NEBinspired Blog

Cell-free DNA Synthesis for a Faster Path to RNA and DNA Therapeutics

Tue, 24 Mar 2026 00:00:00 Z

Cell-free dbDNA provides a fast, enzymatic method for producing high-quality DNA without bacterial fermentation. By simplifying workflows and reducing impurities, it shortens development timelines and accelerates RNA and DNA therapeutic programs from design to clinic.

8 tips to Follow When Choosing a Restriction Enzyme for In vitro mRNA Transcription for Vaccine and Therapeutics Production

Tue, 17 Mar 2026 00:00:00 Z

Originally published in 2021; updated in March 2026

Choosing the right restriction enzyme is a critical first step in in vitro transcription for mRNA vaccine and therapeutic production. This post discusses key factors that influence enzyme choice and explains how careful selection supports efficient IVT, reduces unwanted by‑products, and enables scalable, compliance‑ready mRNA manufacturing.

A Universal PCR Annealing Temperature Means Balancing Convenience with Specificity

Wed, 25 Feb 2026 00:00:00 Z

Annealing temperature is a critical parameter that can determine PCR specificity and yield. Some workflows benefit from a single thermocycling protocol across numerous primer sets. NEB scientists evaluated the benefits and limitations of using a universal annealing temperature to achieve robust amplification across diverse targets.

What to Do After Your Life Science Degree: Post-baccalaureate and Post-doctoral Programs

Wed, 14 Jan 2026 00:00:00 Z

How do you decide what to do after graduation? This blog post outlines what postbacs, postdocs and internships are, and how the training can help launch a career in life science.

Building Genes Faster and Cheaper with Decentralized Workflows

Wed, 19 Nov 2025 00:00:00 Z

Read about a new decentralized workflow from NEB researchers that’s redefining how scientists synthesize genes. By combining data-optimized design with advanced assembly techniques, this approach delivers sequence-verified constructs in as little as four days—at a fraction of the traditional cost. With faster turnaround, higher fidelity, and fewer external dependencies, this workflow enables researchers to conduct complex gene synthesis projects more efficiently and at greater scale, supporting broader access to advanced synthetic biology methods.

Unlocking the Power of DNA Repair Enzymes in Molecular Biology Workflows

Wed, 22 Oct 2025 00:00:00 Z

Learn how DNA modifications can serve as a springboard to develop molecular workflows, using our technical recommendations and resources.

Advancing DNA Barcoding at the Royal Botanic Garden Edinburgh

Thu, 25 Sep 2025 00:00:00 Z

Metabarcoding can take a panoramic view of biodiversity from complex environmental DNA samples and accurately inform us about individual species. Learn how Nattanon Meeprom, Ph.D., surmounted sample challenges to accelerate data collection as part of a research team evaluating Saudi Arabian ecosystems.

Design, Assemble and Express with Confidence: Enabling High-throughput DNA Assembly and Protein Expression Workflows

Mon, 25 Aug 2025 00:00:00 Z

Cell-free protein synthesis (CFPS) can permit workflow time savings and high throughput, while avoiding several limitations associated with in vivo protein expression systems. Learn more about how you can go from design to protein purification in less time with more throughout in this blog post.

mRNA Synthesis Democratized with Open-source Approach by BASE Facility Researchers

Tue, 29 Jul 2025 00:00:00 Z

In this blog post, New England Biolabs Sales Manager of Australia & New Zealand, Jenny Brown, interviews Timothy Mercer, Professor at the University of Queensland and Director of the BASE facility and Seth Cheetham, Associate Professor at the University of Queensland and Deputy Director of the BASE facility. The two recently published a novel protocol for mRNA synthesis in Nature Protocols utilizing standard laboratory techniques and equipment to produce high-purity mRNA suitable for in vitro and in vivo preclinical studies.

How Lyophilized Beads Are Changing Diagnostics and Research

Sun, 22 Jun 2025 00:00:00 Z

In this blog post, learn how lyophilized beads are reshaping diagnostics and research by providing a stable, ready-to-use reagent format that overcomes cold-chain and handling challenges while streamlining workflows. Through optimized freeze-drying processes and automation-friendly design, these ambient-stable beads ensure robust assay performance and decreased hands-on time. NEB Lyo Sciences’ expertise in freeze-dry protocols and custom solutions empowers both laboratory research and field-based testing.

Redefining NGS Library Prep for the Real World: Streamlining for Speed and Savings

Mon, 12 May 2025 00:00:00 Z

In today’s high-demand genomics landscape, researchers need library prep solutions that can keep pace. At the University of Michigan’s Advanced Genomics Core, Director Dr. Olivia Koues shares how her team streamlined operations, improved turnaround times, and handled diverse, challenging samples using the NEBNext UltraExpress® Library Prep Kits.

Conserving Resources in Life Science

Tue, 22 Apr 2025 00:00:00 Z

Watch the opening talk on climate change at our Go Green Symposium and learn how NEB contributes to conserving resources in life science and protecting nature. Listen to a bioacoustics recording from our campus conservation land.

Engaging with Sustainability Through a Green Fair

Tue, 15 Apr 2025 00:00:00 Z

Sustainability comes in many forms, from direct environmental issues to economic, educational, and social concerns. To highlight the many facets, the NEB community hosted a Green Fair with over 30 organizations that benefit their communities. Considering hosting your own Green Fair? Learn more about how our Green Fair promoted relationships with local green organizations to support change, and view some tips for making your Fair a success.

OSA Conservation is Connecting Habitats to Create Climate Resilience for People and Nature in Costa Rica

Tue, 08 Apr 2025 00:00:00 Z

This Earth Month, hear about how Osa Conservation’s Ridge to Reef initiative is actively preserving critical ecosystems and advancing community-driven conservation. Learn more about their achievements and how these efforts are making a difference.

Essential Tips for PCR & DNA Cleanup: Maximize Your DNA Purity and Yield

Mon, 10 Mar 2025 00:00:00 Z

Learn expert techniques for PCR and DNA cleanup to enhance DNA purity and yield. This guide outlines key steps—binding, washing, and eluting—with practical dos and don'ts for each phase. Learn how the Monarch Spin PCR & DNA Cleanup Kit can optimize your molecular biology workflows, ensuring high-quality results for your downstream applications.

Beyond the NEB Catalog -
Over 40 Years of Supporting Customers with Customized Solutions

Tue, 11 Feb 2025 00:00:00 Z

For over 40 years, NEB has provided scientists with high-quality reagents and customized solutions. We offer larger quantities of catalog products, custom formulations and packaging, and lyophilization to meet unique needs. Our collaborative approach and commitment to sustainability make us a trusted partner in advancing molecular biology research.

Melding Scientific and Artistic Creativity

Wed, 29 Jan 2025 00:00:00 Z

The four 2024 Passion in Science Arts and Creativity Awardees combine scientific and artistic creativity to innovate scientific expression. In this blog, we showcase their art and the meanings and processes behind their pieces.

Imbuing Science with Compassion

Wed, 22 Jan 2025 00:00:00 Z

The two Humanitarian Duty Award recipients for the 2024 Passion in Science Awards showcase the power of science to improve lives. Read more about their efforts to improve health outcomes in Nigeria and Ethiopia in this blog.

Promoting More Sustainable Science

Wed, 15 Jan 2025 00:00:00 Z

The two Environmental Stewardship Award recipients for the 2024 Passion in Science Awards inspire greener lab practices through their work and resources. Read about how they are promoting more sustainable science in this blog.

Shaping Scientific Access and Equality

Wed, 08 Jan 2025 00:00:00 Z

The five Scientific Mentorship and Advocacy Award recipients for the 2024 Passion in Science Awards spark scientific inspiration and education through their efforts. Read about their work to shape the future of science in this blog.

Getting Started with Golden Gate Assembly

Mon, 16 Dec 2024 00:00:00 Z

Golden Gate Assembly is a versatile, one-step cloning method frequently used for the modular and hierarchical assembly of DNA into large constructs. This article aims to demystify Golden Gate, explains when and how to use it, and gives you everything you need to add this valuable method to your molecular biology toolbox.

Afrigen's Mission to Empower Developing Countries with mRNA Vaccine Production

Sun, 10 Nov 2024 00:00:00 Z

Read about how Afrigen Biologics, supported by the WHO, are addressing global vaccine inequity by empowering developing countries with mRNA vaccine production capabilities. Through local manufacturing initiatives and extensive training, Afrigen is fostering sustainable vaccine development to address regional health needs and improve global health security.

Choosing the Best Exonuclease for Your Workflow

Tue, 29 Oct 2024 00:00:00 Z

Selecting the exonuclease that meets your application needs is easier with NEB’s technical insight and user-friendly selection tools. Drawing from our long history in enzymology and solutions for basic research and applied scientific development, we’re sharing answers to some common questions about exonucleases and providing the resources you can use for successful exonuclease selection.

Why Glycerol-free Reagents Matter in Molecular Diagnostics

Wed, 25 Sep 2024 00:00:00 Z

Learn about how transitioning to glycerol-free reagents enhances molecular diagnostics by improving assay accuracy, efficiency, and global accessibility. Glycerol-free formulations enable lyophilization compatibility for stable, room-temperature storage and improve automation accuracy due to reduced viscosity, overcoming the challenges posed by glycerol in traditional reagent formulations.

Essential Tips for Successful DNA Gel Extraction

Thu, 05 Sep 2024 00:00:00 Z

Learn effective strategies to improve the purity and yield of DNA extracted from agarose gels, ensuring success in your downstream applications.

Genomes Without Borders: Bridging Gaps in Health Equity

Thu, 15 Aug 2024 00:00:00 Z

Claudia Gonzaga-Jauregui, Ph.D., discussed how underrepresentation undermines health equity when it comes to genomics in an NEB-hosted seminar and podcast episode. As of the time of writing, over 93% of genome-wide association studies had European ancestry, highlighting the lack of diversity. Focusing on her work, this blog breaks down some of the efforts to bridge the health equity gap in Mexico and Latin America as a whole.

Nancy Hopkins, Ph.D., Advocate for Women in STEM

Wed, 10 Jul 2024 00:00:00 Z

An interview with Nancy Hopkins, Ph.D., on the barriers and benefits to broadening the talent pool in life science.

Expert Tips & Tricks for Plasmid DNA Purification Using Miniprep Kits

Wed, 05 Jun 2024 00:00:00 Z

Are you struggling with low yields or impure samples from your plasmid minipreps? While plasmid DNA minipreps using kits may seem straightforward, issues can arise. In this blog post, we’ll share essential tips and tricks to help you navigate and overcome common hurdles in plasmid purification.

Optimizing mRNA Capping and Analysis

Mon, 13 May 2024 00:00:00 Z

Have you heard about the higher activity of our new capping enzyme and our improved approach for LC-MS RNA cap analysis?

Pioneering High-Altitude Reforestation with Reforest the Tropics and New England Biolabs^®

Sun, 21 Apr 2024 00:00:00 Z

Read our blog post on the latest collaboration between NEB^® and Reforest the Tropics in Costa Rica. This project is pushing the boundaries of reforestation, implementing innovative high-altitude strategies to enhance carbon sequestration and biodiversity. Join us in learning about this crucial step towards a sustainable future.

Navigating mRNA IVT

Mon, 25 Mar 2024 00:00:00 Z

Strategies for mRNA IVT templates, synthesis, capping and tailing, and purification that can streamline scale up or scale out for regulated markets.

E5hmC-seq™ is a Sequencing Method for Direct 5hmC Detection that Leverages Improved Data Quality from Enzymatic Conversion

Fri, 01 Mar 2024 00:00:00 Z

Learn about a new method to directly detect 5hmC at single-base resolution in this interview with NEB scientist, Dan Evanich, Ph.D..

Four alternative and powerful cloning applications of NEBuilder^® HiFi DNA assembly

Mon, 08 Jan 2024 00:00:00 Z

Explore the versatility of NEBuilder HiFi DNA Assembly in our latest blog. Expand your toolkit with four alternative applications for DNA manipulation.

The Vital Role of Restriction Enzymes in Molecular Cloning and DNA Assembly

Fri, 08 Dec 2023 00:00:00 Z

The functionality of restriction enzymes extends beyond bacterial defense mechanisms, with pivotal applications in genetic engineering processes.

Overcoming challenges in FFPE DNA library prep

Wed, 25 Oct 2023 00:00:00 Z

Formalin-fixed paraffin-embedded (FFPE) samples hold invaluable genetic insights, yet library preparation is notoriously challenging. FFPE preservation processes damage DNA, resulting in low yields, non-uniform ends, and other issues. Our advanced enzymatic solutions tackle these challenges, enabling the full utilization of FFPE samples for genetic analysis.

Superior error detection using Authenticase^® enhances assembled gene synthesis

Tue, 05 Sep 2023 00:00:00 Z

Gene synthesis often grapples with residual errors in DNA fragments, making traditional error detection methods labor-intensive and expensive. Authenticase^® employs structure-specific enzymes for proficient error correction. Paired with Q5® High-Fidelity DNA Polymerase, it enhances DNA quality and simplifies the synthesis workflow.

Sequencing Technologies and Bioinformatics: From data to workflow improvements

Fri, 04 Aug 2023 00:00:00 Z

Bioinformatics and computational biology relate to the analysis, interpretation and application of the data collected through biological research. In this blog post, we explore bioinformatics applications to genetic sequencing and the ways proximity between molecular biologists and bioinformatic scientists accelerates progress, amplifying research and product development impacts.

Mutate with Confidence! Tips and tools for successful site-directed mutagenesis experiments

Mon, 26 Jun 2023 00:00:00 Z

Site-directed mutagenesis methodologies have evolved from complex and time-consuming multi-day workflows to more efficient and streamlined protocols. In this blog post, we have compiled tips, tools and valuable insights from our scientists to maximize your efficiency and ensure your success.

Adding Capabilities to CRISPR-Cas-Based Biotechnology

Tue, 30 May 2023 00:00:00 Z

The Robb Lab at NEB collaborates with both academic and industry researchers in their mission of discovery, characterization, and application development efforts with CRISPR-Cas systems. It’s always galvanizing to look to the origin of CRISPR tools and consider how this scientific field has expanded into multiple substrate types and applications over time. While NEB produces many useful Cas nucleases to support research and development, the Robb Lab is always pursuing novel, distinctive properties – inspired by the abundance and diversity of Cas nucleases found in nature.

Genes in Space™ is a unique opportunity for young scientists to launch their ideas into orbit

Thu, 04 May 2023 00:00:00 Z

Learn how Pristine Onuoha's curiosity led to a space-ready assay that could detect differences in DNA fragment length, and the implications this has for bio-monitoring DNA changes in astronauts. Her experiment is set to launch to the International Space Station in June 2023.

Composting - an unsung hero in sustainability

Thu, 13 Apr 2023 00:00:00 Z

Many of us are aware of the challenges with plastic waste, and the crisis facing our oceans today. However, we don’t often think about organic waste and its environmental impacts. Luckily, the practice of composting can help manage organic waste and improve the sustainability of gardens and farms.

Nurturing artistic talent and reviving forgotten narratives: Indigo Arts Alliance's mission

Thu, 23 Mar 2023 00:00:00 Z

In our latest blog post, learn about how Indigo Arts Alliance have created a space that fosters connections between underrepresented Black and Brown artists, and how their collaborations embrace the shared history and experiences of the African diaspora.

Debunking the myths: clearing up six common misconceptions about reagent lyophilization

Fri, 03 Mar 2023 00:00:00 Z

Some misconceptions about lyophilization may prevent researchers from taking full advantage of its benefits. New England Biolabs Lyophilization Sciences™ Ltd. has extensive experience lyophilizing reagents for life science research and applied and diagnostics projects. In this blog post, you'll find answers to some of the most common questions our scientists are asked.

Support for educators provides an opportunity to teach hands-on molecular biology techniques

Thu, 08 Dec 2022 00:00:00 Z

The New England Biolabs^® DE&I Committee granted lab equipment to two passionate science teachers to enhance learning experiences in molecular biology.

What is the difference between intron-encoded and retroviral reverse transcriptases?

Wed, 16 Nov 2022 00:00:00 Z

Read about the difference between retroviral reverse transcriptases and group II intron-encoded reverse transcriptases and why one is a better choice for cDNA synthesis from long transcripts.

Getting started with loop-mediated isothermal amplification (LAMP)

Wed, 12 Oct 2022 00:00:00 Z

Are you thinking about using loop-mediated isothermal amplification (LAMP) but still have questions? In this blog post, we answer some of the most frequently asked questions we get about LAMP.

Four tips for PCR amplification of GC-rich sequences

Thu, 15 Sep 2022 00:00:00 Z

GC-rich DNA sequences can be difficult to amplify. In this blog post, we've outlined four key considerations from NEB scientists to troubleshoot your GC-rich PCR.

The right STEM program can open the door to a STEM career

Mon, 29 Aug 2022 00:00:00 Z

This blog will walk you through how to identify nearby programs that can introduce students to future careers in biology related fields.

Which DNA ligase is the best choice for DNA assembly?

Thu, 14 Jul 2022 00:00:00 Z

NEB researcher Katie Bilotti Ph.D. shares how deep characterization of end joining reactions reveals that ligase choice is vital for optimizing DNA assembly reactions, and more.

Monitoring tick and mosquito infections using LAMP: Screening for EEE and beyond

Wed, 22 Jun 2022 00:00:00 Z

The Carlow lab’s research and development of new field-friendly diagnostics for infectious disease is empowered by the loop-mediated isothermal amplification (LAMP) assay. A recent collaboration shows LAMP’s merits for monitoring mosquitoes for the EEE virus.

Guiding CRISPR/Cas13 Activity Using Chemically Modified Guides

Thu, 02 Jun 2022 00:00:00 Z

Dr. Neville Sanjana, a core faculty member at the New York Genome Center, explains his recent collaboration and publication detailing the use of chemically modified guide RNAs to enhance CRISPR-Cas13 knockdown in human cells.

Merging art & science – an alternative science career

Thu, 07 Apr 2022 00:00:00 Z

Tasha José, NEB's Scientific Illustrator, describes her exciting job role combining two of her passions - science & art.

Bringing the International Space Station into the Molecular Age

Thu, 10 Mar 2022 00:00:00 Z

With sights set on returning to the Moon and eventually Mars, NASA microbiologists create modified-for-spaceflight molecular workflows to diagnose potential medically significant pathogens in near real-time, entirely onboard the spacecraft.

Bisulfite sequencing, but at what cost?

Thu, 17 Feb 2022 00:00:00 Z

Why do so many core sequencing labs decline to perform bisulfite-seq? Let’s review the intrinsic risks of bisulfite conversion and then discuss how enzymatic cytosine conversion overcomes these challenges, enabling more biologically meaningful results at a lower cost with application versatility.

Bringing more COVID-19 testing to Africa

Thu, 27 Jan 2022 00:00:00 Z

With so few Africans vaccinated against COVID-19, simple and sensitive tests are critical for saving lives. NEB is donating reagents to aid in the development of diagnostic tests (cLAMP) that can be used instead of PCR and can deliver rapid results detected by a simple color change. They are ideally suited for resource-poor areas by not requiring expensive laboratory equipment.

Proven tips for PCR primer design

Mon, 08 Nov 2021 00:00:00 Z

PCR optimization and validation is a longtime passion at NEB. Avoid common PCR pitfalls and obtain the amplicon you desire with these primer design tips from our experts.

Using large-scale RNA sequencing to probe immune response, including autoimmune disease and vaccination

Wed, 13 Oct 2021 00:00:00 Z

Researchers are efficiently exploring immune responses with a new bulk RNA sequencing workflow that generates full-length reads of B or T cell receptor V(D)J and (C) region mRNA. The discoveries incorporating this unique view are shedding light on previously unanswerable questions surrounding immune response to infection and therapeutic intervention.

Bioinformatics alerts for viral variant impacts on molecular tests

Wed, 11 Aug 2021 00:00:00 Z

NEB bioinformatics scientist Brad Langhorst, Ph.D., discusses the impact of emerging variants on existing SARS-CoV-2 molecular tests, the key factor in test failures, who benefits from using NEB's new, Primer Monitor tool, and lessons from the pandemic for infectious disease outbreaks.

5 Tips to Stand out on LinkedIn with a Great Scientist Profile

Wed, 30 Jun 2021 00:00:00 Z

Life science recruiters and hiring managers frequently use LinkedIn to find job candidates. We spoke to a LinkedIn expert to explore how to make your LinkedIn profile help you find the perfect job in science.

RT-qPCR strategies for molecular diagnostics, OEM and customized solutions

Thu, 24 Jun 2021 00:00:00 Z

NEB Scientist Greg Patton, Ph.D., discusses how the molecular diagnostics field improves assay accuracy, robustness, and accessibility, for COVID RT-qPCR testing - including molecular technical advantages, OEM and customized reagent considerations to put upfront, and a tool to monitor for viral variant effects.

Supersizing Molecular Cloning by Rewriting the Rules for Golden Gate Assembly

Fri, 11 Jun 2021 00:00:00 Z

Read about how NEB scientists have rewritten the rules for Golden Gate Assembly of large multi-fragment targets - using Data-optimized Assembly Design (DAD) and modified protocols they have assembled the entire T7 bacteriophage genome from 52 fragments

Preventing COVID-19 Outbreaks through College Campus Surveillance Testing

Wed, 19 May 2021 00:00:00 Z

COVID-19 pooled testing is an efficient way to monitor viral spread within a community, and the loop mediated isothermal amplification (LAMP) assay is a major asset for community monitoring because it's inexpensive, fast, and accurate.

Bioremediation for sustainable clean water

Thu, 29 Apr 2021 00:00:00 Z

Read about how bioremediation has the potential to sustainably and economically address the global scarcity of potable water supplies, and how NEB puts bioremediation into practice to process campus wastewater.

Recycling styrofoam

Wed, 21 Apr 2021 00:00:00 Z

Learn what it takes to achieve the most eco-friendly disposal for EPS foam coolers and about some of the sustainable shipping solutions used by NEB to deliver molecular biology tools to scientists around the world.

Marine Biodiversity

Thu, 15 Apr 2021 00:00:00 Z

Have you ever wondered what proportion of all of the species on Earth live in the ocean? Learn about marine biodiversity, what threatens it, and the actions NEB takes to help protect it for future generations.

B Corp™ Certification Measures Environmental Sustainability and Much More

Thu, 08 Apr 2021 00:00:00 Z

Can a biotech be a B Corp™? Yes! Learn about eco-friendly actions taken by New England Biolabs that helped the company earn B Corp certification.

Using PaqCI^® for Golden Gate Assembly - What Makes it a Special Addition to the NEB Assembly Portfolio?

Wed, 07 Apr 2021 00:00:00 Z

Read about our new 7-base recognition sequence Type IIS restriction enzyme and how it can be used for simple to complex 24-fragment Golden Gate Assembly, achieving our highest level of efficiency and fidelity yet.

Ten ways to reduce laboratory waste

Thu, 01 Apr 2021 00:00:00 Z

The best way to reduce laboratory waste is with upstream thinking. Stop it before it starts. Here are ten actions that will help you to conserve life science lab resources and practice environmental stewardship, Earth Day and every day!

Think differently about your molecular diagnostics partners

Mon, 15 Mar 2021 00:00:00 Z

New England Biolabs^® (NEB^®) partners with customers globally to address the challenges faced by innovators developing the molecular diagnostics (MDx) technologies required to address public health and pandemic preparedness.

Dr. Peter Hotez champions low cost COVID-19 vaccines and training scientists for science communication

Mon, 01 Mar 2021 00:00:00 Z

NEB Passion in Science Award^® Winner and vaccine researcher Dr. Peter Hotez shares how low-cost vaccine biotechnology is being used to expand COVID-19 vaccine production globally, the urgency of opposing anti-science rhetoric, and insights from his new book Preventing the Next Pandemic: Vaccine Diplomacy in a Time of Anti-science.

High Molecular Weight (HMW) DNA Extraction – minimizing a bottleneck for emerging long read sequencing applications

Tue, 16 Feb 2021 00:00:00 Z

Extracting high quality, high molecular weight (HMW) DNA can be so time-consuming that it causes a bottleneck for the emerging, exciting downstream applications that require long DNA molecules as an input. Read about how scientists are addressing this bottleneck and how they are using the long read data to reveal a wealth of genomic information.

Harvesting improved methylome sequencing accuracy

Mon, 14 Dec 2020 00:00:00 Z

Plant epigenetics research is an attractive approach to enhance crops, rooted to accurate methylome analysis in a complex context. The performance of the Enzymatic Methyl-seq method merits replacing bisulfite conversion for high resolution plant methylation studies. Recently a team from the University of California Los Angeles took this leading-edge epigenomics method to task, comparing it to Whole Genome Bisulfite Sequencing (WGBS) results with Arabidopsis thaliana samples. Discover how researchers can improve studies of any eukaryotic methylome and you might become an EM-seq convert.

Research lab safety during COVID-19

Thu, 19 Nov 2020 00:00:00 Z

Adjusting to SARS-CoV-2 working conditions in research labs takes some getting used to. Find help tips and printable signage to remind lab members to practice COVID-19 safety guidelines in this blog post.

Bacterial art - incubating creativity in the lab

Wed, 21 Oct 2020 00:00:00 Z

Read about how science and art have become increasingly compartmentalized over time due to a focus on specialization. As a result, scientists communicate with scientists, and artists communicate with artists. Yet, there are parallels in the creative process and spirit behind both the scientific and artistic endeavors, and they are both studies and interpretations of the world around us. Using bacterial art, one lab at New England Biolabs encourages a mutualistic relationship between science and art, allowing the two cultures to inform and enrich each other.

SARS-CoV-2 RT-qPCR workflow research to advance clinical testing

Mon, 05 Oct 2020 00:00:00 Z

Creating streamlined workflows for COVID-19 testing remains a key step in solving the public health crisis. What sort of features will help make these tests more accessible and useful for clinicians? Let's consider that question with a look at the challenges set by the NIH RADx Initiative, the value of qPCR-based SARS-CoV-2 tests, new options from New England Biolabs for saliva samples and plug and play automation, and the recent call for a new testing paradigm.

Loop-mediated isothermal amplification allows testing to be performed anywhere

Tue, 08 Sep 2020 04:00:00 Z

Loop-mediated isothermal amplification (LAMP) is a fast-growing technology with a wide range of applications in human health and medical diagnosis. Because LAMP does not require the specialized equipment typically found in a molecular laboratory, it can simply and inexpensively be applied in a much broader range of settings. Read about how LAMP is used in COVID-19 research, vector-borne illness control programs, agriculture, and even on the International Space Station.

Reforestation Offers Benefits Over Carbon Credits

Tue, 08 Sep 2020 04:00:00 Z

Could reforestation efforts be the key to controlling climate change? Trees are able to sequester carbon efficiently, but they offer more than that. Trees also help control ground temperature, extend animal habitats and provide an income source to farmers. Reforestation offers broader reaching benefits than other carbon emission offset measures.

Large scale mRNA synthesis could be streamlined with thermostable RNA polymerase research advance

Tue, 08 Sep 2020 04:00:00 Z

Once a successful mRNA based vaccine is identified for COVID-19, the next hurdle for biopharma is producing a world supply of therapeutic mRNA. Production efficiency will be paramount for this undertaking! As RNA synthesis is evolving for use in medicine, RNA polymerase research is key to improving how RNA is made. Learn about an advance that could streamline conventional mRNA manufacturing workflows by safely circumventing the need for costly purification in this interview with NEB RNA Research Staff Scientist, Bijoyita Roy, Ph.D.

NEBinspired Blog

Cell-free DNA Synthesis for a Faster Path to RNA and DNA Therapeutics

8 tips to Follow When Choosing a Restriction Enzyme for In vitro mRNA Transcription for Vaccine and Therapeutics Production

A Universal PCR Annealing Temperature Means Balancing Convenience with Specificity

What to Do After Your Life Science Degree: Post-baccalaureate and Post-doctoral Programs

Building Genes Faster and Cheaper with Decentralized Workflows

Unlocking the Power of DNA Repair Enzymes in Molecular Biology Workflows

Advancing DNA Barcoding at the Royal Botanic Garden Edinburgh

Design, Assemble and Express with Confidence: Enabling High-throughput DNA Assembly and Protein Expression Workflows

mRNA Synthesis Democratized with Open-source Approach by BASE Facility Researchers

How Lyophilized Beads Are Changing Diagnostics and Research

Redefining NGS Library Prep for the Real World: Streamlining for Speed and Savings

Conserving Resources in Life Science

Engaging with Sustainability Through a Green Fair

OSA Conservation is Connecting Habitats to Create Climate Resilience for People and Nature in Costa Rica

Essential Tips for PCR & DNA Cleanup: Maximize Your DNA Purity and Yield

Beyond the NEB Catalog - Over 40 Years of Supporting Customers with Customized Solutions

Melding Scientific and Artistic Creativity

Imbuing Science with Compassion

Promoting More Sustainable Science

Shaping Scientific Access and Equality

Getting Started with Golden Gate Assembly

Afrigen's Mission to Empower Developing Countries with mRNA Vaccine Production

Choosing the Best Exonuclease for Your Workflow

Why Glycerol-free Reagents Matter in Molecular Diagnostics

Essential Tips for Successful DNA Gel Extraction

Genomes Without Borders: Bridging Gaps in Health Equity

Nancy Hopkins, Ph.D., Advocate for Women in STEM

Expert Tips & Tricks for Plasmid DNA Purification Using Miniprep Kits

Optimizing mRNA Capping and Analysis

Pioneering High-Altitude Reforestation with Reforest the Tropics and New England Biolabs®

Navigating mRNA IVT

E5hmC-seq™ is a Sequencing Method for Direct 5hmC Detection that Leverages Improved Data Quality from Enzymatic Conversion

Four alternative and powerful cloning applications of NEBuilder® HiFi DNA assembly

The Vital Role of Restriction Enzymes in Molecular Cloning and DNA Assembly

Overcoming challenges in FFPE DNA library prep

Superior error detection using Authenticase® enhances assembled gene synthesis

Sequencing Technologies and Bioinformatics: From data to workflow improvements

Mutate with Confidence! Tips and tools for successful site-directed mutagenesis experiments

Adding Capabilities to CRISPR-Cas-Based Biotechnology

Genes in Space™ is a unique opportunity for young scientists to launch their ideas into orbit

Composting - an unsung hero in sustainability

Nurturing artistic talent and reviving forgotten narratives: Indigo Arts Alliance's mission

Debunking the myths: clearing up six common misconceptions about reagent lyophilization

Support for educators provides an opportunity to teach hands-on molecular biology techniques

What is the difference between intron-encoded and retroviral reverse transcriptases?

Getting started with loop-mediated isothermal amplification (LAMP)

Four tips for PCR amplification of GC-rich sequences

The right STEM program can open the door to a STEM career

Which DNA ligase is the best choice for DNA assembly?

Monitoring tick and mosquito infections using LAMP: Screening for EEE and beyond

Guiding CRISPR/Cas13 Activity Using Chemically Modified Guides

Merging art & science – an alternative science career

Bringing the International Space Station into the Molecular Age

Bisulfite sequencing, but at what cost?

Bringing more COVID-19 testing to Africa

Proven tips for PCR primer design

Using large-scale RNA sequencing to probe immune response, including autoimmune disease and vaccination

Bioinformatics alerts for viral variant impacts on molecular tests

5 Tips to Stand out on LinkedIn with a Great Scientist Profile

RT-qPCR strategies for molecular diagnostics, OEM and customized solutions

Supersizing Molecular Cloning by Rewriting the Rules for Golden Gate Assembly

Preventing COVID-19 Outbreaks through College Campus Surveillance Testing

Bioremediation for sustainable clean water

Recycling styrofoam

Marine Biodiversity

B Corp™ Certification Measures Environmental Sustainability and Much More

Using PaqCI® for Golden Gate Assembly - What Makes it a Special Addition to the NEB Assembly Portfolio?

Ten ways to reduce laboratory waste

Think differently about your molecular diagnostics partners

Dr. Peter Hotez champions low cost COVID-19 vaccines and training scientists for science communication

High Molecular Weight (HMW) DNA Extraction – minimizing a bottleneck for emerging long read sequencing applications

Harvesting improved methylome sequencing accuracy

Research lab safety during COVID-19

Bacterial art - incubating creativity in the lab

SARS-CoV-2 RT-qPCR workflow research to advance clinical testing

Loop-mediated isothermal amplification allows testing to be performed anywhere

Reforestation Offers Benefits Over Carbon Credits

Large scale mRNA synthesis could be streamlined with thermostable RNA polymerase research advance

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Beyond the NEB Catalog -
Over 40 Years of Supporting Customers with Customized Solutions

Pioneering High-Altitude Reforestation with Reforest the Tropics and New England Biolabs^®

Four alternative and powerful cloning applications of NEBuilder^® HiFi DNA assembly

Superior error detection using Authenticase^® enhances assembled gene synthesis

Using PaqCI^® for Golden Gate Assembly - What Makes it a Special Addition to the NEB Assembly Portfolio?