G9a Methyltransferase methylates lysine 9 (Lys 9) of histone H3 (1-3). Methylation occurs at the ε amino group of lysine residues. Methylation of histone H3 Lys 9 is a hallmark of silent chromatin and is globally distributed throughout the heterochromatic regions, such as centromeres and telomeres (4,5).
Product SourceG9a enzyme is expressed from mouse G9a cDNA using an E. coli GST fusion expression system.
The following reagents are supplied with this product:
Store at (°C) Concentration HMT Reaction Buffer 10X S-adenosylmethionine (SAM) -20 32 mM
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