Brugia malayi chitinase (BmCHT1)
- This product was discontinued on January 01, 2013
Brugia malayi chitinase (BmCHT1) is expressed in the microfilarial stage, the first larval stage, of the organism and is thought to be important in the exsheathment process of the microfilaria (1). Exsheathment is required for further development of the microfilaria once ingested by the mosquito vector (2). The microfiliaria of Brugia malayi have been shown to have chitin in their sheaths (3). Antisera to the chitinase temporarily cleared the microfilaria from the bloodstream of infected jirds (1,4).
Product SourceIsolated from the supernatant of Spodoptera frugiperda (Sf9) insect cells infected with an AcNPV chiA minus recombinant baculovirus carrying the BmCHT1 gene cloned from Brugia malayi (kindly provided by J. Fuhrman) (1).
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