Plasmodium falciparum chitinase (PfCHT1)
- This product was discontinued on January 01, 2013
Plasmodium falciparum chitinase (PfCHT1) is thought to have a role in parasite transmission by acting on the chitin-containing peritrophic membrane of the mosquito vector's bloodmeal to release the ookinetes (1, 2). Inhibition of chitinase activity in the mosquito midgut with allosamidin, a chitinase inhibitor, blocks parasitic transmission (3).
Product SourceIsolated from E. coli cells carrying a plasmid with the PfCHT1 gene cloned from Plasmodium falciparum (kindly provided by J. Vinetz) (1).
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