FAQ: Which is the enzyme of choice to release α1-6 fucose residues from antibody glycans: α1-2,4,6 Fucosidase O or α1-2,3,4,6 Fucosidase from Bovine Kidney?

α1-2,4,6 Fucosidase O cleaves α1-6 fucose residues from antibody glycans more effectively than α1-2,3,4,6 Fucosidase from Bovine Kidney. α1-2,4,6 Fucosidase O does require an 18-hour incubation at 37°C for complete digestion.