FAQ: Has NEB used any enzymes in Chromatin Conformation Capture techniques, such as 3C or HiC? 

NEB has successfully used AluI, MseI, and HaeIII in formaldehyde fixed chromatin digestion, which can then be used in ChIP (Chromatin Immunoprecipitation) experiments. These enzymes have not been verified with 3C or HiC at this time.