Abl Protein Tyrosine Kinase (Abl)

  • This product was discontinued on 01/01/2013
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Ordering Information

P6050
  • Discontinued
    Discontinued
  • Product Information
    Abl Protein Tyrosine Kinase (AbI) is a truncated form of the v-AbI Protein Tyrosine Kinase, a partner in the Gag-Abl fusion protein of the Abelson murine leukemia virus. Abl contains 407 amino acids (residues 237-643 of the p120-gag-abl polyprotein), which include the kinase catalytic domain, SH2 domain on the N-terminus and the I237M mutation. This truncated form of v-Abl is identical to the normal c-Abl (1-3). Abl is autophosphorylated on tyrosine(s)(2). 

    Highlights

    • Protein tyrosine kinase
    • Abelson Murine Leukemia Virus, recombinant (E. coli)

    Product Source

    Isolated from a strain of E. coli that carries the truncated AbI Protein Kinase encoded by the Abelson murine leukemia virus under the control of a T7 expression system (kindly provided by Dr. S. Goff).

    Recognition Determinant

    The recognition motif for phosphorylation by Abl is I/V/LYXXP/F. Abl, like many cytosolic protein tyrosine kinases, preferentially phosphorylates sites recognized by its own SH2 domain, selects substrates with large hydrophobic amino acids at the +3 position and β-branched amino acids at the -1 position (4).

    Reagents Supplied

    The following reagents are supplied with this product:

    Store at (°C) Concentration
    NEBuffer™ for Protein Kinases (PK) -20 10 X
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