its binding site. Structure Sawaya, M.R., Zhu, Z., Fana, M., Chan, S.H., Dabur, R., Xu, S.Y.and Balendiran, G.K.
1995 Crystal structure of endo-beta-N-acetylglucosaminidase H at 1.9 A resolution: active-site geometry and substrate recognition. Structure Rao, V., Guan, C., and Van Roey, P.
1994 Structure of restriction endonuclease BamHI phased at 1.95 A resolution by MAD analysis. Structure Newman, M., Strzelecka, T., Dorner, L.F., Schildkraut, I., and Aggarwal, A.K.
2010 Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI Structure Shen, B.W., Heiter, D.F., Chan, S.H., Wang, H., Xu, S.Y., Morgan, R.D., Wilson, G.G. and Stoddard, B.L.