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HomeFAQsCan I fluorescently label an O-glycan released by beta-elimination?
FAQ: Can I fluorescently label an O-glycan released by beta-elimination?
Beta-elimination (under alkaline conditions) will also result in degradation of the free carbohydrate from its reducing end (peeling). To prevent peeling, beta-elimination is typically performed under reductive conditions that convert the reducing sugar to its corresponding alditol. Sugar alditols are not substrates for fluorescent labeling by reductive amination.