Thermococcus live in extreme environments exposing DNA to constant damage, which threatens genome integrity. While DNA repair has been extensively studied in bacterial and eukaryotic systems, less is known about archaeal DNA repair. Our research aims to understand how Archaea repairs DNA damage via base excision repair (BER), nucleotide excision repair (NER), mismatch repair and the coupling of replication and repair.
A hot spring in Yellowstone National Park is home to organisms that thrive extreme temperatures and pH. We aim to understand how these organisms cope with DNA damage and maintain intact genomes.