Human PRMT1 Methyltransferase
- This product was discontinued on January 02, 2018
PRMT1 is a major protein arginine methyltransferase (1). It specifically methylates arginine 3 (Arg 3) of H4 in vitro and in vivo. Methylation of histone H4 at Arg 3 facilitates transcriptional activation by nuclear hormone receptor (2).
- Supplied with 10x HMT Buffer and 32 mM S-adenosylmethionine (SAM)
Ordered cooperative functions of PRMT1, p300 and CARM1 in transcriptional activation by p53 is observed on the GADD45 gene following ectopic p53 expression and/or UV irradiation (3).
Product SourcePRMT1 enzyme is expressed from human PRMT1 cDNA using an MBP fusion tag expressed in E. coli.
The following reagents are supplied with this product:
Store at (°C) Concentration HMT Reaction Buffer -20 10 X S-adenosylmethionine (SAM) -20 32 mM
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