NEB offers a selection of DNA and protein methyltransferases. DNA methyltransferases transfer a methyl group from S-adenosylmethionine to either adenine or cytosine residues and can be used to generate methylated DNA at specific sites for gene expression studies. Our selection includes CpG methyltransferase (NEB #M0226), which transfers a methyl group to the C5 position of cytosine residues and is especially useful for studying CpG methylation effects. Several protein methyltransferases are also available for the specific methylation of lysine and arginine residues in Histone H3 and H4 for gene regulation studies.
