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hNEIL1

  • This product was discontinued on July 02, 2012
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Ordering Information

M0335
  • Discontinued
    Discontinued
  • Product Information
    Human NEIL1 acts as both an N-glycosylase and an AP-lyase. The N-glycosylase activity releases oxidized pyrimidines and purines from double-stranded DNA, generating an apurinic (AP site). The AP-lyase activity cleaves 3´ and 5´ to the AP site leaving a 5´ phosphate and a 3´ phosphate. Damaged bases recognized and removed by hNEIL1 include thymine glycol, 5,6-dihydrothymine, 5,6-dihydroxyuracil, 5-hydroxycytosine, 5-hydroxyuracil, 5-formyluracil, 8oxo-guanine opposite C, T or G, 4,6-diamino-5-formamidopyrimidine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (1,2).

    Product Source

    An E. coli strain that carries the cloned human NEIL1 gene.

    Reagents Supplied

    The following reagents are supplied with this product:

    Store at (°C) Concentration
    Endonuclease VIII Reaction Buffer -20 10 X
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